PMID- 30687140
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 9
DP  - 2018
TI  - The Effect of Insomnia on Cortical Excitability in Patients With Generalized 
      Anxiety Disorder.
PG  - 755
LID - 10.3389/fpsyt.2018.00755 [doi]
LID - 755
AB  - The high rate of comorbidity between insomnia and anxiety disorders have been 
      confirmed by previous studies. However, the underlying neurobiological correlates 
      of the relationship between insomnia and anxiety disorders are largely unknown. 
      The aim of the present study was to investigate the effect of insomnia on 
      cortical excitability in patients with generalized anxiety disorder (GAD) by 
      examining the recovery functions of median nerve somatosensory evoked potentials 
      (SEPs) in patients with GAD without insomnia and patients with GAD comorbid with 
      insomnia. We studied the recovery functions of median nerve SEPs in 12 
      medication-naive patients with GAD without insomnia, 15 medication-naive patients 
      with GAD comorbid with insomnia, and 15 age and sex matched healthy controls. 
      SEPs in response to single stimulus and paired stimuli at interstimulus intervals 
      (ISIs) of 20, 60, 100, and 150 ms were recorded. The recovery function of the P25 
      component showed significantly reduced suppression in patients with GAD without 
      insomnia as compared to patients with GAD comorbid with insomnia and healthy 
      controls. There were no significant differences in the recovery functions of 
      median nerve SEPs between patients with GAD comorbid with insomnia and healthy 
      controls. The present study suggested that the cortical excitability of right 
      parietal cortex increased in patients with GAD without insomnia, and cortical 
      excitability in patients with GAD comorbid with insomnia was modulated by 
      insomnia. Our findings provide new insights into the underlying neurobiological 
      correlates of the effects of insomnia on GAD, which could ultimately be used to 
      inform clinical intervention.
FAU - Huang, Zhaoyang
AU  - Huang Z
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
FAU - Zhan, Shuqin
AU  - Zhan S
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
FAU - Chen, Chao
AU  - Chen C
AD  - Key Laboratory of Complex System Control Theory and Application, Tianjin 
      University of Technology, Tianjin, China.
FAU - Li, Ning
AU  - Li N
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
FAU - Ding, Yan
AU  - Ding Y
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
FAU - Hou, Yue
AU  - Hou Y
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
FAU - Wang, Li
AU  - Wang L
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
FAU - Wang, Yuping
AU  - Wang Y
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
LA  - eng
GR  - K99 AA020514/AA/NIAAA NIH HHS/United States
GR  - R00 AA020514/AA/NIAAA NIH HHS/United States
PT  - Journal Article
DEP - 20190110
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC6335338
OTO - NOTNLM
OT  - generalized anxiety disorder
OT  - insomnia
OT  - recovery function
OT  - right parietal cortex
OT  - somatosensory evoked potential
EDAT- 2019/01/29 06:00
MHDA- 2019/01/29 06:01
PMCR- 2019/01/10
CRDT- 2019/01/29 06:00
PHST- 2018/09/15 00:00 [received]
PHST- 2018/12/20 00:00 [accepted]
PHST- 2019/01/29 06:00 [entrez]
PHST- 2019/01/29 06:00 [pubmed]
PHST- 2019/01/29 06:01 [medline]
PHST- 2019/01/10 00:00 [pmc-release]
AID - 10.3389/fpsyt.2018.00755 [doi]
PST - epublish
SO  - Front Psychiatry. 2019 Jan 10;9:755. doi: 10.3389/fpsyt.2018.00755. eCollection 
      2018.