PMID- 30680203
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2049-9450 (Print)
IS  - 2049-9469 (Electronic)
IS  - 2049-9450 (Linking)
VI  - 10
IP  - 2
DP  - 2019 Feb
TI  - Poorly differentiated pulmonary synovial sarcoma with SYT gene amplification: A 
      case report.
PG  - 249-252
LID - 10.3892/mco.2018.1787 [doi]
AB  - Fluorescence in situ hybridization (FISH) and reverse-transcription polymerase 
      chain reaction (RT-PCR) analysis may be used for the diagnosis of synovial 
      sarcoma (SS), particularly of the poorly differentiated type. While the majority 
      of the studies report that the SYT FISH probe is considered to be break-apart in 
      SS, with two orange and two green signals, the SYT probe in the present case of a 
      52-year-old male patient with pulmonary SS displayed orange and green signal 
      separation, along with SYT orange signal amplification. RT-PCR was used to verify 
      that the SYT gene amplification was another form of expression of SYT-SSX gene 
      fusion t(X; 18)(p11; q11). In this case, the tumour sample obtained by biopsy was 
      small; therefore, the definitive diagnosis of poorly differentiated SS 
      originating from the lung with SYT gene amplification was confirmed by FISH and 
      RT-PCR. Therefore, these mature biomarkers, which are available as 
      immunohistochemical stains in the molecular pathology laboratory, may help 
      pathologists to diagnose intractable soft tissue tumours based only on small 
      cytological specimens.
FAU - Li, Xiaoyan
AU  - Li X
AD  - Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian 
      350001, P.R. China.
FAU - Wu, Dan
AU  - Wu D
AD  - Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian 
      350001, P.R. China.
FAU - Zheng, Yuhui
AU  - Zheng Y
AD  - Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian 
      350001, P.R. China.
FAU - Yang, Huanxing
AU  - Yang H
AD  - Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian 
      350001, P.R. China.
FAU - Yang, Yinghong
AU  - Yang Y
AD  - Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian 
      350001, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20181207
PL  - England
TA  - Mol Clin Oncol
JT  - Molecular and clinical oncology
JID - 101613422
PMC - PMC6327209
OTO - NOTNLM
OT  - SYT gene
OT  - fluorescence in situ hybridization
OT  - lung
OT  - reverse transcription-polymerase chain reaction
OT  - synovial sarcoma
EDAT- 2019/01/27 06:00
MHDA- 2019/01/27 06:01
PMCR- 2018/12/07
CRDT- 2019/01/26 06:00
PHST- 2018/09/07 00:00 [received]
PHST- 2018/11/21 00:00 [accepted]
PHST- 2019/01/26 06:00 [entrez]
PHST- 2019/01/27 06:00 [pubmed]
PHST- 2019/01/27 06:01 [medline]
PHST- 2018/12/07 00:00 [pmc-release]
AID - MCO-0-0-1787 [pii]
AID - 10.3892/mco.2018.1787 [doi]
PST - ppublish
SO  - Mol Clin Oncol. 2019 Feb;10(2):249-252. doi: 10.3892/mco.2018.1787. Epub 2018 Dec 
      7.