PMID- 30674592 OWN - NLM STAT- MEDLINE DCOM- 20191125 LR - 20210325 IS - 1526-632X (Electronic) IS - 0028-3878 (Print) IS - 0028-3878 (Linking) VI - 92 IP - 8 DP - 2019 Feb 19 TI - Type 2 diabetes mellitus, brain atrophy, and cognitive decline. PG - e823-e830 LID - 10.1212/WNL.0000000000006955 [doi] AB - OBJECTIVE: To study longitudinal relationships between type 2 diabetes mellitus (T2DM), cortical thickness, and cognitive function in older people with normal cognition, mild cognitive impairment, and Alzheimer disease (AD). METHODS: The sample was derived from the Alzheimer's Disease Neuroimaging Initiative cohort who underwent brain MRI and cognitive tests annually for 5 years. Presence of T2DM was based on fasting blood glucose >/=7.0mml/L or the use of glucose-lowering agents. We used latent growth curve modeling to explore longitudinal relationships between T2DM, cortical thickness, and cognitive function, adjusting for relevant covariates and testing for interactions. RESULTS: There were 124 people with T2DM (mean age 75.5 years, SD 6.2) and 693 without T2DM (mean age 75.1 years, SD 6.9) with at least 1 MRI available. AD and lower cortical thickness at study entry was associated with a lower chance of having a MRI available at each follow-up phase (all p < 0.001). T2DM was associated with lower baseline cortical thickness (p = 0.01). We found no direct effect of T2DM on decline in cortical thickness or cognitive function, but there was an indirect pathway linking T2DM and cognitive decline via baseline cortical thickness (beta = -0.17, p = 0.022). There was an interaction between T2DM and education whereby the negative effect of T2DM on baseline cortical thickness was reduced in those with greater education (beta = 0.34, p = 0.037). These associations changed minimally when adjusted for baseline cognitive diagnosis. CONCLUSIONS: In an older cohort with low cerebrovascular disease burden, T2DM contributes to cognitive decline via neurodegeneration. Prior brain and cognitive reserve may protect against this effect. CI - (c) 2019 American Academy of Neurology. FAU - Moran, Chris AU - Moran C AD - From the Department of Medicine (C.M., R.B., W.W., M.C., V.S.), Peninsula Clinical School, Central Clinical School, Monash University; Departments of Medicine and Geriatric Medicine (C.M., V.S.), Peninsula Health; Department of Aged Care (C.M.), Caulfield Hospital, Alfred Health; Developmental Imaging (R.B.), Murdoch Children's Research Institute, Melbourne; and Menzies Institute for Medical Research (M.C., V.S.), University of Tasmania, Hobart, Australia. chris.moran@monash.edu. FAU - Beare, Richard AU - Beare R AD - From the Department of Medicine (C.M., R.B., W.W., M.C., V.S.), Peninsula Clinical School, Central Clinical School, Monash University; Departments of Medicine and Geriatric Medicine (C.M., V.S.), Peninsula Health; Department of Aged Care (C.M.), Caulfield Hospital, Alfred Health; Developmental Imaging (R.B.), Murdoch Children's Research Institute, Melbourne; and Menzies Institute for Medical Research (M.C., V.S.), University of Tasmania, Hobart, Australia. FAU - Wang, Wei AU - Wang W AD - From the Department of Medicine (C.M., R.B., W.W., M.C., V.S.), Peninsula Clinical School, Central Clinical School, Monash University; Departments of Medicine and Geriatric Medicine (C.M., V.S.), Peninsula Health; Department of Aged Care (C.M.), Caulfield Hospital, Alfred Health; Developmental Imaging (R.B.), Murdoch Children's Research Institute, Melbourne; and Menzies Institute for Medical Research (M.C., V.S.), University of Tasmania, Hobart, Australia. FAU - Callisaya, Michele AU - Callisaya M AD - From the Department of Medicine (C.M., R.B., W.W., M.C., V.S.), Peninsula Clinical School, Central Clinical School, Monash University; Departments of Medicine and Geriatric Medicine (C.M., V.S.), Peninsula Health; Department of Aged Care (C.M.), Caulfield Hospital, Alfred Health; Developmental Imaging (R.B.), Murdoch Children's Research Institute, Melbourne; and Menzies Institute for Medical Research (M.C., V.S.), University of Tasmania, Hobart, Australia. FAU - Srikanth, Velandai AU - Srikanth V AD - From the Department of Medicine (C.M., R.B., W.W., M.C., V.S.), Peninsula Clinical School, Central Clinical School, Monash University; Departments of Medicine and Geriatric Medicine (C.M., V.S.), Peninsula Health; Department of Aged Care (C.M.), Caulfield Hospital, Alfred Health; Developmental Imaging (R.B.), Murdoch Children's Research Institute, Melbourne; and Menzies Institute for Medical Research (M.C., V.S.), University of Tasmania, Hobart, Australia. CN - Alzheimer's Disease Neuroimaging Initiative (ADNI) LA - eng GR - P30 AG010133/AG/NIA NIH HHS/United States GR - R01 AG019771/AG/NIA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20190123 PL - United States TA - Neurology JT - Neurology JID - 0401060 RN - 0 (Blood Glucose) SB - IM CIN - Neurology. 2020 Jan 7;94(1):48-49. PMID: 31889017 CIN - Neurology. 2020 Jan 7;94(1):49. PMID: 31889018 MH - Aged MH - Aged, 80 and over MH - Alzheimer Disease/diagnostic imaging/*epidemiology MH - Atrophy/epidemiology MH - Blood Glucose/metabolism MH - Brain/*diagnostic imaging/pathology MH - Cerebral Cortex/diagnostic imaging/pathology MH - Cognitive Dysfunction/diagnostic imaging/*epidemiology MH - Diabetes Mellitus, Type 2/*epidemiology/metabolism MH - Factor Analysis, Statistical MH - Female MH - Humans MH - Longitudinal Studies MH - Magnetic Resonance Imaging MH - Male MH - Organ Size PMC - PMC7987953 FIR - Weiner, Michael IR - Weiner M FIR - Aisen, Paul IR - Aisen P FIR - Weiner, Michael IR - Weiner M FIR - Aisen, Paul IR - Aisen P FIR - Petersen, Ronald IR - Petersen R FIR - Jack, Clifford R Jr IR - Jack CR Jr FIR - Jagust, William IR - Jagust W FIR - Trojanowki, John Q IR - Trojanowki JQ FIR - Toga, Arthur W IR - Toga AW FIR - Beckett, Laurel IR - Beckett L FIR - Green, Robert C IR - Green RC FIR - Saykin, Andrew J IR - Saykin AJ FIR - Morris, John IR - Morris J FIR - Liu, Enchi IR - Liu E FIR - Green, Robert C IR - Green RC FIR - Montine, Tom IR - Montine T FIR - Petersen, Ronald IR - Petersen R FIR - Aisen, Paul IR - Aisen P FIR - Gamst, Anthony IR - Gamst A FIR - Thomas, Ronald G IR - Thomas RG FIR - Donohue, Michael IR - Donohue M FIR - Walter, Sarah IR - Walter S FIR - Gessert, Devon IR - Gessert D FIR - Sather, Tamie IR - Sather T FIR - Beckett, Laurel IR - Beckett L FIR - Harvey, Danielle IR - Harvey D FIR - Gamst, Anthony IR - Gamst A FIR - Donohue, Michael IR - Donohue M FIR - Kornak, John IR - Kornak J FIR - Jack, Clifford R Jr IR - Jack CR Jr FIR - Dale, Anders IR - Dale A FIR - Bernstein, Matthew IR - Bernstein M FIR - Felmlee, Joel IR - Felmlee J FIR - Fox, Nick IR - Fox N FIR - Thompson, Paul IR - Thompson P FIR - Schuff, Norbert IR - Schuff N FIR - Alexander, Gene IR - Alexander G FIR - DeCarli, Charles IR - DeCarli C FIR - Jagust, William IR - Jagust W FIR - Bandy, Dan IR - Bandy D FIR - Koeppe, Robert A IR - Koeppe RA FIR - Foster, Norm IR - Foster N FIR - Reiman, Eric M IR - Reiman EM FIR - Chen, Kewei IR - Chen K FIR - Mathis, Chet IR - Mathis C FIR - Morris, John IR - Morris J FIR - Cairns, Nigel J IR - Cairns NJ FIR - Taylor-Reinwald, Lisa IR - Taylor-Reinwald L FIR - Trojanowki, J Q IR - Trojanowki JQ FIR - Shaw, Les IR - Shaw L FIR - Lee, Virginia M Y IR - Lee VMY FIR - Korecka, Magdalena IR - Korecka M FIR - Toga, Arthur W IR - Toga AW FIR - Crawford, Karen IR - Crawford K FIR - Neu, Scott IR - Neu S FIR - Saykin, Andrew J IR - Saykin AJ FIR - Foroud, Tatiana M IR - Foroud TM FIR - Potkin, Steven IR - Potkin S FIR - Shen, Li IR - Shen L FIR - Kachaturian, Zaven IR - Kachaturian Z FIR - Frank, Richard IR - Frank R FIR - Snyder, Peter J IR - Snyder PJ FIR - Molchan, Susan IR - Molchan S FIR - Kaye, Jeffrey IR - Kaye J FIR - Quinn, Joseph IR - Quinn J FIR - Lind, Betty IR - Lind B FIR - Dolen, Sara IR - Dolen S FIR - Schneider, Lon S IR - Schneider LS FIR - Pawluczyk, Sonia IR - Pawluczyk S FIR - Spann, Bryan M IR - Spann BM FIR - Brewer, James IR - Brewer J FIR - Vanderswag, Helen IR - Vanderswag H FIR - Heidebrink, Judith L IR - Heidebrink JL FIR - Lord, Joanne L IR - Lord JL FIR - Petersen, Ronald IR - Petersen R FIR - Johnson, Kris IR - Johnson K FIR - Doody, Rachelle S IR - Doody RS FIR - Villanueva-Meyer, Javier IR - Villanueva-Meyer J FIR - Chowdhury, Munir IR - Chowdhury M FIR - Stern, Yaakov IR - Stern Y FIR - Honig, Lawrence S IR - Honig LS FIR - Bell, Karen L IR - Bell KL FIR - Morris, John C IR - Morris JC FIR - Ances, Beau IR - Ances B FIR - Carroll, Maria IR - Carroll M FIR - Leon, Sue IR - Leon S FIR - Mintun, Mark A IR - Mintun MA FIR - Schneider, Stacy IR - Schneider S FIR - Marson, Daniel IR - Marson D FIR - Griffith, Randall IR - Griffith R FIR - Clark, David IR - Clark D FIR - Grossman, Hillel IR - Grossman H FIR - Mitsis, Effie IR - Mitsis E FIR - Romirowsky, Aliza IR - Romirowsky A FIR - deToledo-Morrell, Leyla IR - deToledo-Morrell L FIR - Shah, Raj C IR - Shah RC FIR - Duara, Ranjan IR - Duara R FIR - Varon, Daniel IR - Varon D FIR - Roberts, Peggy IR - Roberts P FIR - Albert, Marilyn IR - Albert M FIR - Onyike, Chiadi IR - Onyike C FIR - Kielb, Stephanie IR - Kielb S FIR - Rusinek, Henry IR - Rusinek H FIR - de Leon, Mony J IR - de Leon MJ FIR - Glodzik, Lidia IR - Glodzik L FIR - De Santi, Susan IR - De Santi S FIR - Doraiswamy, P Murali IR - Doraiswamy PM FIR - Petrella, Jeffrey R IR - Petrella JR FIR - Coleman, R Edward IR - Coleman RE FIR - Arnold, Steven E IR - Arnold SE FIR - Karlawish, Jason H IR - Karlawish JH