PMID- 30680016
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 17
IP  - 2
DP  - 2019 Feb
TI  - Correlation between IL-4 and IL-13 gene polymorphisms and asthma in Uygur 
      children in Xinjiang.
PG  - 1374-1382
LID - 10.3892/etm.2018.7096 [doi]
AB  - Correlation between interleukin-4 (IL-4) and interleukin-13 (IL-13) gene 
      polymorphisms and bronchial asthma in Uygur children in Xinjiang, China, and the 
      effects on serum total immunoglobulin E (IgE) were investigated. Thirty-seven 
      child patients with asthma and 29 healthy children were screened. The gene 
      polymorphisms of Arg130Gln in IL-13 and -590C/T in IL-4 gene promoter region were 
      analyzed using the polymerase chain reaction (PCR) and direct gene sequencing; 
      the asthma-related indexes were detected using the enzyme-linked immunosorbent 
      assay, and the relevant indexes were analyzed; moreover, whether there was a 
      synergistic effect between Arg130Gln in IL-13 and -590C/T in IL-4 gene promoter 
      region in the pathogenesis of asthma in children was analyzed. The T/T homozygote 
      genotype frequency and T allele frequency of C-590T gene in IL-4 in the asthma 
      group were significantly higher than those in the control group (45.9 vs. 10.3%, 
      OR=8.91; 63.5 vs. 36.2%, OR=3.07, P<0.05). The A/A genotype frequency and A 
      allele frequency of Arg130Gln locus in IL-13 in the asthma group were obviously 
      higher than those in the control group (54.1 vs. 17.2%, OR=6.29; 67.6 vs. 39.7%, 
      OR=3.17, P<0.05). In the two gene loci, the level of serum IgE in the same 
      genotype in the asthma group was higher than that in the control group (Z=-2.128, 
      -2.050, -2.700 vs. -3.766, -3.799, -3.397; P<0.05). The risk of asthma in 
      carriers of both IL-4 -590C/T TT and Arg130Gln locus AA genotypes was 
      significantly increased compared with that in carriers of either IL-4 -590C/T TT 
      genotype or Arg130Gln locus AA genotype (OR=6.00, P=0.046; OR=4.50, P=0.033; 
      OR=22, P=0.005). The IL-4 -590C/T and Arg130Gln locus gene polymorphisms are 
      associated with the asthma susceptibility and increased serum total IgE in Uygur 
      children in Xinjiang. There is a synergistic effect between the T allele of IL-4 
      -590C/T locus and the A allele of IL-13 Arg130Gln locus.
FAU - Zhang, Ji-Hong
AU  - Zhang JH
AD  - Department of Paediatrics, The Affiliated Yangpu Hospital of Shanghai Tongji 
      University, Shanghai 200090, P.R. China.
FAU - Zhang, Mei
AU  - Zhang M
AD  - Department of Paediatrics, The First Affiliated Hospital of Xinjiang Medical 
      University, Xinjiang, Uygur Autonomous Region 830054, P.R. China.
FAU - Wang, Ya-Nan
AU  - Wang YN
AD  - Department of Paediatrics, Xinjiang Medical University, Xinjiang, Uygur 
      Autonomous Region 830011, P.R. China.
FAU - Zhang, Xiao-Ying
AU  - Zhang XY
AD  - Department of Paediatrics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200011, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20181213
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6327510
OTO - NOTNLM
OT  - IL-13
OT  - IL-4
OT  - IgE
OT  - asthma
OT  - children
OT  - gene polymorphism
EDAT- 2019/01/27 06:00
MHDA- 2019/01/27 06:01
PMCR- 2018/12/13
CRDT- 2019/01/26 06:00
PHST- 2018/06/07 00:00 [received]
PHST- 2018/11/13 00:00 [accepted]
PHST- 2019/01/26 06:00 [entrez]
PHST- 2019/01/27 06:00 [pubmed]
PHST- 2019/01/27 06:01 [medline]
PHST- 2018/12/13 00:00 [pmc-release]
AID - ETM-0-0-7096 [pii]
AID - 10.3892/etm.2018.7096 [doi]
PST - ppublish
SO  - Exp Ther Med. 2019 Feb;17(2):1374-1382. doi: 10.3892/etm.2018.7096. Epub 2018 Dec 
      13.