PMID- 30687326
OWN - NLM
STAT- MEDLINE
DCOM- 20191025
LR  - 20200309
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 9
DP  - 2018
TI  - Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to 
      Enhance Vaccine Effectiveness?
PG  - 3123
LID - 10.3389/fimmu.2018.03123 [doi]
LID - 3123
AB  - Increased susceptibility to infectious diseases is a hallmark of the neonatal 
      period of life that is generally attributed to a relative immaturity of the 
      immune system. Dendritic cells (DCs) are innate immune sentinels with vital roles 
      in the initiation and orchestration of immune responses, thus, constituting a 
      promising target for promoting neonatal immunity. However, as is the case for 
      other immune cells, neonatal DCs have been suggested to be functionally immature 
      compared to their adult counterparts. Here we review some of the unique aspects 
      of neonatal DCs that shape immune responses in early life and speculate whether 
      the functional properties of neonatal DCs could be exploited or manipulated to 
      promote more effective vaccination in early life.
FAU - Papaioannou, Nikos E
AU  - Papaioannou NE
AD  - Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, 
      Ludwig-Maximilians-University Munich, Munich, Germany.
FAU - Pasztoi, Maria
AU  - Pasztoi M
AD  - Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, 
      Ludwig-Maximilians-University Munich, Munich, Germany.
FAU - Schraml, Barbara U
AU  - Schraml BU
AD  - Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, 
      Ludwig-Maximilians-University Munich, Munich, Germany.
AD  - Walter-Brendel-Centre of Experimental Medicine, University Hospital, 
      Ludwig-Maximilians-University Munich, Munich, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190110
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Vaccines)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Bacterial Infections/immunology/microbiology/prevention & control
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunogenicity, Vaccine
MH  - Infant, Newborn
MH  - Mice
MH  - Vaccination/*methods
MH  - Vaccines/administration & dosage/*immunology
MH  - Virus Diseases/immunology/microbiology/prevention & control
PMC - PMC6335269
OTO - NOTNLM
OT  - DC subsets
OT  - DC targeting
OT  - T cell activation
OT  - dendritic cell (DC)
OT  - early life immunity
OT  - immune system development
OT  - innate immunity
OT  - vaccination
EDAT- 2019/01/29 06:00
MHDA- 2019/10/28 06:00
PMCR- 2018/01/01
CRDT- 2019/01/29 06:00
PHST- 2018/08/29 00:00 [received]
PHST- 2018/12/18 00:00 [accepted]
PHST- 2019/01/29 06:00 [entrez]
PHST- 2019/01/29 06:00 [pubmed]
PHST- 2019/10/28 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2018.03123 [doi]
PST - epublish
SO  - Front Immunol. 2019 Jan 10;9:3123. doi: 10.3389/fimmu.2018.03123. eCollection 
      2018.