PMID- 30683471
OWN - NLM
STAT- MEDLINE
DCOM- 20190621
LR  - 20190621
IS  - 1532-818X (Electronic)
IS  - 0196-0709 (Linking)
VI  - 40
IP  - 2
DP  - 2019 Mar-Apr
TI  - Nuclear expression of onco-suppressors nm23-H1 and maspin are associated with 
      lower recurrence rate in laryngeal carcinoma.
PG  - 224-229
LID - S0196-0709(18)30947-5 [pii]
LID - 10.1016/j.amjoto.2018.11.007 [doi]
AB  - PURPOSE: The main aim of the study was to preliminarily investigate the possibly 
      related role of nuclear onco-suppressors maspin and nm23-H1, a metastasis 
      suppressor, in laryngeal squamous cell carcinoma (LSCC). MATERIALS AND METHODS: 
      Maspin expression pattern and nuclear nm23-H1 expression were ascertained in 62 
      consecutive LSCCs. RESULTS: Recurrence rate was significantly lower in patients 
      with a nuclear maspin pattern of expression; nuclear nm23-H1 expression was 
      significantly lower in patients who experienced disease recurrence. Disease free 
      survival (DFS) was significantly longer in patients with maspin nuclear pattern 
      or with nuclear nm23-H1 expression >/=10%. A significant association was found 
      between nuclear nm23-H1 expression and maspin pattern of expression in LSCC. KNN 
      discriminant analysis considered N status, maspin sub-cellular localization and 
      nuclear nm23-H1 expression. The selected variables' accuracy in terms of relapse 
      was 82%. Positive predictive accuracy was 100%, and negative predictive accuracy 
      79%. CONCLUSIONS: Nuclear nm23-H1 expression and maspin pattern, also in 
      association, show promise as recurrence indicators in LSCC. Further studies are 
      needed to shed more light on the nm23-H1 mechanism of action in LSCC and thus 
      find ways to restore nm23-H1 loss. These preliminary findings suggest that 
      re-activating maspin functions might represent an important goal in the treatment 
      of advanced LSCC.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Marioni, Gino
AU  - Marioni G
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 
      Padova, Italy. Electronic address: gino.marioni@unipd.it.
FAU - Ottaviano, Giancarlo
AU  - Ottaviano G
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 
      Padova, Italy.
FAU - de Filippis, Cosimo
AU  - de Filippis C
AD  - Department of Neuroscience DNS, Audiology Unit, University of Padova, Treviso, 
      Italy.
FAU - Fasanaro, Elena
AU  - Fasanaro E
AD  - Radiotherapy Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy.
FAU - Randon, Benedetto
AU  - Randon B
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 
      Padova, Italy.
FAU - Meneghesso, Stefano
AU  - Meneghesso S
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 
      Padova, Italy.
FAU - Giacomelli, Luciano
AU  - Giacomelli L
AD  - Department of Medicine DIMED, University of Padova, Padova, Italy.
FAU - Astolfi, Laura
AU  - Astolfi L
AD  - Department of Neuroscience DNS, Bioacoustics Research Laboratory, University of 
      Padova, Padova, Italy.
FAU - Blandamura, Stella
AU  - Blandamura S
AD  - Department of Medicine DIMED, University of Padova, Padova, Italy.
LA  - eng
PT  - Journal Article
DEP - 20181122
PL  - United States
TA  - Am J Otolaryngol
JT  - American journal of otolaryngology
JID - 8000029
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (NM23 Nucleoside Diphosphate Kinases)
RN  - 0 (SERPIN-B5)
RN  - 0 (Serpins)
RN  - EC 2.7.4.6 (NME1 protein, human)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma, Squamous Cell/*genetics/therapy
MH  - Female
MH  - *Gene Expression
MH  - *Genes, Tumor Suppressor
MH  - *Genetic Association Studies
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/therapy
MH  - Male
MH  - Middle Aged
MH  - Molecular Targeted Therapy
MH  - NM23 Nucleoside Diphosphate Kinases/*genetics/*metabolism
MH  - Neoplasm Recurrence, Local/*epidemiology/*genetics
MH  - Predictive Value of Tests
MH  - Serpins/*genetics/*metabolism
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma
OT  - Maspin
OT  - Nuclear
OT  - Tumor suppressors
OT  - nm23-H1
EDAT- 2019/01/27 06:00
MHDA- 2019/06/22 06:00
CRDT- 2019/01/27 06:00
PHST- 2018/10/10 00:00 [received]
PHST- 2018/11/20 00:00 [accepted]
PHST- 2019/01/27 06:00 [pubmed]
PHST- 2019/06/22 06:00 [medline]
PHST- 2019/01/27 06:00 [entrez]
AID - S0196-0709(18)30947-5 [pii]
AID - 10.1016/j.amjoto.2018.11.007 [doi]
PST - ppublish
SO  - Am J Otolaryngol. 2019 Mar-Apr;40(2):224-229. doi: 10.1016/j.amjoto.2018.11.007. 
      Epub 2018 Nov 22.