PMID- 30692827
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220401
IS  - 1016-3190 (Print)
IS  - 2223-8956 (Electronic)
VI  - 31
IP  - 1
DP  - 2019 Jan-Mar
TI  - Human leukocyte antigen-A*33:03-B*58:01-DRB1*15:140, a deduced probable human 
      leukocyte antigen haplotype in association with a human leukocyte antigen 
      low-incidence allele DRB1*15:140 in Taiwanese individuals: A case analysis.
PG  - 20-22
LID - 10.4103/tcmj.tcmj_72_18 [doi]
AB  - OBJECTIVE: Human leukocyte antigen (HLA)-DRB1*15:140 is a low-frequency allele in 
      the HLA-DRB1 locus. The aim of this study is to confirm the ethnicity of 
      DRB1*15:140 and to deduce a probable HLA-DRB1*15:140-associated HLA haplotype in 
      Taiwanese individuals. MATERIALS AND METHODS: A total of 1815 healthy unrelated 
      Taiwanese individuals and 14,562 unrelated mainland Chinese individuals were 
      tested for HLA using a sequence-based typing method. Polymerase chain reaction 
      was performed to amplify exons 2 and 3 of the HLA-A and HLA-B loci and exons 1 
      and 2 of the HLA-DRB1 locus using group-specific primer sets. The amplicons were 
      sequenced in both directions with the BigDye Terminator Cycle Sequencing Ready 
      Reaction Kit according to the manufacturer's protocols. RESULTS: The DNA sequence 
      of HLA-DRB1*15:140 is identical to DRB1*15:02:01:01 in exons 1 and 2, except at 
      residue 91 of DRB1*15:02:01:01 where a G in DRB1*15:02:01:01 is replaced by an A 
      in DRB1*15:140 (codon 2; GAC->AAC). The nucleotide substitution in exon 1 
      introduces a one amino acid substitution at residue 2 where an aspartic acid (D) 
      in DRB1*15:02:01:01 is replaced by an asparagine (N) in DRB1*15:140. We deduced 
      the probable HLA haplotype associated with DRB1*15:140 in Taiwanese to be 
      HLA-A*33:03-B*58:01-DRB1*15:140. CONCLUSION: Information on the ethnicity and 
      distribution of DRB1*15:140 and its deduced probable HLA haplotype in association 
      with the low-incidence allele is of value for HLA-testing laboratories for 
      reference purposes and can help bone marrow donor registries find compatible 
      donors for patients with this uncommon HLA allele.
FAU - Yang, Kuo-Liang
AU  - Yang KL
AD  - Laboratory of Immunogenetics, Tzu Chi Cord Blood Bank and Buddhist Tzu Chi Marrow 
      Donor Registry, Buddhist Tzu Chi Stem Cells Centre, Hualien Tzu Chi Hospital, 
      Hualien, Taiwan.
AD  - Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien, 
      Taiwan.
FAU - Zheng, Zheng-Zhong
AU  - Zheng ZZ
AD  - Department of Research, China Shanghai Tissuebank Diagnostics, Shanghai, China.
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Ci Ji Yi Xue Za Zhi
JT  - Ci ji yi xue za zhi = Tzu-chi medical journal
JID - 9514171
PMC - PMC6334561
OTO - NOTNLM
OT  - DRB1*15:140
OT  - Haplotype
OT  - Human leukocyte antigen
OT  - Taiwanese
OT  - Transplantation
COIS- There are no conflicts of interest.
EDAT- 2019/01/30 06:00
MHDA- 2019/01/30 06:01
PMCR- 2019/01/01
CRDT- 2019/01/30 06:00
PHST- 2019/01/30 06:00 [entrez]
PHST- 2019/01/30 06:00 [pubmed]
PHST- 2019/01/30 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - TCMJ-31-20 [pii]
AID - 10.4103/tcmj.tcmj_72_18 [doi]
PST - ppublish
SO  - Ci Ji Yi Xue Za Zhi. 2019 Jan-Mar;31(1):20-22. doi: 10.4103/tcmj.tcmj_72_18.