PMID- 30672439
OWN - NLM
STAT- MEDLINE
DCOM- 20190517
LR  - 20190517
IS  - 1165-158X (Electronic)
IS  - 0145-5680 (Linking)
VI  - 64
IP  - 15
DP  - 2018 Dec 31
TI  - Effects of Leontice leontopetalum and Bongardia chrysogonum on oxidative stress 
      and neuroprotection in PTZ kindling epilepsy in rats.
PG  - 71-77
AB  - We investigated the effects of Leontice leontopetalum and Bongardia chrysogonum 
      on apoptosis, gamma-aminobutyric acid (GABAA) receptor positive cell number, 
      cyclin-B1 and bcl-2 levels and oxidative stress in pentylenetetrazol (PTZ) 
      kindling in rats. Kindling was produced by subconvulsant doses of PTZ treatments 
      in rats. Wistar albino rats were divided into 4 groups; Control, PTZ treated 
      (PTZ), PTZ+L. leontopetalum extract treated (PTZ+LLE) and PTZ+B. chrysogonum 
      extract treated (PTZ+BCE) groups. Extracts were given a dose (200 mg/kg) 2h 
      before each PTZ injection. PTZ treatment significantly decreased the glutathione 
      peroxidase (GSH-Px), superoxide dismutase (SOD) activities and bcl-2 levels and 
      increased the total oxidant status (TOS), malondialdehyde (MDA), cyclin B1, 
      oxidative stress index (OSI) and number of neurons that expressed GABAA receptors 
      when compared to the control. LLE and BCE possessed antioxidant activity in the 
      brain and ameliorated PTZ induced oxidative stress, decreased cyclin-B1, 
      increased bcl-2 levels, and kept the GABAA receptor number similar to that of the 
      control despite the PTZ application.
FAU - Ergul Erkec, Ozlem
AU  - Ergul Erkec O
AD  - Department of Physiology, Faculty of Medicine, Van Yuzuncu Yil University, Van, 
      Turkey.
FAU - Arihan, Okan
AU  - Arihan O
AD  - Department of Physiology, Faculty of Medicine, Van Yuzuncu Yil University, Van, 
      Turkey.
FAU - Kara, Mehmet
AU  - Kara M
AD  - Department of Physiology, Faculty of Medicine, Van Yuzuncu Yil University, Van, 
      Turkey.
FAU - Karatas, Ersin
AU  - Karatas E
AD  - Department of Medical Biochemistry, Faculty of Medicine, Bezmialem Vakif 
      University, Istanbul, Turkey.
FAU - Erten, Remzi
AU  - Erten R
AD  - Department of Pathology, Faculty of Medicine, Van Yuzuncu Yil University, Van, 
      Turkey.
FAU - Demir, Halit
AU  - Demir H
AD  - Department of Chemistry, Faculty of Science, Van Yuzuncu Yil University, Van, 
      Turkey.
FAU - Meral, Ismail
AU  - Meral I
AD  - Department of Physiology, Faculty of Medicine, Bezmialem Vakif University, 
      Istanbul, Turkey.
FAU - Mukemre, Muzaffer
AU  - Mukemre M
AD  - Department of Biology, Faculty of Science, Van Yuzuncu Yil University, Van, 
      Turkey.
FAU - Ozgokce, Fevzi
AU  - Ozgokce F
AD  - Department of Biology, Faculty of Science, Van Yuzuncu Yil University, Van, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20181231
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Cyclin B1)
RN  - 0 (Plant Extracts)
RN  - 0 (Receptors, GABA)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - WM5Z385K7T (Pentylenetetrazole)
SB  - IM
MH  - Animals
MH  - Berberidaceae/*chemistry
MH  - Cyclin B1/metabolism
MH  - Epilepsy/*chemically induced/drug therapy/*pathology
MH  - Glutathione Peroxidase/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Kindling, Neurologic/*drug effects
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Neuroprotection/*drug effects
MH  - Oxidative Stress/*drug effects
MH  - Pentylenetetrazole
MH  - Plant Extracts/*pharmacology/therapeutic use
MH  - Rats, Wistar
MH  - Receptors, GABA/metabolism
MH  - Superoxide Dismutase/metabolism
OTO - NOTNLM
OT  - Bcl-2
OT  - Bongardia chrysogonum
OT  - Brain
OT  - Cyclin-B1
OT  - GABAA
OT  - Leontice leontopetalum
OT  - Oxidative stress
OT  - Pentylenetetrazol.
OT  - kindling model
EDAT- 2019/01/24 06:00
MHDA- 2019/05/18 06:00
CRDT- 2019/01/24 06:00
PHST- 2018/05/07 00:00 [received]
PHST- 2018/12/17 00:00 [accepted]
PHST- 2018/12/14 00:00 [revised]
PHST- 2019/01/24 06:00 [entrez]
PHST- 2019/01/24 06:00 [pubmed]
PHST- 2019/05/18 06:00 [medline]
PST - epublish
SO  - Cell Mol Biol (Noisy-le-grand). 2018 Dec 31;64(15):71-77.