PMID- 30691120
OWN - NLM
STAT- MEDLINE
DCOM- 20190404
LR  - 20200225
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 11
IP  - 2
DP  - 2019 Jan 26
TI  - UP1306: A Composition Containing Standardized Extracts of Acacia catechu and 
      Morus alba for Arthritis Management.
LID - 10.3390/nu11020272 [doi]
LID - 272
AB  - Osteoarthritis (OA) is characterized by progressive articular cartilage 
      degradation. Although there have been significant advances in OA management, to 
      date, there are no effective treatment options to modify progression of the 
      disease. We believe these unmet needs could be bridged by nutrients from natural 
      products. Collagen induced arthritis in rats was developed and utilized to 
      evaluate anti-inflammatory and cartilage protection activity of orally 
      administered botanical composition, UP1306 (50 mg/kg) and Methotrexate (75 microg/kg) 
      daily for three weeks. Objective arthritis severity markers, urine, synovial 
      lavage, and serum were collected. At necropsy, the hock joint from each rat was 
      collected for histopathology analysis. Urinary cartilage degradation marker 
      (CTX-II), pro-inflammatory cytokines (tumor necrosis factor alpha (TNF-alpha), 
      interleukin-1beta (IL-1beta), and IL-6), and proteases (Matrix Metallopeptidase 3 
      (MMP3) and 13) were measured. Rats treated with UP1306 showed statistically 
      significant improvements in arthritis severity markers, including uCTX-II (91.4% 
      vs. collagen-induced arthritis (CIA)), serum IL-1beta, TNF-alpha, and IL-6 levels as 
      well as synovial MMP-13. The histopathology data were also well aligned with the 
      severity score of arthritis for both UP1306 and Methotrexate. UP1306, a botanical 
      composition that contains a standardized blend of extracts from the heartwood of 
      Acacia catechu and the root bark of Morus alba, could potentially be considered 
      as a dietary supplement product for the management of arthritis.
FAU - Yimam, Mesfin
AU  - Yimam M
AD  - Unigen Inc., 2121 South State Street, Suite 400, Tacoma, WA 98405, USA. 
      myimam@unigen.net.
FAU - Horm, Teresa
AU  - Horm T
AD  - Unigen Inc., 2121 South State Street, Suite 400, Tacoma, WA 98405, USA. 
      thorm@unigen.net.
FAU - Wright, Laura
AU  - Wright L
AD  - Fred Hutch Cancer Research, 1100 Fairview Ave N, Seattle, WA 98109, USA. 
      lwright@fredhutch.org.
FAU - Jiao, Ping
AU  - Jiao P
AD  - Unigen Inc., 2121 South State Street, Suite 400, Tacoma, WA 98405, USA. 
      pjiao@unigen.net.
FAU - Hong, Mei
AU  - Hong M
AD  - Unigen Inc., 2121 South State Street, Suite 400, Tacoma, WA 98405, USA. 
      meih@unigen.net.
FAU - Brownell, Lidia
AU  - Brownell L
AD  - Unigen Inc., 2121 South State Street, Suite 400, Tacoma, WA 98405, USA. 
      lbrownell@unigen.net.
FAU - Jia, Qi
AU  - Jia Q
AD  - Unigen Inc., 2121 South State Street, Suite 400, Tacoma, WA 98405, USA. 
      qjia@unigen.net.
LA  - eng
PT  - Journal Article
DEP - 20190126
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Acacia/*chemistry
MH  - Animals
MH  - Arthritis, Experimental/*drug therapy/pathology
MH  - Cytokines/metabolism
MH  - Male
MH  - Morus/*chemistry
MH  - *Plant Extracts/chemistry/pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Severity of Illness Index
MH  - Tarsal Joints/chemistry/drug effects/pathology
PMC - PMC6413154
OTO - NOTNLM
OT  - Acacia catechu
OT  - Morus alba
OT  - UP1306
OT  - collagen induced arthritis
COIS- Except Laura Wright, all authors are current Unigen employees, therefore they 
      have competing financial interests.
EDAT- 2019/01/30 06:00
MHDA- 2019/04/05 06:00
PMCR- 2019/02/01
CRDT- 2019/01/30 06:00
PHST- 2018/12/20 00:00 [received]
PHST- 2019/01/23 00:00 [revised]
PHST- 2019/01/23 00:00 [accepted]
PHST- 2019/01/30 06:00 [entrez]
PHST- 2019/01/30 06:00 [pubmed]
PHST- 2019/04/05 06:00 [medline]
PHST- 2019/02/01 00:00 [pmc-release]
AID - nu11020272 [pii]
AID - nutrients-11-00272 [pii]
AID - 10.3390/nu11020272 [doi]
PST - epublish
SO  - Nutrients. 2019 Jan 26;11(2):272. doi: 10.3390/nu11020272.