PMID- 30689576
OWN - NLM
STAT- MEDLINE
DCOM- 20200527
LR  - 20200527
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 67
IP  - 4
DP  - 2019
TI  - KIR2DS2/KIR2DL2/HLA-C1 Haplotype Is Associated with Alzheimer's Disease: 
      Implication for the Role of Herpesvirus Infections.
PG  - 1379-1389
LID - 10.3233/JAD-180777 [doi]
AB  - Alzheimer's disease (AD) is a progressive neurodegenerative disorder, where 
      neuroinflammation and immune cells are key pathological factors. Recently, it was 
      suggested a possible association between AD and human herpesvirus 6 (HHV-6) 
      infection. Since we recently observed that multiple sclerosis patients with 
      KIR2DL2 expression on natural killer (NK) cells are more susceptible to 
      herpesvirus infection, we tested the possible implication of KIR/HLA genetic for 
      HHV-6A infection. We identified, for the first time, a possible implication of a 
      specific KIR/HLA subset in AD. The combination KIR2DS2/KIR2DL2/C1 correlated with 
      a lower MMSEDi score, representative of a severe AD status and an increased 
      susceptibility to HHV-6A infection. Therefore, the results seem to converge on 
      the hypothesis that herpesvirus infection might play a role in AD. If this 
      hypothesis finds experimental confirmation, a new therapeutic strategy, 
      modulating KIR2DL2 expression on NK cells, for AD might be envisaged.
FAU - Rizzo, Roberta
AU  - Rizzo R
AD  - Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
FAU - Bortolotti, Daria
AU  - Bortolotti D
AD  - Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
FAU - Gentili, Valentina
AU  - Gentili V
AD  - Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
FAU - Rotola, Antonella
AU  - Rotola A
AD  - Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
FAU - Bolzani, Silvia
AU  - Bolzani S
AD  - Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
FAU - Caselli, Elisabetta
AU  - Caselli E
AD  - Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
FAU - Tola, Maria Rosaria
AU  - Tola MR
AD  - Department of Neurosciences and Rehabilitation, University Hospital, Arcispedale 
      S. Anna, Ferrara, Italy.
FAU - Di Luca, Dario
AU  - Di Luca D
AD  - Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Apolipoproteins E)
RN  - 0 (KIR2DL2 protein, human)
RN  - 0 (KIR2DS2 protein, human)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR2DL2)
SB  - IM
MH  - Aged
MH  - *Alzheimer Disease/diagnosis/genetics/virology
MH  - Apolipoproteins E/genetics
MH  - Female
MH  - Gene Expression
MH  - Gene Expression Profiling/methods
MH  - Haplotypes/*genetics
MH  - *Herpesviridae Infections/genetics/virology
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - Killer Cells, Natural/metabolism
MH  - Male
MH  - Mental Status and Dementia Tests
MH  - Receptors, KIR/*genetics
MH  - Receptors, KIR2DL2/*genetics
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - HHV-6A
OT  - KIR
OT  - NK cell
OT  - herpesvirus
EDAT- 2019/01/29 06:00
MHDA- 2020/05/28 06:00
CRDT- 2019/01/29 06:00
PHST- 2019/01/29 06:00 [pubmed]
PHST- 2020/05/28 06:00 [medline]
PHST- 2019/01/29 06:00 [entrez]
AID - JAD180777 [pii]
AID - 10.3233/JAD-180777 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2019;67(4):1379-1389. doi: 10.3233/JAD-180777.