PMID- 30675213
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 17
IP  - 2
DP  - 2019 Feb
TI  - Expression of p53 in ground-glass nodule of lung cancer and non-lung cancer 
      patients.
PG  - 1559-1564
LID - 10.3892/ol.2018.9797 [doi]
AB  - The present study investigated the expression of p53 in ground-glass nodule (GGN) 
      of lung cancer and non-lung cancer patients, and explored the correlation with 
      prognosis. A total of 120 GGN patients admitted to the Department of Respiratory 
      Medicine in the Second Affiliated Hospital of Zhejiang University School of 
      Medicine during the period from March 2010 to March 2014 were selected. These 
      patients included 60 lung cancer patients and 60 non-tumor patients. Biopsy or 
      surgical specimens were collected. Fluorescence in situ hybridization (FISH) and 
      immunohistochemistry (IHC) were used to detect p53 gene and protein expression in 
      the two groups of GGN tissues. All patients were followed up for 3 years and the 
      relationship between p53 protein expression and the overall survival (OS) of the 
      two groups of patients was analyzed. In GGN cells of non-cancer patients, p53 
      absence was observed in 6 cases and the absence rate was 10.0%. In GGN cells of 
      cancer patients, the absence rate was significantly higher than that of 
      non-cancer GGN group (p<0.05). The positive rate of p53-positive cases in 
      non-tumor patients GGN group was lower than that of in GGN tissues of lung cancer 
      patients (p<0.05). There were no deaths in the GGN non-cancer group (n=60) within 
      3 years, while 43 deaths occurred in GGN lung cancer group. The median survival 
      time and the 3-year survival rate of patients with p53 positive was lower than 
      that of p53-negative patients (p<0.05). p53 was overexpressed in GGN of lung 
      cancer patients, and p53 overexpression is significantly correlated with poor 
      prognosis of lung cancer patients. p53 plays an important role in transformation 
      from GGN to lung cancer. Detection of p53 expression in GGN tissue may provide 
      guidance for the diagnosis and prognosis of lung cancer.
FAU - Teng, Zhihua
AU  - Teng Z
AD  - Department of Thoracic Surgery, The Second Affiliated Hospital of Zhejiang 
      University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.
FAU - Chen, Wen
AU  - Chen W
AD  - Department of TCM, The Second Affiliated Hospital of Fujian Medical University, 
      Respiratory Medicine Center of Fujian Province, Quanzhou, Fujian 362000, P.R. 
      China.
FAU - Yang, Dongyong
AU  - Yang D
AD  - Department of Pulmonary and Critical Care Medicine, The Second Affiliated 
      Hospital of Fujian Medical University, Respiratory Medicine Center of Fujian 
      Province, Quanzhou, Fujian 362000, P.R. China.
FAU - Zhang, Zhenghua
AU  - Zhang Z
AD  - Department of Oncology, Jingan District Central Hospital, Shanghai 200040, P.R. 
      China.
FAU - Zhu, Lifei
AU  - Zhu L
AD  - Center of Cancer, Shanghai General Hospital, Shanghai Jiao Tong University, 
      Shanghai 201620, P.R. China.
FAU - Wu, Fubing
AU  - Wu F
AD  - Department of Medical Oncology, Sir Run Run Hospital, Nanjing Medical University, 
      Nanjing, Jiangsu 211166, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20181205
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6341667
OTO - NOTNLM
OT  - ground-glass nodule
OT  - lung cancer
OT  - p53
OT  - prognosis
EDAT- 2019/01/25 06:00
MHDA- 2019/01/25 06:01
PMCR- 2018/12/05
CRDT- 2019/01/25 06:00
PHST- 2018/05/19 00:00 [received]
PHST- 2018/11/16 00:00 [accepted]
PHST- 2019/01/25 06:00 [entrez]
PHST- 2019/01/25 06:00 [pubmed]
PHST- 2019/01/25 06:01 [medline]
PHST- 2018/12/05 00:00 [pmc-release]
AID - OL-0-0-9797 [pii]
AID - 10.3892/ol.2018.9797 [doi]
PST - ppublish
SO  - Oncol Lett. 2019 Feb;17(2):1559-1564. doi: 10.3892/ol.2018.9797. Epub 2018 Dec 5.