PMID- 30693312
OWN - NLM
STAT- MEDLINE
DCOM- 20190418
LR  - 20231213
IS  - 2373-2822 (Electronic)
IS  - 2373-2822 (Linking)
VI  - 6
IP  - 1
DP  - 2019 Jan-Feb
TI  - Methamphetamine Self-Administration Elicits Sex-Related Changes in Postsynaptic 
      Glutamate Transmission in the Prefrontal Cortex.
LID - 10.1523/ENEURO.0401-18.2018 [doi]
LID - ENEURO.0401-18.2018
AB  - Preclinical and clinical research has shown that females are more vulnerable to 
      the rewarding effects of stimulants, and it has been proposed that estrogens may 
      play a role in this enhanced sensitivity; however sex differences in 
      methamphetamine (METH)-induced neuroplasticity have not been explored. To address 
      this gap in knowledge, we recorded from the prelimbic area of the prefrontal 
      cortex (PL-PFC) of male and female rats following long access METH 
      self-administration (SA) and investigated the resulting long-term synaptic 
      neuroadaptations. Males and females took similar amounts of METH during SA; 
      however, female rats exhibit significant synaptic baseline differences when 
      compared to males. Furthermore, females exhibited a significant increase in 
      evoked excitatory currents. This increase in evoked glutamate was correlated with 
      increases in NMDA currents and was not affected by application of a GluN2B 
      selective blocker. We propose that METH SA selectively upregulates GluN2B-lacking 
      NMDA receptors (NMDAR) in the PFC of female rats. Our results may provide a 
      mechanistic explanation for the sex differences reported for METH addiction in 
      females.
FAU - Pena-Bravo, Jose Ignacio
AU  - Pena-Bravo JI
AUID- ORCID: 0000-0002-1307-3626
AD  - Department of Neuroscience, Medical University of South Carolina, Charleston, SC 
      29425.
FAU - Penrod, Rachel
AU  - Penrod R
AD  - Department of Neuroscience, Medical University of South Carolina, Charleston, SC 
      29425.
FAU - Reichel, Carmela M
AU  - Reichel CM
AD  - Department of Neuroscience, Medical University of South Carolina, Charleston, SC 
      29425.
FAU - Lavin, Antonieta
AU  - Lavin A
AUID- ORCID: 0000-0002-0056-7862
AD  - Department of Neuroscience, Medical University of South Carolina, Charleston, SC 
      29425.
LA  - eng
GR  - R25 GM113278/GM/NIGMS NIH HHS/United States
GR  - R25 GM072643/GM/NIGMS NIH HHS/United States
GR  - R21 DA045889/DA/NIDA NIH HHS/United States
GR  - R01 DA033049/DA/NIDA NIH HHS/United States
GR  - T32 DA007288/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190128
PL  - United States
TA  - eNeuro
JT  - eNeuro
JID - 101647362
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Amphetamine-Related Disorders/metabolism
MH  - Animals
MH  - Central Nervous System Stimulants/*administration & dosage
MH  - Female
MH  - Glutamic Acid/*metabolism
MH  - Male
MH  - Methamphetamine/*administration & dosage
MH  - Prefrontal Cortex/*drug effects/metabolism
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/metabolism
MH  - Self Administration
MH  - *Sex Characteristics
MH  - Synapses/drug effects/physiology
MH  - Synaptic Potentials/drug effects/physiology
MH  - Tissue Culture Techniques
PMC - PMC6348447
OTO - NOTNLM
OT  - NMDA
OT  - gluatamte
OT  - metampetamine
OT  - prefrontal cortex
OT  - sex
COIS- The authors do not have any conflict of interest to report.
EDAT- 2019/01/30 06:00
MHDA- 2019/04/19 06:00
PMCR- 2019/01/28
CRDT- 2019/01/30 06:00
PHST- 2018/10/16 00:00 [received]
PHST- 2018/12/17 00:00 [revised]
PHST- 2018/12/20 00:00 [accepted]
PHST- 2019/01/30 06:00 [entrez]
PHST- 2019/01/30 06:00 [pubmed]
PHST- 2019/04/19 06:00 [medline]
PHST- 2019/01/28 00:00 [pmc-release]
AID - eN-NWR-0401-18 [pii]
AID - 10.1523/ENEURO.0401-18.2018 [doi]
PST - epublish
SO  - eNeuro. 2019 Jan 28;6(1):ENEURO.0401-18.2018. doi: 10.1523/ENEURO.0401-18.2018. 
      eCollection 2019 Jan-Feb.