PMID- 30693528
OWN - NLM
STAT- MEDLINE
DCOM- 20190612
LR  - 20190613
IS  - 1099-0801 (Electronic)
IS  - 0269-3879 (Linking)
VI  - 33
IP  - 6
DP  - 2019 Jun
TI  - Quantitative analysis of different batches of raw, wine-processed, and 
      vinegar-processed Paeoniae Alba Radix using ultra-performance convergence 
      chromatography coupled with photo diode array detection.
PG  - e4485
LID - 10.1002/bmc.4485 [doi]
AB  - Supercritical fluid chromatography is a safe and ecofriendly analytical technique 
      that has not been fully applied to the analysis of traditional Chinese medicine. 
      This is the first study on the separation of six quality markers-paeoniflorin, 
      albiflorin, benzoyl paeoniflorin, oxypaeoniflorin, gallic acid and benzoic 
      acid-from raw, wine-baked and vinegar-baked Paeoniae Alba Radix (PAR) by 
      Supercritical fluid chromatography. Optimum separation was achieved on an HSS 
      C(18) SB column (100 x 3.0 mm, 1.8 mum particles) with a gradient elution of 
      high-purity carbon dioxide as mobile phase A and methanol-acetonitrile (70:30, 
      v/v) with 0.10% phosphoric acid as mobile phase B. The flow rate was set at 
      0.7 mL/min for 15.0 min. The method was validated in terms of the overall 
      intraday and interday precision, with relative standard deviations (RSDs) of 
      0.87-2.87 and 1.47-3.63%, respectively. The recoveries were 98.10-103.60% with an 
      RSD of 1.00-3.40%. The stability of the RSD values was in the range 1.10-3.78%. 
      The developed approach was successfully applied and provides a valuable reference 
      for the quality assessment of PAR and processed PAR. The results also revealed 
      that the standardization of processing technology is of great significance to the 
      fluctuations in quality before and after the processing of traditional Chinese 
      medicine.
CI  - (c) 2019 John Wiley & Sons, Ltd.
FAU - Yang, Liu
AU  - Yang L
AUID- ORCID: 0000-0002-9607-1107
AD  - Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang 
      University of Chinese Medicine, Harbin, P.R. China.
FAU - Jiang, Hai
AU  - Jiang H
AUID- ORCID: 0000-0002-2722-3330
AD  - Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang 
      University of Chinese Medicine, Harbin, P.R. China.
FAU - Guo, Xinyue
AU  - Guo X
AD  - Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang 
      University of Chinese Medicine, Harbin, P.R. China.
FAU - Hou, Ajiao
AU  - Hou A
AD  - Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang 
      University of Chinese Medicine, Harbin, P.R. China.
FAU - Man, Wenjing
AU  - Man W
AD  - Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang 
      University of Chinese Medicine, Harbin, P.R. China.
FAU - Xing, Xudong
AU  - Xing X
AD  - Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang 
      University of Chinese Medicine, Harbin, P.R. China.
FAU - Yan, Meiling
AU  - Yan M
AD  - Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang 
      University of Chinese Medicine, Harbin, P.R. China.
FAU - Yang, Bingyou
AU  - Yang B
AD  - Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang 
      University of Chinese Medicine, Harbin, P.R. China.
FAU - Wang, Qiuhong
AU  - Wang Q
AD  - Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang 
      University of Chinese Medicine, Harbin, P.R. China.
AD  - School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, 
      Guangzhou, P.R. China.
FAU - Kuang, Haixue
AU  - Kuang H
AD  - Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang 
      University of Chinese Medicine, Harbin, P.R. China.
LA  - eng
GR  - 2018RCD25/the Innovative Talents Funding of Heilongjiang University of Chinese 
      Medicine/
GR  - 81703684/National Natural Science Foundation of China/
GR  - 81803690/National Natural Science Foundation of China/
GR  - grant number 2013bs04/the Heilongjiang University of Chinese Medicine Doctoral 
      Innovation Foundation/
GR  - 20132327120003/the Specialized Research Fund for the Doctoral Program of Higher 
      Education of China/
GR  - UNPYSCT-2017219/University Nursing Program for Young Scholars with Creative 
      Talents in Heilongjiang Province/
GR  - LBH-Q16210/Heilongjiang Postdoctoral Scientific Research Developmental Fund/
GR  - H201324/Natural Science Foundation of Heilongjiang Province/
GR  - 2012RCQ20/Heilongjiang University of Chinese Medicine/
PT  - Journal Article
DEP - 20190225
PL  - England
TA  - Biomed Chromatogr
JT  - Biomedical chromatography : BMC
JID - 8610241
RN  - 0 (Biomarkers)
RN  - 0 (Glucosides)
RN  - 0 (Monoterpenes)
RN  - 0 (Plant Extracts)
RN  - 21AIQ4EV64 (peoniflorin)
RN  - 632XD903SP (Gallic Acid)
RN  - 8SKN0B0MIM (Benzoic Acid)
RN  - Q40Q9N063P (Acetic Acid)
SB  - IM
MH  - Acetic Acid/*chemistry
MH  - Benzoic Acid/analysis
MH  - Biomarkers/analysis/chemistry
MH  - Chromatography, Supercritical Fluid/*methods
MH  - Gallic Acid/analysis
MH  - Glucosides/analysis
MH  - Limit of Detection
MH  - Linear Models
MH  - Monoterpenes/analysis
MH  - Paeonia/*chemistry
MH  - *Plant Extracts/analysis/chemistry/standards
MH  - Reproducibility of Results
MH  - Wine
OTO - NOTNLM
OT  - Paeoniae Alba radix
OT  - processing
OT  - quality marker
OT  - supercritical fluid chromatography
EDAT- 2019/01/30 06:00
MHDA- 2019/06/14 06:00
CRDT- 2019/01/30 06:00
PHST- 2018/09/10 00:00 [received]
PHST- 2018/12/04 00:00 [revised]
PHST- 2019/01/07 00:00 [accepted]
PHST- 2019/01/30 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/01/30 06:00 [entrez]
AID - 10.1002/bmc.4485 [doi]
PST - ppublish
SO  - Biomed Chromatogr. 2019 Jun;33(6):e4485. doi: 10.1002/bmc.4485. Epub 2019 Feb 25.