PMID- 30693534
OWN - NLM
STAT- MEDLINE
DCOM- 20200430
LR  - 20210109
IS  - 1469-8986 (Electronic)
IS  - 0048-5772 (Print)
IS  - 0048-5772 (Linking)
VI  - 56
IP  - 6
DP  - 2019 Jun
TI  - Loneliness and biological responses to acute stress in people with Type 2 
      diabetes.
PG  - e13341
LID - 10.1111/psyp.13341 [doi]
LID - e13341
AB  - Loneliness is linked with all-cause mortality and coronary heart disease. Altered 
      neuroendocrine and inflammatory responses to stress constitute potential pathways 
      linking loneliness and ill-health. Stress responsivity is modified in people with 
      Type 2 diabetes, but it is unclear whether loneliness influences biological 
      stress responses in this population. We assessed interleukin-6 (IL-6), 
      interleukin-1 receptor antagonist (IL-1RA), monocyte chemoattractant protein-1 
      (MCP-1), and cortisol responses to acute stress in 135 people with Type 2 
      diabetes. Loneliness was measured used the Revised UCLA Loneliness Scale. 
      Loneliness was inversely associated with cortisol output poststress (B = -4.429, 
      p = 0.019) independent of age, sex, education, marital status, body mass index, 
      and smoking. Lonelier individuals had raised MCP-1 concentrations 75 min 
      poststress independent of covariates (B = 0.713, p = 0.022). No associations 
      between loneliness and IL-6 or IL-1RA concentrations were detected. These results 
      suggest that loneliness is associated with disturbances in stress responsivity in 
      people with diabetes, and the impact of loneliness on health in people with 
      diabetes may be mediated in part through dysregulation of inflammatory and 
      neuroendocrine systems. Future research is required to understand if such changes 
      increase the risk of poorer outcomes in this population.
CI  - (c) 2019 The Authors Psychophysiology published by Wiley Periodicals, Inc. on 
      behalf of Society for Psychophysiological Research.
FAU - Hackett, Ruth A
AU  - Hackett RA
AUID- ORCID: 0000-0002-5428-2950
AD  - Department of Behavioural Science and Health, University College London, London, 
      UK.
FAU - Poole, Lydia
AU  - Poole L
AD  - Department of Behavioural Science and Health, University College London, London, 
      UK.
FAU - Hunt, Elizabeth
AU  - Hunt E
AD  - Department of Behavioural Science and Health, University College London, London, 
      UK.
FAU - Panagi, Laura
AU  - Panagi L
AUID- ORCID: 0000-0001-6752-726X
AD  - Department of Behavioural Science and Health, University College London, London, 
      UK.
FAU - Steptoe, Andrew
AU  - Steptoe A
AD  - Department of Behavioural Science and Health, University College London, London, 
      UK.
LA  - eng
GR  - RG/10/005/28296/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190128
PL  - United States
TA  - Psychophysiology
JT  - Psychophysiology
JID - 0142657
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL1RN protein, human)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-6)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Aged
MH  - Chemokine CCL2/blood
MH  - Diabetes Mellitus, Type 2/complications/physiopathology/*psychology
MH  - Female
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Interleukin 1 Receptor Antagonist Protein/blood
MH  - Interleukin-6/blood
MH  - *Loneliness/psychology
MH  - Male
MH  - Middle Aged
MH  - Stress, Psychological/complications/physiopathology
PMC - PMC6563153
OTO - NOTNLM
OT  - Type 2 diabetes
OT  - cortisol
OT  - inflammation
OT  - loneliness
OT  - stress responses
EDAT- 2019/01/30 06:00
MHDA- 2020/05/01 06:00
PMCR- 2019/06/13
CRDT- 2019/01/30 06:00
PHST- 2018/11/02 00:00 [received]
PHST- 2018/12/14 00:00 [revised]
PHST- 2019/01/07 00:00 [accepted]
PHST- 2019/01/30 06:00 [pubmed]
PHST- 2020/05/01 06:00 [medline]
PHST- 2019/01/30 06:00 [entrez]
PHST- 2019/06/13 00:00 [pmc-release]
AID - PSYP13341 [pii]
AID - 10.1111/psyp.13341 [doi]
PST - ppublish
SO  - Psychophysiology. 2019 Jun;56(6):e13341. doi: 10.1111/psyp.13341. Epub 2019 Jan 
      28.