PMID- 30683847
OWN - NLM
STAT- MEDLINE
DCOM- 20200406
LR  - 20200602
IS  - 2041-4889 (Electronic)
VI  - 10
IP  - 2
DP  - 2019 Jan 25
TI  - LINC01939 inhibits the metastasis of gastric cancer by acting as a molecular 
      sponge of miR-17-5p to regulate EGR2 expression.
PG  - 70
LID - 10.1038/s41419-019-1344-4 [doi]
LID - 70
AB  - Accumulating evidence have suggested that long noncoding RNAs (lncRNAs) are known 
      to regulate diverse tumorigenic processes. Recently, a novel lncRNA LINC01939 was 
      underexpressed and emerged as a tumor suppressive lncRNA in gastric cancer (GC). 
      In this study, we aimed to investigate the biological function and molecular 
      mechanism of LINC01939 in GC. We found that LINC01939 expression was 
      significantly downregulated in GC tissues and cell lines. Low expression of 
      LINC01939 was correlated with tumor metastasis and shorter survival in GC 
      patients. Functionally, LINC01939 overexpression remarkably inhibited the 
      invasion and migration of GC cells in vitro and in vivo. Mechanistically, 
      LINC01939 regulated the expression of early growth response 2 (EGR2) protein by 
      competitively binding to miR-17-5p. Upregulation of miR-17-5p reversed GC 
      metastasis and EMT process caused by LINC01939 by rescue analysis. Taken 
      together, these results suggested that LINC01939 repressed GC invasion and 
      migration by functioning as a ceRNA for miR-17-5p to regulate EGR2 expression. 
      Our findings provided a novel prognostic marker and therapeutic target for GC 
      patients.
FAU - Chen, Mi
AU  - Chen M
AD  - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, 430022, China.
FAU - Fan, Li
AU  - Fan L
AD  - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, 430022, China.
FAU - Zhang, Si-Min
AU  - Zhang SM
AD  - Department of Emergency, Wuhan Children's Hospital (Wuhan Maternal and Child 
      Healthcare Hospital), Tongji Medical College, Huazhong University of Science and 
      Technology, Wuhan, 430022, China.
FAU - Li, Yong
AU  - Li Y
AUID- ORCID: 0000-0001-8265-577X
AD  - Department of Oncology, Renmin Hospital, Hubei University of Medicine, Shiyan, 
      442000, China.
FAU - Chen, Peng
AU  - Chen P
AD  - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, 430022, China.
FAU - Peng, Xin
AU  - Peng X
AD  - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, 430022, China.
FAU - Liu, Dong-Bo
AU  - Liu DB
AD  - Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, 430030, China.
FAU - Ma, Charlie
AU  - Ma C
AUID- ORCID: 0000-0002-5341-4827
AD  - Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, 
      19111, USA.
FAU - Zhang, Wen-Jie
AU  - Zhang WJ
AD  - Department of Pathology, Shihezi University School of Medicine, Shihezi, 
      Xinjiang, 832002, China.
FAU - Zou, Zhen-Wei
AU  - Zou ZW
AD  - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, 430022, China. zouzhenwei1983@126.com.
FAU - Li, Pin-Dong
AU  - Li PD
AD  - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, 430022, China. 2012xh0898@hust.edu.cn.
LA  - eng
GR  - P30 CA006927/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190125
PL  - England
TA  - Cell Death Dis
JT  - Cell death & disease
JID - 101524092
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (EGR2 protein, human)
RN  - 0 (Early Growth Response Protein 2)
RN  - 0 (MIRN17 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Animals
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Early Growth Response Protein 2/*metabolism
MH  - Epithelial-Mesenchymal Transition/genetics
MH  - Female
MH  - HEK293 Cells
MH  - Heterografts
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - MicroRNAs/*metabolism
MH  - Middle Aged
MH  - Neoplasm Invasiveness/genetics
MH  - Neoplasm Metastasis/genetics
MH  - Prognosis
MH  - Progression-Free Survival
MH  - RNA, Long Noncoding/*genetics/*metabolism
MH  - Stomach Neoplasms/*metabolism/pathology
MH  - Transfection
PMC - PMC6347617
COIS- The authors declare that they have no conflict of interest.
EDAT- 2019/01/27 06:00
MHDA- 2020/04/09 06:00
PMCR- 2019/01/25
CRDT- 2019/01/27 06:00
PHST- 2018/09/09 00:00 [received]
PHST- 2019/01/04 00:00 [accepted]
PHST- 2018/12/17 00:00 [revised]
PHST- 2019/01/27 06:00 [entrez]
PHST- 2019/01/27 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
PHST- 2019/01/25 00:00 [pmc-release]
AID - 10.1038/s41419-019-1344-4 [pii]
AID - 1344 [pii]
AID - 10.1038/s41419-019-1344-4 [doi]
PST - epublish
SO  - Cell Death Dis. 2019 Jan 25;10(2):70. doi: 10.1038/s41419-019-1344-4.