PMID- 30684774
OWN - NLM
STAT- MEDLINE
DCOM- 20190320
LR  - 20190320
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 221
DP  - 2019 Apr
TI  - Sex-specific alterations of lipid metabolism in zebrafish exposed to 
      polychlorinated biphenyls.
PG  - 768-777
LID - S0045-6535(19)30101-8 [pii]
LID - 10.1016/j.chemosphere.2019.01.094 [doi]
AB  - Polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) 
      mixtures exerting environmental health risk. In mammals, PCBs have been shown to 
      disrupt metabolic state, especially lipid metabolism, and energy balance, but 
      their effects on lipid metabolism in fish are largely unknown. The zebrafish were 
      selected as model and both male and female adult zebrafish were exposed to 
      different concentrations of PCBs at gradient concentrations of 0.2, 2.0 and 
      20.0 mug/L for 6 weeks. PCB exposure did not affect survival, but a significant 
      inhibition of growth was observed in the males after exposure to 20.0 mug/L. The 
      lower concentrations of 0.2 and 2.0 mug/L increased hepatic lipid accumulation to 
      a greater extent in male fish, but the higher concentration of 20.0 mug/L did not 
      cause significant fat accumulation in either male or female fish. In males, the 
      expression of genes related to lipogenesis and lipid catabolism was upregulated 
      in a concentration-dependent manner in the liver and visceral mass without liver 
      and gonad; the effects of exposure on lipid metabolism-related genes in female 
      fish were less pronounced. PCB exposure did not induce significant oxidative 
      stress, but did upregulate the expression of stress- and apoptosis-related genes, 
      mostly in male fish. The low concentrations of PCBs (0.2 mug/L and 2.0 mug/L) 
      exerted sex-specific effects on zebrafish lipid metabolism, and male fish were 
      more sensitive to the exposure. This study provides new mechanistic insights into 
      the complex interactions between PCBs, lipid metabolism, and sex in zebrafish, 
      and may contribute to a future systematic assessment of the effects of PCBs on 
      aquatic ecosystems.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Li, Dong-Liang
AU  - Li DL
AD  - Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of 
      Life Sciences, East China Normal University, Shanghai, PR China.
FAU - Huang, Yu-Juan
AU  - Huang YJ
AD  - Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of 
      Life Sciences, East China Normal University, Shanghai, PR China.
FAU - Gao, Shuang
AU  - Gao S
AD  - Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of 
      Life Sciences, East China Normal University, Shanghai, PR China.
FAU - Chen, Li-Qiao
AU  - Chen LQ
AD  - Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of 
      Life Sciences, East China Normal University, Shanghai, PR China.
FAU - Zhang, Mei-Ling
AU  - Zhang ML
AD  - Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of 
      Life Sciences, East China Normal University, Shanghai, PR China.
FAU - Du, Zhen-Yu
AU  - Du ZY
AD  - Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of 
      Life Sciences, East China Normal University, Shanghai, PR China. Electronic 
      address: zydu@bio.ecnu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190117
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Female
MH  - Gonads/metabolism
MH  - Lipid Metabolism/*drug effects
MH  - Lipogenesis/drug effects
MH  - Liver/metabolism
MH  - Male
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Sex Factors
MH  - Water Pollutants, Chemical/metabolism/toxicity
MH  - Zebrafish/*metabolism
OTO - NOTNLM
OT  - Lipid metabolism
OT  - Polychlorinated biphenyls (PCBs)
OT  - Sex-specific effects
OT  - Zebrafish
EDAT- 2019/01/27 06:00
MHDA- 2019/03/21 06:00
CRDT- 2019/01/27 06:00
PHST- 2018/10/19 00:00 [received]
PHST- 2019/01/11 00:00 [revised]
PHST- 2019/01/15 00:00 [accepted]
PHST- 2019/01/27 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2019/01/27 06:00 [entrez]
AID - S0045-6535(19)30101-8 [pii]
AID - 10.1016/j.chemosphere.2019.01.094 [doi]
PST - ppublish
SO  - Chemosphere. 2019 Apr;221:768-777. doi: 10.1016/j.chemosphere.2019.01.094. Epub 
      2019 Jan 17.