PMID- 30680742
OWN - NLM
STAT- MEDLINE
DCOM- 20190705
LR  - 20190705
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 59
IP  - 4
DP  - 2019 Apr
TI  - Electrophysiological determinants of the clinical severity of axonal peripheral 
      neuropathy.
PG  - 491-493
LID - 10.1002/mus.26425 [doi]
AB  - INTRODUCTION: Electrophysiological diagnosis of axonal peripheral neuropathy (PN) 
      is based on the attenuated amplitudes of nerve conduction studies (NCS), or a 
      reduced sural/radial amplitude ratio (SRAR). We aimed to identify the 
      electrophysiological determinants of the clinical severity of PN. METHODS: 
      Patients with chronic axonal PN underwent detailed NCS. The clinical severity of 
      PN was determined based upon the overall neuropathy limitations scale (ONLS). 
      RESULTS: Ninety-five patients (71.6% males, mean age 71.9 +/- 9.0 years) were 
      recruited. Significant correlations were observed between the radial sensory 
      nerve action potential (SNAP) and the ONLS total score (Spearman's rho -0.382, 
      p < 0.001); and between the tibial compound muscle action potential and the ONLS 
      leg score (Spearman's rho -0.283, p = 0.005). No correlations between the SRAR 
      and the ONLS scores were found. DISCUSSION: The radial SNAP is the strongest 
      electrophysiological determinant of PN severity and might be useful for 
      monitoring disease progression or response to treatment. Muscle Nerve 59:491-493, 
      2019.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Zis, Panagiotis
AU  - Zis P
AUID- ORCID: 0000-0001-8567-3092
AD  - Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation 
      Trust.
FAU - Hadjivassiliou, Marios
AU  - Hadjivassiliou M
AD  - Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation 
      Trust.
FAU - Rao, Dasappaiah Ganesh
AU  - Rao DG
AD  - Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation 
      Trust.
FAU - Sarrigiannis, Ptolemaios Georgios
AU  - Sarrigiannis PG
AD  - Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation 
      Trust.
LA  - eng
PT  - Journal Article
DEP - 20190211
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Action Potentials
MH  - Aged
MH  - Aged, 80 and over
MH  - Axons
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Electromyography
MH  - *Electrophysiological Phenomena
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neural Conduction
MH  - Peripheral Nervous System Diseases/*physiopathology
MH  - Radial Nerve/physiopathology
MH  - Sural Nerve/physiopathology
OTO - NOTNLM
OT  - SRAR
OT  - electrodiagnostic
OT  - polyneuropathy
OT  - radial nerve
OT  - scale
OT  - severity
EDAT- 2019/01/27 06:00
MHDA- 2019/07/06 06:00
CRDT- 2019/01/26 06:00
PHST- 2018/03/20 00:00 [received]
PHST- 2019/01/15 00:00 [revised]
PHST- 2019/01/19 00:00 [accepted]
PHST- 2019/01/27 06:00 [pubmed]
PHST- 2019/07/06 06:00 [medline]
PHST- 2019/01/26 06:00 [entrez]
AID - 10.1002/mus.26425 [doi]
PST - ppublish
SO  - Muscle Nerve. 2019 Apr;59(4):491-493. doi: 10.1002/mus.26425. Epub 2019 Feb 11.