PMID- 30678315
OWN - NLM
STAT- MEDLINE
DCOM- 20190423
LR  - 20200225
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 24
IP  - 3
DP  - 2019 Jan 22
TI  - CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the 
      Centromere.
LID - 10.3390/molecules24030402 [doi]
LID - 402
AB  - The centromere plays an essential role in accurate chromosome segregation, and 
      the chromosomal location of the centromere is determined by the presence of a 
      histone H3 variant, centromere protein A (CENP-A), in centromeric nucleosomes. 
      However, the precise mechanisms of deposition, maintenance, and inheritance of 
      CENP-A at centromeres are unclear. We have reported that CENP-A deposition 
      requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity 
      of Cullin 4A (CUL4A)-RING-box protein 1 (RBX1)-COP9 signalsome complex subunit 8 
      (COPS8). We have proposed a model of inheritance for CENP-A ubiquitylation, 
      through dimerization between rounds of cell divisions, that maintains the 
      position of centromeres.
FAU - Niikura, Yohei
AU  - Niikura Y
AD  - Greehey Children's Cancer Research Institute, Department of Molecular Medicine, 
      UT Health Science Center San Antonio School of Medicine, 8403 Floyd Curl Drive, 
      San Antonio, TX 78229-3000, USA. niikura@nicemice.cn.
AD  - MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research 
      Center, Nanjing University, Nanjing 210061, China. niikura@nicemice.cn.
FAU - Kitagawa, Risa
AU  - Kitagawa R
AD  - Greehey Children's Cancer Research Institute, Department of Molecular Medicine, 
      UT Health Science Center San Antonio School of Medicine, 8403 Floyd Curl Drive, 
      San Antonio, TX 78229-3000, USA. kitagawaR@uthscsa.edu.
FAU - Kitagawa, Katsumi
AU  - Kitagawa K
AD  - Greehey Children's Cancer Research Institute, Department of Molecular Medicine, 
      UT Health Science Center San Antonio School of Medicine, 8403 Floyd Curl Drive, 
      San Antonio, TX 78229-3000, USA. kitagawaK@uthscsa.edu.
LA  - eng
GR  - R21 CA205659/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20190122
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Centromere Protein A)
SB  - IM
MH  - Centromere/genetics/*metabolism
MH  - Centromere Protein A/*metabolism
MH  - Epigenesis, Genetic
MH  - HeLa Cells
MH  - Humans
MH  - Models, Biological
MH  - Protein Binding
MH  - Ubiquitination
PMC - PMC6384693
OTO - NOTNLM
OT  - CENP-A
OT  - CUL4A-RBX1- COPS8 E3 ligase
OT  - centromere
OT  - centromere identity
OT  - dimerization
OT  - epigenetics
OT  - kinetochore
OT  - lysine 124 (K124), neocentromere
OT  - ubiquitylation
COIS- The authors declare no conflict of interest.
EDAT- 2019/01/27 06:00
MHDA- 2019/04/24 06:00
PMCR- 2019/01/22
CRDT- 2019/01/26 06:00
PHST- 2018/12/14 00:00 [received]
PHST- 2019/01/15 00:00 [revised]
PHST- 2019/01/20 00:00 [accepted]
PHST- 2019/01/26 06:00 [entrez]
PHST- 2019/01/27 06:00 [pubmed]
PHST- 2019/04/24 06:00 [medline]
PHST- 2019/01/22 00:00 [pmc-release]
AID - molecules24030402 [pii]
AID - molecules-24-00402 [pii]
AID - 10.3390/molecules24030402 [doi]
PST - epublish
SO  - Molecules. 2019 Jan 22;24(3):402. doi: 10.3390/molecules24030402.