PMID- 30689334
OWN - NLM
STAT- MEDLINE
DCOM- 20190617
LR  - 20190617
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 11
IP  - 7
DP  - 2019 Feb 20
TI  - Mussel-Inspired Polydopamine Coating: A General Strategy To Enhance Osteogenic 
      Differentiation and Osseointegration for Diverse Implants.
PG  - 7615-7625
LID - 10.1021/acsami.8b21558 [doi]
AB  - Surface modifications play an important role in endowing implant surface with 
      excellent biocompatibility and bioactivity. Among the bioinspired surface 
      modifications, the mussel-inspired polydopamine (PDA) has aroused great interest 
      of researchers. Herein, we fabricated PDA on diverse implant surfaces, including 
      biopolymer, biometal, and bioceramic. Then the effects of PDA coating on cell 
      responsive behaviors in vitro and bone formation capacity in vivo were evaluated 
      in detail. The results showed that PDA coating was fabricated on diverse samples 
      surface successfully, which could significantly improve the hydrophilicity of 
      different material surfaces. Furthermore, the results indicated that PDA coating 
      exerted direct enhancing on the adhesion, proliferation and osteogenic 
      differentiation of bone marrow derived mesenchymal stromal cells (BMSCs) through 
      FAK and p38 signaling pathways. During the process, the focal adhesion protein 
      expression and osteogenic-related genes expression level (e.g., ALP, BMP2, BSP, 
      and OPN) were considerably upregulated. Most importantly, the in vivo study 
      confirmed that PDA coating remarkably accelerated new bone formation and enhanced 
      osseointegration performance. Our study uncovered the biological responses 
      stimulated by PDA coating to make a better understanding of cell/tissue-PDA 
      interactions and affirmed that PDA, a bioinspired polymer, has great potential as 
      a candidate and functional bioactive coating medium in bone regeneration and 
      orthopedic application.
FAU - Wang, Hui
AU  - Wang H
AD  - School and Hospital of Stomatology and Shanghai Engineering Research Center of 
      Tooth Restoration and Regeneration , Tongji University , Shanghai 200072 , China.
FAU - Lin, Chucheng
AU  - Lin C
AD  - Shanghai Institute of Ceramics , Chinese Academy of Sciences , Shanghai 200050 , 
      China.
FAU - Zhang, Xinran
AU  - Zhang X
AD  - School and Hospital of Stomatology and Shanghai Engineering Research Center of 
      Tooth Restoration and Regeneration , Tongji University , Shanghai 200072 , China.
FAU - Lin, Kaili
AU  - Lin K
AUID- ORCID: 0000-0002-1900-9641
FAU - Wang, Xudong
AU  - Wang X
FAU - Shen, Steve Guofang
AU  - Shen SG
LA  - eng
PT  - Journal Article
DEP - 20190208
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Indoles)
RN  - 0 (Polymers)
RN  - 0 (polydopamine)
SB  - IM
MH  - Animals
MH  - *Bivalvia
MH  - Cell Adhesion/drug effects
MH  - Cell Differentiation/drug effects
MH  - Cell Proliferation/drug effects
MH  - *Coated Materials, Biocompatible/chemistry/pharmacology
MH  - Gene Expression Regulation/drug effects
MH  - *Implants, Experimental
MH  - *Indoles/chemistry/pharmacology
MH  - Male
MH  - Mesenchymal Stem Cells/metabolism/pathology
MH  - Osseointegration/*drug effects
MH  - Osteogenesis/*drug effects
MH  - *Polymers/chemistry/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - cell signaling pathway
OT  - coating
OT  - osseointegration
OT  - osteogenic differentiation
OT  - polydopamine
EDAT- 2019/01/29 06:00
MHDA- 2019/06/18 06:00
CRDT- 2019/01/29 06:00
PHST- 2019/01/29 06:00 [pubmed]
PHST- 2019/06/18 06:00 [medline]
PHST- 2019/01/29 06:00 [entrez]
AID - 10.1021/acsami.8b21558 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2019 Feb 20;11(7):7615-7625. doi: 
      10.1021/acsami.8b21558. Epub 2019 Feb 8.