PMID- 30672231
OWN - NLM
STAT- MEDLINE
DCOM- 20190506
LR  - 20190506
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 38
IP  - 10
DP  - 2018 Oct 12
TI  - [Impacts of the repetitive transcranial acupuncture stimulation on the content of 
      serum orexin A in patients with post-stroke insomnia].
PG  - 1039-42
LID - 10.13703/j.0255-2930.2018.10.003 [doi]
AB  - OBJECTIVE: To compare the effect on post-stroke insomnia between the repetitive 
      transcranial acupuncture stimulation (rTAS) and the conventional western 
      medication in the patients and to explore the mechanism. METHODS: Ninety patients 
      of post-stroke insomnia were randomized into a rTAS group, a medication group and 
      a placebo group, 30 cases in each one. In the rTAS group, patients were 
      intervened by rTAS. The acupoints were Baihui (GV 20), Ningshen (Extra), emotion 
      area, Wangu (GB 12), Taiyang (EX-HN 5), Neiguan (PC 6), Shenmen (HT 7), 
      Sanyinjiao (SP 6), Zhaohai (KI 6), Zusanli (ST 36) and Taichong (LR 3). Fast 
      twist with small amplitude was used at Baihui (GV 20) and emotion area for 2-3 
      min, 200-300 r/min, once 15 min. Electroacupuncture (EA) was applied at Baihui 
      (GV 20) and Ningshen (Extra), bilateral Wangu (GB 12), Sanyinjiao (SP 6) and 
      Zhaohai (KI 6) on the same side, 10 Hz, 0.5-1 mA. The treatment was given for 40 
      min in the rTAS group, once a day. Diazepam was prescribed orally in the 
      medication group before sleep, 2.5 mg a day. Starch capsule was used in the 
      placebo group before sleep, once a day. All the treatment was given for 
      continuous 1 month. The level of serum orexin A was observed before and after 
      treatment. The effects were compared. The recurrence rate was recorded 3 months 
      after treatment. RESULTS: The total effective rates in the rTAS group and the 
      medication group were 86.7% (26/30) and 90.0% (27/30) repectively after 
      treatment, which were better than 20.0% (6/30) in the placebo group (both 
      P<0.01). After treatment, the levels of serum orexin A in the rTAS group and the 
      medication group were lower than those before treatment (both P<0.01), which were 
      lower than that in the placebo group after treatment (both P<0.01), without 
      statistical significance between the rTAS group and the medication group after 
      treatment (P>0.05). The total effective rates in the rTAS group and the 
      medication group were 86.7% (26/30) and 86.7% (26/30) at follow-up repectively, 
      which were better than 16.7% (5/30) in the placebo group (both P<0.01). 
      CONCLUSION: The rTAS is safe and effective for post-stroke insomnia, which is 
      similar to oral medication of diazepam. The decreasing serum orexin A may be one 
      of the mechanisms.
FAU - Hou, Zhitao
AU  - Hou Z
AD  - Basic Medical School, Heilongjiang University of CM, Harbin 150040, China.
FAU - Sun, Zhongren
AU  - Sun Z
AD  - Basic Medical School, Heilongjiang University of CM, Harbin 150040, China.
FAU - Sun, Shentian
AU  - Sun S
AD  - Basic Medical School, Heilongjiang University of CM, Harbin 150040, China.
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
RN  - 0 (Orexins)
SB  - IM
MH  - *Acupuncture Therapy
MH  - Humans
MH  - Orexins
MH  - *Sleep Initiation and Maintenance Disorders/therapy
MH  - *Stroke
OTO - NOTNLM
OT  - orexin A
OT  - post-stroke insomnia
OT  - randomized controlled trial (RCT)
OT  - repetitive transcranial acupuncture stimulation
EDAT- 2019/01/24 06:00
MHDA- 2019/05/07 06:00
CRDT- 2019/01/24 06:00
PHST- 2019/01/24 06:00 [entrez]
PHST- 2019/01/24 06:00 [pubmed]
PHST- 2019/05/07 06:00 [medline]
AID - 10.13703/j.0255-2930.2018.10.003 [doi]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2018 Oct 12;38(10):1039-42. doi: 
      10.13703/j.0255-2930.2018.10.003.