PMID- 30678124
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231006
IS  - 1996-1944 (Print)
IS  - 1996-1944 (Electronic)
IS  - 1996-1944 (Linking)
VI  - 12
IP  - 3
DP  - 2019 Jan 23
TI  - A Systematic Study of the Effect of pH on the Initialization of Ca-deficient 
      Hydroxyapatite to beta-TCP Nanoparticles.
LID - 10.3390/ma12030354 [doi]
LID - 354
AB  - The formation of beta-tricalcium phosphate (beta-TCP) nanoparticles via a wet 
      precipitation technique was studied in a systematical way, taking reaction pH and 
      sintering temperature parameters into account. A full transformation of 
      Ca-deficient hydroxyapatite (CDHA) to beta-TCP at 750  degrees C in under 3 hours from 
      Ca(++) and PO(4)(3-) precursor solutions prepared under a pH of 5.5 was observed. 
      For pH values higher than 6.5, CDHA can only partially transform into beta-TCP and 
      only at temperatures higher than 750  degrees C confirmed using X-Ray diffraction and 
      Raman spectroscopy. The morphologies of the particles were also examined by 
      Transmission electron microscopy. The lower temperatures and the shorter 
      sintering time allow for a fine needle-like morphology, but with a high 
      crystallinity, likely eliminating the possibility of excessive grain growth that 
      is otherwise expected to occur under high-temperature treatment with long process 
      times. We show that sintering of nanostructured, high crystallinity beta-TCP at 
      relatively low temperatures is possible via adjustment of the precursor solution 
      parameters. Such an outcome is important for the use of beta-TCP with a fine 
      morphology imitating that of the skeletal tissues, enhancing the osteointegration 
      of a base, load-bearing alloy to the host tissue. MTT analysis was used to test 
      the effect of the obtained beta-TCP particles on the viability of MG-63 human 
      osteoblast-like cells.
FAU - Bakan, Feray
AU  - Bakan F
AUID- ORCID: 0000-0001-6467-8943
AD  - Sabanci University SUNUM Nanotechnology Research Center, TR-34956 Istanbul, 
      Turkey. feraybakan@sabanciuniv.edu.
LA  - eng
PT  - Journal Article
DEP - 20190123
PL  - Switzerland
TA  - Materials (Basel)
JT  - Materials (Basel, Switzerland)
JID - 101555929
PMC - PMC6384749
OTO - NOTNLM
OT  - Ca-deficient hydroxyapatite
OT  - nanobiomaterials
OT  - nanocharacterization
OT  - wet chemical precipitation
OT  - beta-tricalcium phosphate
COIS- The authors declare no conflict of interest.
EDAT- 2019/01/27 06:00
MHDA- 2019/01/27 06:01
PMCR- 2019/01/23
CRDT- 2019/01/26 06:00
PHST- 2019/01/01 00:00 [received]
PHST- 2019/01/20 00:00 [revised]
PHST- 2019/01/22 00:00 [accepted]
PHST- 2019/01/26 06:00 [entrez]
PHST- 2019/01/27 06:00 [pubmed]
PHST- 2019/01/27 06:01 [medline]
PHST- 2019/01/23 00:00 [pmc-release]
AID - ma12030354 [pii]
AID - materials-12-00354 [pii]
AID - 10.3390/ma12030354 [doi]
PST - epublish
SO  - Materials (Basel). 2019 Jan 23;12(3):354. doi: 10.3390/ma12030354.