PMID- 30677951
OWN - NLM
STAT- MEDLINE
DCOM- 20190214
LR  - 20190215
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 657
DP  - 2019 Mar 20
TI  - Decreased plasma levels of perfluoroalkylated substances one year after bariatric 
      surgery.
PG  - 863-870
LID - S0048-9697(18)34808-3 [pii]
LID - 10.1016/j.scitotenv.2018.11.453 [doi]
AB  - Per- and polyfluoroalkylated substances (PFASs) are classified as persistent 
      organic pollutants (POPs), and known to be protein bound. The aim of the present 
      study was to determine the levels of 17 different PFASs before and one year after 
      bariatric surgery, and to assess whether weight loss and changed serum protein 
      concentrations could be influencing factors. Plasma samples from 63 patients were 
      analyzed for nine perfluoroalkyl carboxylic acids (PFCAs), three perfluoroalkane 
      sulfonic acids (PFSAs), and five perfluoroalkyl sulfonamide based substances 
      (PASF) before and after surgery. Protein determination was performed in the 
      corresponding serum samples. Mean weight loss one year after surgery was 32.1 kg. 
      The plasma levels of all PFASs decreased with 4-34% compared to preoperative 
      values, and included perfluorononanoic acid (PFNA), perfluorodecanoic acid 
      (PFDA), perfluoroundecanoic acid (PFUnDA), and perfluorobutane sulfonate (PFBS), 
      which have been identified with increasing levels in the general population 
      during recent years. Serum protein concentrations also decreased with 7-8%. 
      Although protein levels were positively correlated with PFOA, PFBS, PFHxS and 
      PFOS, regression analysis revealed that neither weight loss nor reductions in 
      concentrations of serum protein could explain the decreased PFAS levels. The type 
      of surgical procedure did not influence the changes of PFAS levels between the 
      two sample points. A reduced food intake and alterations in absorptions of 
      nutrients after bariatric surgery may have influenced the observed decreasing 
      plasma levels of PFASs.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Jansen, Aina
AU  - Jansen A
AD  - Department of Surgery, Innlandet Hospital Trust, Gjovik, Norway; Department of 
      Food Safety and Infection Biology, Norwegian University of Life Sciences (NMBU), 
      Oslo, Norway. Electronic address: aina.jansen@sykehuset-innlandet.no.
FAU - Muller, Mette H B
AU  - Muller MHB
AD  - Department of Food Safety and Infection Biology, Norwegian University of Life 
      Sciences (NMBU), Oslo, Norway.
FAU - Gronnestad, Randi
AU  - Gronnestad R
AD  - Department of Food Safety and Infection Biology, Norwegian University of Life 
      Sciences (NMBU), Oslo, Norway; Department of Biology, Norwegian University of 
      Science and Technology (NTNU), Trondheim, Norway.
FAU - Klungsoyr, Ole
AU  - Klungsoyr O
AD  - Oslo Centre for Biostatistics and Epidemiology, Section for Treatment Research, 
      Department for Research and Education, Division of Mental Health and Addiction, 
      Oslo University Hospital, Oslo, Norway.
FAU - Polder, Anuschka
AU  - Polder A
AD  - Department of Food Safety and Infection Biology, Norwegian University of Life 
      Sciences (NMBU), Oslo, Norway.
FAU - Skjerve, Eystein
AU  - Skjerve E
AD  - Centre for Epidemiology and Biostatistics, Norwegian University of Life Sciences 
      (NMBU), Oslo, Norway.
FAU - Aaseth, Jan
AU  - Aaseth J
AD  - Innlandet Hospital Trust, Research Department, Brumunddal, Norway; Faculty of 
      Health and Social Sciences, Inland Norway University of Applied Sciences, 
      Elverum, Norway.
FAU - Lyche, Jan L
AU  - Lyche JL
AD  - Department of Food Safety and Infection Biology, Norwegian University of Life 
      Sciences (NMBU), Oslo, Norway.
LA  - eng
PT  - Journal Article
DEP - 20181203
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Carboxylic Acids)
RN  - 0 (Decanoic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Sulfonic Acids)
RN  - 335-76-2 (perfluorodecanoic acid)
RN  - SE4TWR0K2C (perfluorobutane)
SB  - IM
MH  - Adult
MH  - *Bariatric Surgery
MH  - Body Mass Index
MH  - Carboxylic Acids/blood
MH  - Decanoic Acids/blood
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Fluorocarbons/blood
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Sulfonic Acids/blood
OTO - NOTNLM
OT  - Albumin
OT  - Bariatric surgery
OT  - Obesity
OT  - Perfluoroalkylated substances
OT  - Total protein
OT  - Weight loss
EDAT- 2019/01/27 06:00
MHDA- 2019/02/15 06:00
CRDT- 2019/01/26 06:00
PHST- 2018/10/01 00:00 [received]
PHST- 2018/11/24 00:00 [revised]
PHST- 2018/11/29 00:00 [accepted]
PHST- 2019/01/26 06:00 [entrez]
PHST- 2019/01/27 06:00 [pubmed]
PHST- 2019/02/15 06:00 [medline]
AID - S0048-9697(18)34808-3 [pii]
AID - 10.1016/j.scitotenv.2018.11.453 [doi]
PST - ppublish
SO  - Sci Total Environ. 2019 Mar 20;657:863-870. doi: 10.1016/j.scitotenv.2018.11.453. 
      Epub 2018 Dec 3.