PMID- 30692038
OWN - NLM
STAT- MEDLINE
DCOM- 20200420
LR  - 20231215
IS  - 2213-2317 (Electronic)
IS  - 2213-2317 (Linking)
VI  - 23
DP  - 2019 May
TI  - NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis.
PG  - 101107
LID - S2213-2317(18)31026-7 [pii]
LID - 10.1016/j.redox.2019.101107 [doi]
LID - 101107
AB  - The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a 
      key regulator of the cellular antioxidant response, controlling the expression of 
      genes that counteract oxidative and electrophilic stresses. Many pathological 
      conditions are linked to imbalances in redox homeostasis, illustrating the 
      important role of antioxidant defense systems in preventing the pathogenic 
      effects associated with the accumulation of reactive species. In particular, it 
      is becoming increasingly apparent that the accumulation of lipid peroxides has an 
      important role in driving the pathogenesis of multiple disease states. A key 
      example of this is the recent discovery of a novel form of cell death termed 
      ferroptosis. Ferroptosis is an iron-dependent, lipid peroxidation-driven cell 
      death cascade that has become a key target in the development of anti-cancer 
      therapies, as well as the prevention of neurodegenerative and cardiovascular 
      diseases. In this review, we will provide a brief overview of lipid peroxidation, 
      as well as key components involved in the ferroptotic cascade. We will also 
      highlight the role of the NRF2 signaling pathway in mediating lipid peroxidation 
      and ferroptosis, focusing on established NRF2 target genes that mitigate these 
      pathways, as well as the relevance of the NRF2-lipid peroxidation-ferroptosis 
      axis in disease.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Dodson, Matthew
AU  - Dodson M
AD  - Department of Pharmacology and Toxicology, College of Pharmacy, University of 
      Arizona, Tucson, AZ, USA, 85721.
FAU - Castro-Portuguez, Raul
AU  - Castro-Portuguez R
AD  - Department of Pharmacology and Toxicology, College of Pharmacy, University of 
      Arizona, Tucson, AZ, USA, 85721.
FAU - Zhang, Donna D
AU  - Zhang DD
AD  - Department of Pharmacology and Toxicology, College of Pharmacy, University of 
      Arizona, Tucson, AZ, USA, 85721; Arizona Cancer Center, University of Arizona, 
      Tucson, AZ, USA, 85724. Electronic address: dzhang@pharmacy.arizona.edu.
LA  - eng
GR  - P42 ES004940/ES/NIEHS NIH HHS/United States
GR  - P30 ES006694/ES/NIEHS NIH HHS/United States
GR  - R35 ES031575/ES/NIEHS NIH HHS/United States
GR  - R01 DK109555/DK/NIDDK NIH HHS/United States
GR  - R01 ES026845/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20190111
PL  - Netherlands
TA  - Redox Biol
JT  - Redox biology
JID - 101605639
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Animals
MH  - Cell Death
MH  - *Ferroptosis
MH  - Humans
MH  - *Lipid Metabolism
MH  - *Lipid Peroxidation
MH  - NF-E2-Related Factor 2/*metabolism
MH  - Neoplasms/etiology/metabolism/pathology
MH  - Oxidation-Reduction
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction
PMC - PMC6859567
EDAT- 2019/01/30 06:00
MHDA- 2020/04/21 06:00
PMCR- 2019/01/11
CRDT- 2019/01/30 06:00
PHST- 2018/11/01 00:00 [received]
PHST- 2018/12/13 00:00 [revised]
PHST- 2019/01/10 00:00 [accepted]
PHST- 2019/01/30 06:00 [pubmed]
PHST- 2020/04/21 06:00 [medline]
PHST- 2019/01/30 06:00 [entrez]
PHST- 2019/01/11 00:00 [pmc-release]
AID - S2213-2317(18)31026-7 [pii]
AID - 101107 [pii]
AID - 10.1016/j.redox.2019.101107 [doi]
PST - ppublish
SO  - Redox Biol. 2019 May;23:101107. doi: 10.1016/j.redox.2019.101107. Epub 2019 Jan 
      11.