PMID- 30692756
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 0972-2327 (Print)
IS  - 1998-3549 (Electronic)
IS  - 0972-2327 (Linking)
VI  - 22
IP  - 1
DP  - 2019 Jan-Mar
TI  - Newer Antiepileptic Drugs Discontinuation due to Adverse Effects: An 
      Observational Study.
PG  - 27-30
LID - 10.4103/aian.AIAN_25_18 [doi]
AB  - AIMS: Antiepileptic drugs are the main therapy for epilepsy. However, the 
      incidence of adverse effects (AEs) results in treatment discontinuation. The aim 
      of this study is evaluating the factors involved in discontinuation of 
      antiepileptic drugs. SETTINGS AND DESIGN: We studied 2797 epileptic patients who 
      consumed levetiracetam (LEV), oxcarbazepine (OXC), topiramate (TPM), zonisamide 
      (ZNS), rufinamide, and lacosamide to evaluate the discontinuation because of AEs. 
      STATISTICAL ANALYSIS USED: Data were analyzed using descriptive statistics and 
      Chi-square test. RESULTS: This study showed the rate of discontinuation due to 
      adverse reactions as follows: TPM (7.10%), OXC (4.5%), ZNS (1.8%), and LEV (1.6%) 
      (Chi-square analysis, P < 0.0001). Our study also showed that 1.35% of the 
      patients did not continue the therapy because of subjective experiences of the 
      AEs. Furthermore, neurologic complications in TPM, skin rashes in OXC, and 
      patients' subjective experiences in LEV prescription were the main reasons for 
      nonadherence due to a AEs. CONCLUSIONS: AEs in newer antiepileptic drugs are 
      extremely prevalent. Our observation revealed that skin rashes and paresthesia 
      were the most probable causes of treatment discontinuation because of AEs.
FAU - Golpayegani, Mehdi
AU  - Golpayegani M
AD  - Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Salari, Farhad
AU  - Salari F
AD  - Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Gharagozli, Kurosh
AU  - Gharagozli K
AD  - Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Ann Indian Acad Neurol
JT  - Annals of Indian Academy of Neurology
JID - 101273955
PMC - PMC6327699
OTO - NOTNLM
OT  - Adverse effects
OT  - anticonvulsant
OT  - epilepsy
OT  - medication adherence
COIS- There are no conflicts of interest.
EDAT- 2019/01/30 06:00
MHDA- 2019/01/30 06:01
PMCR- 2019/01/01
CRDT- 2019/01/30 06:00
PHST- 2019/01/30 06:00 [entrez]
PHST- 2019/01/30 06:00 [pubmed]
PHST- 2019/01/30 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - AIAN-22-27 [pii]
AID - 10.4103/aian.AIAN_25_18 [doi]
PST - ppublish
SO  - Ann Indian Acad Neurol. 2019 Jan-Mar;22(1):27-30. doi: 10.4103/aian.AIAN_25_18.