PMID- 30677468
OWN - NLM
STAT- MEDLINE
DCOM- 20190924
LR  - 20210816
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 92
DP  - 2019 Jun 8
TI  - Estrogen receptor 1 gene variants and estradiol activities in alcohol dependence.
PG  - 301-307
LID - S0278-5846(18)30611-0 [pii]
LID - 10.1016/j.pnpbp.2019.01.008 [doi]
AB  - OBJECTIVE: Alcohol use disorders inflict a great individual and societal burden. 
      Although sex hormone effects have been implicated in alcohol dependence, research 
      has mostly neglected estrogen activities and female alcohol-dependent patients. 
      Here, we investigated associations of estrogen receptor 1 (ESR1) genetics and 
      serum estradiol activities with aspects of alcohol dependence. METHOD: Serum 
      estradiol activities of early-abstinent alcohol-dependent in-patients 
      (n[male symbol] = 113, n[female symbol] = 87) were followed for at median 5 days and compared with 
      healthy controls (n[male symbol] = 133, n[female symbol] = 107). All participants were genotyped for 
      five ESR1 single nucleotide polymorphisms (rs6902771, rs11155819, rs6557171, 
      rs2982683, rs2982712). RESULTS: Bioavailable estradiol levels decreased during 
      withdrawal treatment (P[male symbol] < .001, P[female symbol] = .011). Male patients with an increase 
      of bioavailable estradiol during withdrawal showed fewer days to (P = .033) and 
      more alcohol-related readmissions (P < .05) during the 12-month follow-up. Higher 
      estradiol and estradiol-to-testosterone activities were significantly related to 
      liver, muscle, and cell count damage in male patients. Estradiol-to-testosterone 
      activities in female patients were lower compared to female controls (total 
      P = .013, bioavailable P = .009). Moreover, the ESR1 genotypes jointly separated 
      alcohol-dependent patients from controls (P = .037). CONCLUSION: Our findings 
      support the role of ESR1 genetics in alcohol dependence and show for the first 
      time that estradiol activities may sex-specifically predict alcohol-related 
      sequelae and outcome following in-patient withdrawal treatment.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Muhle, Christiane
AU  - Muhle C
AD  - Department of Psychiatry and Psychotherapy, Friedrich-Alexander University 
      Erlangen-Nurnberg (FAU), Germany. Electronic address: 
      christiane.muehle@uk-erlangen.de.
FAU - Barry, Brianna
AU  - Barry B
AD  - Department of Psychiatry and Psychotherapy, Friedrich-Alexander University 
      Erlangen-Nurnberg (FAU), Germany. Electronic address: bbarry3@jhmi.edu.
FAU - Weinland, Christian
AU  - Weinland C
AD  - Department of Psychiatry and Psychotherapy, Friedrich-Alexander University 
      Erlangen-Nurnberg (FAU), Germany. Electronic address: 
      christian.weinland@uk-erlangen.de.
FAU - Kornhuber, Johannes
AU  - Kornhuber J
AD  - Department of Psychiatry and Psychotherapy, Friedrich-Alexander University 
      Erlangen-Nurnberg (FAU), Germany. Electronic address: 
      johannes.kornhuber@uk-erlangen.de.
FAU - Lenz, Bernd
AU  - Lenz B
AD  - Department of Psychiatry and Psychotherapy, Friedrich-Alexander University 
      Erlangen-Nurnberg (FAU), Germany. Electronic address: bernd.lenz@uk-erlangen.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190121
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
RN  - 3XMK78S47O (Testosterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Adult
MH  - Alcoholism/blood/*genetics
MH  - Case-Control Studies
MH  - Estradiol/*blood
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Inpatients
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Sex Characteristics
MH  - Substance Withdrawal Syndrome/blood
MH  - Testosterone/blood
OTO - NOTNLM
OT  - Alcohol dependence
OT  - Bioavailable fraction
OT  - Estradiol
OT  - Estrogen receptor 1 gene
OT  - Readmission
OT  - Sex-differences
EDAT- 2019/01/25 06:00
MHDA- 2019/09/26 06:00
CRDT- 2019/01/25 06:00
PHST- 2018/08/07 00:00 [received]
PHST- 2018/12/29 00:00 [revised]
PHST- 2019/01/20 00:00 [accepted]
PHST- 2019/01/25 06:00 [pubmed]
PHST- 2019/09/26 06:00 [medline]
PHST- 2019/01/25 06:00 [entrez]
AID - S0278-5846(18)30611-0 [pii]
AID - 10.1016/j.pnpbp.2019.01.008 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8;92:301-307. doi: 
      10.1016/j.pnpbp.2019.01.008. Epub 2019 Jan 21.