FIR - Wolk, David IR - Wolk D FIR - Smith, Charles D IR - Smith CD FIR - Jicha, Greg IR - Jicha G FIR - Hardy, Peter IR - Hardy P FIR - Lopez, Oscar L IR - Lopez OL FIR - Oakley, MaryAnn IR - Oakley M FIR - Simpson, Donna M IR - Simpson DM FIR - Porsteinsson, Anton P IR - Porsteinsson AP FIR - Goldstein, Bonnie S IR - Goldstein BS FIR - Martin, Kim IR - Martin K FIR - Makino, Kelly M IR - Makino KM FIR - Ismail, M Saleem IR - Ismail MS FIR - Brand, Connie IR - Brand C FIR - Mulnard, Ruth A IR - Mulnard RA FIR - Thai, Gaby IR - Thai G FIR - McAdams-Ortiz, Catherine IR - McAdams-Ortiz C FIR - Womack, Kyle IR - Womack K FIR - Mathews, Dana IR - Mathews D FIR - Quiceno, Mary IR - Quiceno M FIR - Diaz-Arrastia, Ramon IR - Diaz-Arrastia R FIR - King, Richard IR - King R FIR - Weiner, Myron IR - Weiner M FIR - Martin-Cook, Kristen IR - Martin-Cook K FIR - DeVous, Michael IR - DeVous M FIR - Levey, Allan I IR - Levey AI FIR - Lah, James J IR - Lah JJ FIR - Cellar, Janet S IR - Cellar JS FIR - Burns, Jeffrey M IR - Burns JM FIR - Anderson, Heather S IR - Anderson HS FIR - Swerdlow, Russell H IR - Swerdlow RH FIR - Apostolova, Liana IR - Apostolova L FIR - Lu, Po H IR - Lu PH FIR - Bartzokis, George IR - Bartzokis G FIR - Silverman, Daniel H S IR - Silverman DHS FIR - Graff-Radford, Neill R IR - Graff-Radford NR FIR - Parfitt, Francine IR - Parfitt F FIR - Johnson, Heather IR - Johnson H FIR - Farlow, Martin R IR - Farlow MR FIR - Hake, Ann Marie IR - Hake AM FIR - Matthews, Brandy R IR - Matthews BR FIR - Herring, Scott IR - Herring S FIR - van Dyck, Christopher H IR - van Dyck CH FIR - Carson, Richard E IR - Carson RE FIR - MacAvoy, Martha G IR - MacAvoy MG FIR - Chertkow, Howard IR - Chertkow H FIR - Bergman, Howard IR - Bergman H FIR - Hosein, Chris IR - Hosein C FIR - Black, Sandra IR - Black S FIR - Stefanovic, Bojana IR - Stefanovic B FIR - Caldwell, Curtis IR - Caldwell C FIR - Robin Hsiung, Ging-Yuek IR - Robin Hsiung GY FIR - Feldman, Howard IR - Feldman H FIR - Mudge, Benita IR - Mudge B FIR - Assaly, Michele IR - Assaly M FIR - Kertesz, Andrew IR - Kertesz A FIR - Rogers, John IR - Rogers J FIR - Trost, Dick IR - Trost D FIR - Bernick, Charles IR - Bernick C FIR - Munic, Donna IR - Munic D FIR - Kerwin, Diana IR - Kerwin D FIR - Mesulam, Marek-Marsel IR - Mesulam MM FIR - Lipowski, Kristina IR - Lipowski K FIR - Wu, Chuang-Kuo IR - Wu CK FIR - Johnson, Nancy IR - Johnson N FIR - Sadowsky, Carl IR - Sadowsky C FIR - Martinez, Walter IR - Martinez W FIR - Villena, Teresa IR - Villena T FIR - Turner, Raymond Scott IR - Turner RS FIR - Johnson, Kathleen IR - Johnson K FIR - Reynolds, Brigid IR - Reynolds B FIR - Sperling, Reisa A IR - Sperling RA FIR - Johnson, Keith A IR - Johnson KA FIR - Marshall, Gad IR - Marshall G FIR - Frey, Meghan IR - Frey M FIR - Yesavage, Jerome IR - Yesavage J FIR - Taylor, Joy L IR - Taylor JL FIR - Lane, Barton IR - Lane B FIR - Rosen, Allyson IR - Rosen A FIR - Tinklenberg, Jared IR - Tinklenberg J FIR - Sabbagh, Marwan IR - Sabbagh M FIR - Belden, Christine IR - Belden C FIR - Jacobson, Sandra IR - Jacobson S FIR - Kowall, Neil IR - Kowall N FIR - Killiany, Ronald IR - Killiany R FIR - Budson, Andrew E IR - Budson AE FIR - Norbash, Alexander IR - Norbash A FIR - Johnson, Patricia Lynn IR - Johnson PL FIR - Obisesan, Thomas O IR - Obisesan TO FIR - Wolday, Saba IR - Wolday S FIR - Bwayo, Salome K IR - Bwayo SK FIR - Lerner, Alan IR - Lerner A FIR - Hudson, Leon IR - Hudson L FIR - Ogrocki, Paula IR - Ogrocki P FIR - Fletcher, Evan IR - Fletcher E FIR - Carmichael, Owen IR - Carmichael O FIR - Olichney, John IR - Olichney J FIR - DeCarli, Charles IR - DeCarli C FIR - Kittur, Smita IR - Kittur S FIR - Borrie, Michael IR - Borrie M FIR - Lee, T-Y IR - Lee TY FIR - Bartha, Dr Rob IR - Bartha DR FIR - Johnson, Sterling IR - Johnson S FIR - Asthana, Sanjay IR - Asthana S FIR - Carlsson, Cynthia M IR - Carlsson CM FIR - Potkin, Steven G IR - Potkin SG FIR - Preda, Adrian IR - Preda A FIR - Nguyen, Dana IR - Nguyen D FIR - Tariot, Pierre IR - Tariot P FIR - Fleisher, Adam IR - Fleisher A FIR - Reeder, Stephanie IR - Reeder S FIR - Bates, Vernice IR - Bates V FIR - Capote, Horacio IR - Capote H FIR - Rainka, Michelle IR - Rainka M FIR - Scharre, Douglas W IR - Scharre DW FIR - Kataki, Maria IR - Kataki M FIR - Zimmerman, Earl A IR - Zimmerman EA FIR - Celmins, Dzintra IR - Celmins D FIR - Brown, Alice D IR - Brown AD FIR - Pearlson, Godfrey D IR - Pearlson GD FIR - Blank, Karen IR - Blank K FIR - Anderson, Karen IR - Anderson K FIR - Saykin, Andrew J IR - Saykin AJ FIR - Santulli, Robert B IR - Santulli RB FIR - Schwartz, Eben S IR - Schwartz ES FIR - Sink, Kaycee M IR - Sink KM FIR - Williamson, Jeff D IR - Williamson JD FIR - Garg, Pradeep IR - Garg P FIR - Watkins, Franklin IR - Watkins F FIR - Ott, Brian R IR - Ott BR FIR - Querfurth, Henry IR - Querfurth H FIR - Tremont, Geoffrey IR - Tremont G FIR - Salloway, Stephen IR - Salloway S FIR - Malloy, Paul IR - Malloy P FIR - Correia, Stephen IR - Correia S FIR - Rosen, Howard J IR - Rosen HJ FIR - Miller, Bruce L IR - Miller BL FIR - Mintzer, Jacobo IR - Mintzer J FIR - Longmire, Crystal Flynn IR - Longmire CF FIR - Spicer, Kenneth IR - Spicer K FIR - Finger, Elizabether IR - Finger E FIR - Rachinsky, Irina IR - Rachinsky I FIR - Rogers, John IR - Rogers J FIR - Kertesz, Andrew IR - Kertesz A FIR - Drost, Dick IR - Drost D FIR - Pomara, Nunzio IR - Pomara N FIR - Hernando, Raymundo IR - Hernando R FIR - Sarrael, Antero IR - Sarrael A FIR - Schultz, Susan K IR - Schultz SK FIR - Boles Ponto, Laura L IR - Boles Ponto LL FIR - Shim, Hyungsub IR - Shim H FIR - Smith, Karen Elizabeth IR - Smith KE FIR - Relkin, Norman IR - Relkin N FIR - Chaing, Gloria IR - Chaing G FIR - Raudin, Lisa IR - Raudin L FIR - Smith, Amanda IR - Smith A FIR - Fargher, Kristin IR - Fargher K FIR - Raj, Balebail Ashok IR - Raj BA EDAT- 2019/01/25 06:00 MHDA- 2019/11/26 06:00 PMCR- 2019/02/19 CRDT- 2019/01/25 06:00 PHST- 2018/04/30 00:00 [received] PHST- 2018/10/13 00:00 [accepted] PHST- 2019/01/25 06:00 [pubmed] PHST- 2019/11/26 06:00 [medline] PHST- 2019/01/25 06:00 [entrez] PHST- 2019/02/19 00:00 [pmc-release] AID - WNL.0000000000006955 [pii] AID - NEUROLOGY2018902635 [pii] AID - 10.1212/WNL.0000000000006955 [doi] PST - ppublish SO - Neurology. 2019 Feb 19;92(8):e823-e830. doi: 10.1212/WNL.0000000000006955. Epub 2019 Jan 23.