PMID- 30685322
OWN - NLM
STAT- MEDLINE
DCOM- 20190627
LR  - 20190627
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 92
DP  - 2019 Jun 8
TI  - Structural network integrity of the central executive network is associated with 
      the therapeutic effect of rTMS in treatment resistant depression.
PG  - 217-225
LID - S0278-5846(18)30706-1 [pii]
LID - 10.1016/j.pnpbp.2019.01.012 [doi]
AB  - Repetitive transcranial magnetic stimulation (rTMS) is a first-line option for 
      treatment-resistant depression (TRD), but prediction of treatment outcome remains 
      a clinical challenge. The present study aimed to compare structural and 
      functional covariance networks (SCNs and FCNs) between remitters and 
      nonremitters. We determined the predictive capacities of SCNs and FCNs to 
      discriminate the two groups. Fifty TRD patients underwent a course of rTMS to the 
      left dorsolateral prefrontal cortex. They were categorized into remitters 
      (n = 22) and nonremitters (n = 28) based on HDRS</=7 at the end of treatment. 
      Baseline structural and functional magnetic imaging (sMRI and fMRI) of the 
      patients and 42 healthy controls were collected. SCNs and FCNs were defined based 
      on structural and functional covariance of gray mater volume (GMV) and fractional 
      amplitude of low-frequency fluctuations (fALFF) from sMRI and fMRI, respectively. 
      Structural/functional network integrity of these networks (default mode network 
      [DMN], central executive network [CEN] and salience network [SN]) were compared 
      between the three groups. In patients, associations between SCNs and FCNs with 
      clinical improvements were studied using linear correlation analysis. 
      Receiver-operating characteristic (ROC) analysis was conducted to confirm the 
      utility of the SCNs and FCNs in classifying clinical sub-groups. Nonremitters 
      exhibited lower structural integrity in CEN than remitters and controls. Higher 
      structural integrity of CEN was related to clinical improvement (r = 0.423, 
      p = .002), and structural integrity distinguished remitters and nonremitters with 
      a fairly high accuracy (AUC = 0.71, p = .008). No group differences or 
      correlation with clinical changes were found in FCNs. Results suggest the CEN may 
      play a role mediating clinical improvement in rTMS for depression. Structural 
      covariance networks may be features to consider in prediction of clinical 
      improvement.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Ge, Ruiyang
AU  - Ge R
AD  - Non-Invasive Neurostimulation Therapies (NINET) Laboratory, Department of 
      Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 
      2A1, Canada.
FAU - Downar, Jonathan
AU  - Downar J
AD  - Department of Psychiatry, University of Toronto, Toronto, ON, Canada; MRI-Guided 
      rTMS Clinic, Toronto Western Hospital, University Health Network, Toronto, ON, 
      Canada.
FAU - Blumberger, Daniel M
AU  - Blumberger DM
AD  - Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Temerty 
      Centre for Therapeutic Brain Intervention, Campbell Family Research Institute, 
      Centre for Addiction and Mental Health, Toronto, ON, Canada.
FAU - Daskalakis, Zafiris J
AU  - Daskalakis ZJ
AD  - Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Temerty 
      Centre for Therapeutic Brain Intervention, Campbell Family Research Institute, 
      Centre for Addiction and Mental Health, Toronto, ON, Canada.
FAU - Lam, Raymond W
AU  - Lam RW
AD  - Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, 
      Vancouver, BC V6T 2A1, Canada.
FAU - Vila-Rodriguez, Fidel
AU  - Vila-Rodriguez F
AD  - Non-Invasive Neurostimulation Therapies (NINET) Laboratory, Department of 
      Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 
      2A1, Canada. Electronic address: fidel.vilarodriguez@ubc.ca.
LA  - eng
GR  - Canadian Institutes of Health Research/International
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190125
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
SB  - IM
MH  - Adult
MH  - Brain/diagnostic imaging/*physiopathology
MH  - Cross-Sectional Studies
MH  - Depressive Disorder, Treatment-Resistant/diagnostic 
      imaging/*physiopathology/*therapy
MH  - Executive Function/physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/diagnostic imaging/physiopathology
MH  - Remission Induction
MH  - *Transcranial Magnetic Stimulation
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Central executive network
OT  - Major depressive disorder
OT  - Remission
OT  - Repetitive transcranial magnetic stimulation
OT  - Structural covariance network
EDAT- 2019/01/28 06:00
MHDA- 2019/06/30 06:00
CRDT- 2019/01/28 06:00
PHST- 2018/09/05 00:00 [received]
PHST- 2019/01/12 00:00 [revised]
PHST- 2019/01/23 00:00 [accepted]
PHST- 2019/01/28 06:00 [pubmed]
PHST- 2019/06/30 06:00 [medline]
PHST- 2019/01/28 06:00 [entrez]
AID - S0278-5846(18)30706-1 [pii]
AID - 10.1016/j.pnpbp.2019.01.012 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8;92:217-225. doi: 
      10.1016/j.pnpbp.2019.01.012. Epub 2019 Jan 25.