PMID- 3068597
OWN - NLM
STAT- MEDLINE
DCOM- 19890417
LR  - 20180217
IS  - 0030-3755 (Print)
IS  - 0030-3755 (Linking)
VI  - 197
IP  - 4
DP  - 1988
TI  - Clinical application of epiderm growth factor in patients with most severe eye 
      burns.
PG  - 179-84
AB  - 20 eyes of 11 patients suffering from most severe eye burns of grade 4 or worse 
      were treated in addition to various other drugs with epiderm growth factor (EGF) 
      or placebo in a double-blind test. Among 10 eyes treated with EGF, 6 achieved 
      complete regeneration of the corneal epithelium, and 1 additional case, of the 
      conjunctival epithelium. Among the eyes receiving placebo, only 3 out of 10 
      healed; all of them were also treated with fibronectin. Although in these very 
      difficult cases EGF could not be investigated as a single therapy, and various 
      other undefined factors may have been effective, in the extended course of the 
      disease the period of EGF treatment was marked by a significant better 
      regeneration of the epithelium.
FAU - Reim, M
AU  - Reim M
AD  - Abteilung Augenheikunde, Medizinische Fakultat, Rheinisch-Westfalische Technische 
      Hochschule Aachen.
FAU - Kehrer, T
AU  - Kehrer T
FAU - Lund, M
AU  - Lund M
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Ophthalmologica
JT  - Ophthalmologica. Journal international d'ophtalmologie. International journal of 
      ophthalmology. Zeitschrift fur Augenheilkunde
JID - 0054655
RN  - 0 (Fibronectins)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Burns, Chemical/drug therapy
MH  - Clinical Trials as Topic
MH  - Double-Blind Method
MH  - Epidermal Growth Factor/*therapeutic use
MH  - Eye Burns/*drug therapy
MH  - Fibronectins/therapeutic use
MH  - Humans
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1159/000309941 [doi]
PST - ppublish
SO  - Ophthalmologica. 1988;197(4):179-84. doi: 10.1159/000309941.