PMID- 30685611
OWN - NLM
STAT- MEDLINE
DCOM- 20190611
LR  - 20190613
IS  - 1095-7103 (Electronic)
IS  - 0021-9797 (Linking)
VI  - 541
DP  - 2019 Apr 1
TI  - Amino modified metal-organic frameworks as pH-responsive nanoplatforms for safe 
      delivery of camptothecin.
PG  - 163-174
LID - S0021-9797(19)30055-4 [pii]
LID - 10.1016/j.jcis.2019.01.042 [doi]
AB  - MIL-100(Fe) and MIL-101(Fe) metal-organic frameworks (MOFs) are excellent 
      vehicles for drug delivery systems (DDSs) due to their high biocompatibility and 
      stability in physiological fluids, as well as their pore diameter in the 
      mesoporous range. Although they are appropriate for the internal diffusion of 
      20-(S)-camptothecin (CPT), a strongly cytotoxic molecule with excellent antitumor 
      activity, no stable delivery system has been proposed so far for this drug based 
      in MOFs. We here present novel DDSs based in amine functionalized MIL-100(Fe) and 
      MIL-101(Fe) nanoMOFs with covalently bonded CPT. These CPT nanoplatforms are able 
      to incorporate almost 20% of this molecule and show high stability at 
      physiological pH, with no non-specific release. Based on their surface charge, 
      some of these CPT loaded nanoMOFs present improved cell internalization in in 
      vitro experiments. Moreover, a strong response to acid pH is observed, with up to 
      four fold drug discharge at pH 5, which boost intracellular release by 
      endosomolytic activity. These novel DDSs will help to achieve safe delivery of 
      the very cytotoxic CPT, allowing to reduce the therapeutic dose and minimizing 
      drug secondary effects.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Cabrera-Garcia, Alejandro
AU  - Cabrera-Garcia A
AD  - Instituto de Tecnologia Quimica, Universitat Politecnica de Valencia-Consejo 
      Superior de Investigaciones Cientificas, Avenida de los Naranjos s/n, 46022 
      Valencia, Spain.
FAU - Checa-Chavarria, Elisa
AU  - Checa-Chavarria E
AD  - Institute of Bioengineering, Universidad Miguel Hernandez Elche, Spain and Centre 
      for Network Biomedical Research (CIBER-BBN), Spain.
FAU - Rivero-Buceta, Eva
AU  - Rivero-Buceta E
AD  - Instituto de Tecnologia Quimica, Universitat Politecnica de Valencia-Consejo 
      Superior de Investigaciones Cientificas, Avenida de los Naranjos s/n, 46022 
      Valencia, Spain.
FAU - Moreno, Victoria
AU  - Moreno V
AD  - Neuronal and Tissue Regeneration Lab, Research Centre "Principe Felipe", 
      Valencia, Spain.
FAU - Fernandez, Eduardo
AU  - Fernandez E
AD  - Institute of Bioengineering, Universidad Miguel Hernandez Elche, Spain and Centre 
      for Network Biomedical Research (CIBER-BBN), Spain.
FAU - Botella, Pablo
AU  - Botella P
AD  - Instituto de Tecnologia Quimica, Universitat Politecnica de Valencia-Consejo 
      Superior de Investigaciones Cientificas, Avenida de los Naranjos s/n, 46022 
      Valencia, Spain. Electronic address: pbotella@itq.upv.es.
LA  - eng
PT  - Journal Article
DEP - 20190117
PL  - United States
TA  - J Colloid Interface Sci
JT  - Journal of colloid and interface science
JID - 0043125
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Metal-Organic Frameworks)
RN  - XT3Z54Z28A (Camptothecin)
SB  - IM
MH  - Antineoplastic Agents, Phytogenic/*administration & dosage/chemistry
MH  - Camptothecin/*administration & dosage/chemistry
MH  - *Cell Survival
MH  - Cells, Cultured
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Fibroblasts/cytology/drug effects
MH  - HeLa Cells
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Metal Nanoparticles/*administration & dosage/chemistry
MH  - Metal-Organic Frameworks/*chemistry
MH  - Neuroblastoma/drug therapy/pathology
OTO - NOTNLM
OT  - Biodegradability
OT  - Camptothecin
OT  - Drug delivery
OT  - Metal-organic frameworks
OT  - pH-responsive
EDAT- 2019/01/28 06:00
MHDA- 2019/06/14 06:00
CRDT- 2019/01/28 06:00
PHST- 2018/10/08 00:00 [received]
PHST- 2019/01/07 00:00 [revised]
PHST- 2019/01/11 00:00 [accepted]
PHST- 2019/01/28 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/01/28 06:00 [entrez]
AID - S0021-9797(19)30055-4 [pii]
AID - 10.1016/j.jcis.2019.01.042 [doi]
PST - ppublish
SO  - J Colloid Interface Sci. 2019 Apr 1;541:163-174. doi: 10.1016/j.jcis.2019.01.042. 
      Epub 2019 Jan 17.