PMID- 30674009
OWN - NLM
STAT- MEDLINE
DCOM- 20191227
LR  - 20200225
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 42
IP  - 8
DP  - 2019 Aug
TI  - Epicardial adipose tissue is a predictor of decreased kidney function and 
      coronary artery calcification in youth- and early adult onset type 2 diabetes 
      mellitus.
PG  - 979-986
LID - 10.1007/s40618-019-1011-8 [doi]
AB  - PURPOSE: To examine the association of epicardial and pericardial fat volume 
      (EFV, PFV) with cardiovascular risk factors and kidney function in Native 
      Americans of southwestern heritage with youth and early adult onset type 2 
      diabetes mellitus (T2DM) versus healthy controls. METHODS: Using computed 
      tomography, we quantified EFV and PFV in 149 Native Americans (92 women, 57 men), 
      95 of which had T2DM (38 diagnosed prior to age 20 years). Duration of T2DM, mean 
      carotid arterial mass (AM), coronary artery calcification (CAC), IL-6, and 
      estimated glomerular filtration rate eGFR(cr(CKD-EPI)) were measured. RESULTS: 
      EFV and PFV were associated with BMI (r = 0.37, p < 0.0001; r = 0.26, p = 0.001) 
      and did not differ between onset age-groups and controls (p > 0.05). EFV was 
      associated with AM only in controls (r = 0.51, p < 0.0001). After adjustment for 
      BMI, T2DM duration, HbA1C, age, and sex, EFV was a predictor of CAC and IL-6 
      concentrations in early adult onset T2DM (beta = 0.05 +/- 0.02 cm(3), p = 0.03; 
      beta = 0.05 +/- 0.01 pg/ml/cm(3), p = 0.002). EFV and PFV were independent predictors 
      of reduced eGFR(cr(CKD-EPI)) in the youth onset T2DM group 
      (beta = -0.3 +/- 0.08 ml/min/cm(3), p = 0.001; beta = -0.25 +/- 0.05 ml/min/cm(3), 
      p < 0.0001). CONCLUSIONS: Epicardial fat volume may be a risk factor for heart 
      disease in individuals with early adult onset T2DM and a predictor of decreased 
      kidney function in individuals with youth onset T2DM.
FAU - Reinhardt, M
AU  - Reinhardt M
AD  - Obesity and Diabetes Clinical Research Section, Department of Health and Human 
      Services, Phoenix Epidemiology and Clinical Research Branch National Institute of 
      Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 
      4212 N. 16th Street, Phoenix, AZ, 85016, USA. 
      martin.reinhardt@medizin.uni-leipzig.de.
AD  - Department of Diagnostic and Interventional Radiology, University of Leipzig 
      Medical Center, Liebigstrasse 20, 04103, Leipzig, Germany. 
      martin.reinhardt@medizin.uni-leipzig.de.
FAU - Cushman, T R
AU  - Cushman TR
AD  - Obesity and Diabetes Clinical Research Section, Department of Health and Human 
      Services, Phoenix Epidemiology and Clinical Research Branch National Institute of 
      Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 
      4212 N. 16th Street, Phoenix, AZ, 85016, USA.
FAU - Thearle, M S
AU  - Thearle MS
AD  - Obesity and Diabetes Clinical Research Section, Department of Health and Human 
      Services, Phoenix Epidemiology and Clinical Research Branch National Institute of 
      Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 
      4212 N. 16th Street, Phoenix, AZ, 85016, USA.
FAU - Krakoff, J
AU  - Krakoff J
AD  - Obesity and Diabetes Clinical Research Section, Department of Health and Human 
      Services, Phoenix Epidemiology and Clinical Research Branch National Institute of 
      Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 
      4212 N. 16th Street, Phoenix, AZ, 85016, USA.
LA  - eng
PT  - Journal Article
DEP - 20190123
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adipose Tissue/*pathology
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Biomarkers/*analysis
MH  - Case-Control Studies
MH  - Child
MH  - Coronary Artery Disease/*diagnosis/etiology
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Epicardial Mapping
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Pericardium/*pathology
MH  - Prognosis
MH  - Renal Insufficiency/*diagnosis/etiology
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Coronary calcification
OT  - Epicardial adipose tissue
OT  - Kidney function
OT  - Pericardial adipose tissue
OT  - Type 2 diabetes mellitus
EDAT- 2019/01/24 06:00
MHDA- 2019/12/28 06:00
CRDT- 2019/01/24 06:00
PHST- 2018/08/20 00:00 [received]
PHST- 2019/01/16 00:00 [accepted]
PHST- 2019/01/24 06:00 [pubmed]
PHST- 2019/12/28 06:00 [medline]
PHST- 2019/01/24 06:00 [entrez]
AID - 10.1007/s40618-019-1011-8 [pii]
AID - 10.1007/s40618-019-1011-8 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2019 Aug;42(8):979-986. doi: 10.1007/s40618-019-1011-8. Epub 
      2019 Jan 23.