PMID- 30683524 OWN - NLM STAT- MEDLINE DCOM- 20200928 LR - 20200928 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 210 DP - 2019 Aug TI - The interrelationship between schizotypy, clinical high risk for psychosis and related symptoms: Cognitive disturbances matter. PG - 188-196 LID - S0920-9964(18)30734-5 [pii] LID - 10.1016/j.schres.2018.12.039 [doi] AB - Schizotypy and clinical high risk (CHR) criteria can identify individuals who are at increased risk for developing psychosis in community and patient samples. However, both approaches have rarely been combined, and very little is known about their associations. Therefore, we examined the factorial structure of CHR and related symptoms and schizotypy features as well as their interrelationship for the first time in a comprehensive approach. In a sample of 277 patients (22 +/- 6 years) from two early detection services, structural equation modeling including confirmatory factor analysis was performed to test a theory-driven model using four Wisconsin Schizotypy Scales, 14 predictive basic symptoms (BS) of the Schizophrenia Proneness Instrument, and positive, negative, and disorganized symptoms from the Structured Interview for Psychosis-Risk Syndromes. The data fitted well to the six hypothesized latent factors consisting of negative schizotypy, positive schizotypy including perceptual BS, negative symptoms, positive symptoms, disorganized symptoms and cognitive disturbances. As postulated, schizotypy features were significantly associated with positive, negative and disorganized symptoms through cognitive disturbances. Additionally, positive and negative schizotypy also had a direct association with the respective symptom-domain. While the identified factorial structure corresponds well to dimensional models of schizotypy and psychoses, our model extends earlier models by indicating that schizotypy features are associated with positive, negative and disorganized symptoms directly or indirectly via subjective cognitive disturbances. This calls for more attention to subjective cognitive deficits in combination with heightened schizotypy in the early detection and intervention of psychoses - or even of an Attenuated Psychosis Syndrome. CI - Copyright (c) 2019 Elsevier B.V. All rights reserved. FAU - Fluckiger, Rahel AU - Fluckiger R AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: rahel.flueckiger@upd.unibe.ch. FAU - Michel, Chantal AU - Michel C AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: chantal.michel@upd.unibe.ch. FAU - Grant, Phillip AU - Grant P AD - Psychology School, Faculty of Health and Social Sciences, Fresenius University of Applied Sciences, Marienburgstr. 6, 60528 Frankfurt am Main, Germany; Faculty of Life Science Engineering, Technische Hochschule Mittelhessen University of Applied Sciences, Wiesenstr. 14, 35390 Giessen, Germany. Electronic address: phillip.grant@hs-fresenius.de. FAU - Ruhrmann, Stephan AU - Ruhrmann S AD - Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50937 Koln, Germany. Electronic address: stephan.ruhrmann@uk-koeln.de. FAU - Vogeley, Kai AU - Vogeley K AD - Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50937 Koln, Germany. Electronic address: kai.vogeley@uk-koeln.de. FAU - Hubl, Daniela AU - Hubl D AD - University Hospital of Psychiatry and Psychotherapy, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: daniela.hubl@upd.unibe.ch. FAU - Schimmelmann, Benno G AU - Schimmelmann BG AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland; University Hospital of Child and Adolescent Psychiatry, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. Electronic address: benno.schimmelmann@upd.unibe.ch. FAU - Klosterkotter, Joachim AU - Klosterkotter J AD - Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50937 Koln, Germany. Electronic address: joachim.klosterkoetter@uk-koeln.de. FAU - Schmidt, Stefanie J AU - Schmidt SJ AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland; Department of Clinical Psychology and Psychotherapy, University of Bern, Fabrikstrasse 8, 3012 Bern, Switzerland. Electronic address: stefanie.schmidt@psy.unibe.ch. FAU - Schultze-Lutter, Frauke AU - Schultze-Lutter F AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland; Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Bergische Landstrasse 2, 40629 Dusseldorf, Germany. Electronic address: frauke.schultze-lutter@lvr.de. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190122 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Adolescent MH - Adult MH - Cognitive Dysfunction/etiology/*physiopathology MH - Diagnostic Self Evaluation MH - Early Diagnosis MH - Female MH - Humans MH - Male MH - Psychotic Disorders/complications/*physiopathology MH - Risk MH - Schizotypal Personality Disorder/complications/*physiopathology MH - Young Adult OTO - NOTNLM OT - Cognitive basic symptoms OT - Early detection OT - Schizophrenia OT - Structural equation modeling EDAT- 2019/01/27 06:00 MHDA- 2020/09/29 06:00 CRDT- 2019/01/27 06:00 PHST- 2018/04/03 00:00 [received] PHST- 2018/12/13 00:00 [revised] PHST- 2018/12/20 00:00 [accepted] PHST- 2019/01/27 06:00 [pubmed] PHST- 2020/09/29 06:00 [medline] PHST- 2019/01/27 06:00 [entrez] AID - S0920-9964(18)30734-5 [pii] AID - 10.1016/j.schres.2018.12.039 [doi] PST - ppublish SO - Schizophr Res. 2019 Aug;210:188-196. doi: 10.1016/j.schres.2018.12.039. Epub 2019 Jan 22.