PMID- 30683525
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 226
DP  - 2020 Dec
TI  - Relationships between cognitive event-related brain potential measures in 
      patients at clinical high risk for psychosis.
PG  - 84-94
LID - S0920-9964(19)30014-3 [pii]
LID - 10.1016/j.schres.2019.01.014 [doi]
AB  - Neurophysiological measures of cognitive functioning that are abnormal in 
      patients with schizophrenia are promising candidate biomarkers for predicting 
      development of psychosis in individuals at clinical high risk (CHR). We examined 
      the relationships among event-related brain potential (ERP) measures of early 
      sensory, pre-attentional, and attention-dependent cognition, in 
      antipsychotic-naive help-seeking CHR patients (n = 36) and healthy control 
      participants (n = 22). These measures included the gamma auditory steady-state 
      response (ASSR; early sensory); mismatch negativity (MMN) and P3a 
      (pre-attentional); and N400 semantic priming effects - a measure of using 
      meaningful context to predict related items - over a shorter and a longer time 
      interval (attention-dependent). Compared to controls, CHR patients had 
      significantly smaller P3a amplitudes (d = 0.62, p = 0.03) and N400 priming 
      effects over the long interval (d = 0.64, p = 0.02). In CHR patients, gamma ASSR 
      evoked power and phase-locking factor were correlated (r = 0.41, p = 0.03). 
      Reductions in mismatch negativity (MMN) and P3a amplitudes were also correlated 
      (r = -0.36, p = 0.04). Moreover, lower gamma ASSR evoked power correlated with 
      smaller MMN amplitudes (r = -0.45, p = 0.02). MMN amplitude reduction was also 
      associated with reduced N400 semantic priming over the shorter but not the longer 
      interval (r = 0.52, p < 0.002). This pattern of results suggests that, in a 
      subset of CHR patients, impairment in pre-attentional measures of early 
      information processing may contribute to deficits in attention-dependent 
      cognition involving rapid, more automatic processing, but may be independent from 
      pathological processes affecting more controlled or strategic processing. Thus, 
      combining neurophysiological indices of cognitive deficits in different domains 
      offers promise for improving their predictive power as prognostic biomarkers of 
      clinical outcome.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Lepock, Jennifer R
AU  - Lepock JR
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; 
      Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Ahmed, Sarah
AU  - Ahmed S
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; 
      Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Mizrahi, Romina
AU  - Mizrahi R
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; 
      Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of 
      Psychiatry, University of Toronto, Toronto, Ontario, Canada.
FAU - Gerritsen, Cory J
AU  - Gerritsen CJ
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Graduate 
      Department of Psychological Clinical Science, University of Toronto, Toronto, 
      Ontario, Canada.
FAU - Maheandiran, Margaret
AU  - Maheandiran M
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Drvaric, Lauren
AU  - Drvaric L
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; 
      Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Bagby, R Michael
AU  - Bagby RM
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; 
      Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of 
      Psychiatry, University of Toronto, Toronto, Ontario, Canada; Graduate Department 
      of Psychological Clinical Science, University of Toronto, Toronto, Ontario, 
      Canada.
FAU - Korostil, Michele
AU  - Korostil M
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of 
      Psychiatry, University of Toronto, Toronto, Ontario, Canada.
FAU - Light, Gregory A
AU  - Light GA
AD  - Department of Psychiatry, University of California, San Diego, La Jolla, CA, 
      United States.
FAU - Kiang, Michael
AU  - Kiang M
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; 
      Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of 
      Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: 
      michael.kiang@camh.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190122
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Brain
MH  - Cognition
MH  - *Electroencephalography
MH  - Evoked Potentials
MH  - Evoked Potentials, Auditory
MH  - Female
MH  - Humans
MH  - Male
MH  - *Psychotic Disorders/complications
OTO - NOTNLM
OT  - Clinical high risk
OT  - Cognition
OT  - Electroencephalography
OT  - Event-related potentials
OT  - Prodrome
OT  - Psychosis
EDAT- 2019/01/27 06:00
MHDA- 2021/06/22 06:00
CRDT- 2019/01/27 06:00
PHST- 2018/12/01 00:00 [received]
PHST- 2019/01/11 00:00 [revised]
PHST- 2019/01/14 00:00 [accepted]
PHST- 2019/01/27 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2019/01/27 06:00 [entrez]
AID - S0920-9964(19)30014-3 [pii]
AID - 10.1016/j.schres.2019.01.014 [doi]
PST - ppublish
SO  - Schizophr Res. 2020 Dec;226:84-94. doi: 10.1016/j.schres.2019.01.014. Epub 2019 
      Jan 22.