PMID- 30687553
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2090-2085 (Print)
IS  - 2090-2093 (Electronic)
IS  - 2090-2093 (Linking)
VI  - 2018
DP  - 2018
TI  - Assessing the Relationship between Performance on the University of California 
      Performance Skills Assessment (UPSA) and Outcomes in Schizophrenia: A Systematic 
      Review and Evidence Synthesis.
PG  - 9075174
LID - 10.1155/2018/9075174 [doi]
LID - 9075174
AB  - OBJECTIVE: To perform a systematic review of the published literature to evaluate 
      how functional capacity, as measured by the University of California at San Diego 
      (UCSD) Performance-based Skills Assessment (UPSA), relates to other functional 
      measures and real-world outcomes among individuals with schizophrenia. METHODS: 
      The MEDLINE(R) and Embase(R) databases were searched to identify joint evaluations 
      with UPSA and key functional outcomes (functional scale measures; generic or 
      disease-specific, health-related quality of life [HRQoL]; or real-world outcomes 
      [residential status; employment status]) in patients with schizophrenia. Pearson 
      correlations were estimated between UPSA scores, HRQoL, other functional scale 
      measures, and real-world outcomes, for outcomes described in at least six 
      studies. RESULTS: The synthesis included 76 studies that provided 73 unique data 
      sets. Quantitative assessment between the Specific Level of Function (SLOF) 
      (n=18) scores and UPSA scores demonstrated a moderate borderline-significant 
      correlation (0.45, p=0.06). Quantitative analysis of the relationship between the 
      Global Assessment of Functioning (GAF) (n=11) and the Multidimensional Scale of 
      Independent Functioning (MSIF) (n=6) scales revealed moderate and small 
      nonsignificant Pearson correlations of -0.34 (p=0.31) and 0.12 (p=0.83), 
      respectively. There was a small borderline-significant correlation between UPSA 
      score and residential status (n=36; 0.31; p=0.08), while no correlation was found 
      between UPSA score and employment status (n=19; 0.04; p=0.88). CONCLUSION: The 
      SLOF was the most often used functional measure and had the strongest observed 
      correlation with the UPSA. Although knowledge gaps remain, evidence from this 
      review indicates that there is a quantitative relationship between functional 
      capacity and real-world outcomes in individuals with schizophrenia.
FAU - Szabo, Shelagh
AU  - Szabo S
AUID- ORCID: 0000-0002-9044-3192
AD  - Broadstreet HEOR, Vancouver, BC, Canada.
FAU - Merikle, Elizabeth
AU  - Merikle E
AUID- ORCID: 0000-0002-3310-1196
AD  - Takeda Pharmaceuticals, Deerfield, IL, USA.
FAU - Lozano-Ortega, Greta
AU  - Lozano-Ortega G
AUID- ORCID: 0000-0002-5378-0544
AD  - Broadstreet HEOR, Vancouver, BC, Canada.
FAU - Powell, Lauren
AU  - Powell L
AD  - Broadstreet HEOR, Vancouver, BC, Canada.
FAU - Macek, Thomas
AU  - Macek T
AD  - Takeda Pharmaceuticals, Deerfield, IL, USA.
FAU - Cline, Stephanie
AU  - Cline S
AUID- ORCID: 0000-0002-9157-7782
AD  - Takeda Pharmaceuticals, Deerfield, IL, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181227
PL  - Egypt
TA  - Schizophr Res Treatment
JT  - Schizophrenia research and treatment
JID - 101576450
PMC - PMC6327277
EDAT- 2019/01/29 06:00
MHDA- 2019/01/29 06:01
PMCR- 2018/12/27
CRDT- 2019/01/29 06:00
PHST- 2018/05/24 00:00 [received]
PHST- 2018/11/12 00:00 [revised]
PHST- 2018/12/05 00:00 [accepted]
PHST- 2019/01/29 06:00 [entrez]
PHST- 2019/01/29 06:00 [pubmed]
PHST- 2019/01/29 06:01 [medline]
PHST- 2018/12/27 00:00 [pmc-release]
AID - 10.1155/2018/9075174 [doi]
PST - epublish
SO  - Schizophr Res Treatment. 2018 Dec 27;2018:9075174. doi: 10.1155/2018/9075174. 
      eCollection 2018.