PMID- 30694370
OWN - NLM
STAT- MEDLINE
DCOM- 20200708
LR  - 20200708
IS  - 2366-0058 (Electronic)
VI  - 44
IP  - 5
DP  - 2019 May
TI  - Quantitative contrast-enhanced ultrasound of renal perfusion: a technology for 
      the assessment of early diabetic nephropathy in cynomolgus macaques with type 2 
      diabetes mellitus.
PG  - 1850-1857
LID - 10.1007/s00261-019-01908-5 [doi]
AB  - PURPOSE: The aim of this study was to investigate the effectiveness of 
      contrast-enhanced ultrasound (CEUS) in predicting early nephropathy in cynomolgus 
      macaques with spontaneous type 2 diabetes mellitus (T2DM). METHODS: Six 
      cynomolgus macaques with spontaneous T2DM and six normal cynomolgus macaques 
      (Group 1) were included in this study. The time-intensity curve was used to 
      obtain parameters such as peak values, red blood volume (RBV), red blood flow 
      (RBF), time to peak (TTP), and mean transit time (MTT). Biopsy renal tissue 
      samples were assessed histopathologically. Six cynomolgus macaques with 
      spontaneous T2DM were subgrouped into T2DM without nephropathy group (Group 2) 
      and T2DM with nephropathy group (Group 3) based on histopathological findings. 
      RESULTS: Peak value had the largest area under the curve comparing with RBF, RBV, 
      TTP, MTT. The sensitivity and specificity of peak value with cut-off value of 
      38.65 dB for the diagnosis of DN were 98.3% and 83%, respectively. Peak value, 
      RBV, and RBF in Group 3 was significantly decreased compared with Group 1 and 
      Group 2 (P = 0.000, x(2) = 23.99; P = 0.003, x(2) = 9.14; P = 0.02, x(2) = 5.14). 
      CONCLUSIONS: The perfusion parameter of peak value in CEUS might be useful in 
      predicting early diabetic nephropathy in spontaneous T2DM cynomolgus macaques.
FAU - Luo, Jieli
AU  - Luo J
AD  - Department of Ultrasound, The Second Affiliated Hospital of Zhejiang University 
      School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
FAU - Chen, Jianshe
AU  - Chen J
AD  - Department of Ultrasound, The Second Affiliated Hospital of Zhejiang University 
      School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
FAU - Sun, Yang
AU  - Sun Y
AD  - Department of Ultrasound, The Second Affiliated Hospital of Zhejiang University 
      School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
FAU - Zhou, Hang
AU  - Zhou H
AD  - Department of Ultrasound, The Second Affiliated Hospital of Zhejiang University 
      School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
FAU - Xu, Kailun
AU  - Xu K
AD  - Department of Pathology, The Second Affiliated Hospital of Zhejiang University 
      School of Medicine, Zhejiang, 310009, China.
FAU - Huang, Fengbo
AU  - Huang F
AD  - Department of Pathology, The Second Affiliated Hospital of Zhejiang University 
      School of Medicine, Zhejiang, 310009, China.
FAU - Huang, Pintong
AU  - Huang P
AUID- ORCID: 0000-0003-0747-5765
AD  - Department of Ultrasound, The Second Affiliated Hospital of Zhejiang University 
      School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China. 
      huangpintong@zju.edu.cn.
LA  - eng
GR  - No. 81420108018/National Natural Science Foundation of China/International
GR  - No. 81527803/National Natural Science Foundation of China/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Abdom Radiol (NY)
JT  - Abdominal radiology (New York)
JID - 101674571
RN  - 0 (Biomarkers)
RN  - 0 (Contrast Media)
RN  - 0 (Phospholipids)
RN  - 0 (contrast agent BR1)
RN  - WS7LR3I1D6 (Sulfur Hexafluoride)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood/urine
MH  - Biopsy, Large-Core Needle
MH  - Contrast Media
MH  - *Diabetes Mellitus, Type 2
MH  - Diabetic Nephropathies/*diagnostic imaging
MH  - Image Processing, Computer-Assisted
MH  - Macaca fascicularis
MH  - Male
MH  - Phospholipids
MH  - Sensitivity and Specificity
MH  - Sulfur Hexafluoride
MH  - Ultrasonography/*methods
OTO - NOTNLM
OT  - Cut-off value
OT  - Diabetes
OT  - Glomerular filtration rate
OT  - Histopathology
OT  - Nephropathy
EDAT- 2019/01/30 06:00
MHDA- 2020/07/09 06:00
CRDT- 2019/01/30 06:00
PHST- 2019/01/30 06:00 [pubmed]
PHST- 2020/07/09 06:00 [medline]
PHST- 2019/01/30 06:00 [entrez]
AID - 10.1007/s00261-019-01908-5 [pii]
AID - 10.1007/s00261-019-01908-5 [doi]
PST - ppublish
SO  - Abdom Radiol (NY). 2019 May;44(5):1850-1857. doi: 10.1007/s00261-019-01908-5.