PMID- 3069452
OWN - NLM
STAT- MEDLINE
DCOM- 19890421
LR  - 20190912
IS  - 0378-3782 (Print)
IS  - 0378-3782 (Linking)
VI  - 18
IP  - 1
DP  - 1988 Nov
TI  - The uterine artery blood flow velocity waveform in pathological pregnancy.
PG  - 45-57
AB  - Uterine artery blood flow velocity waveforms (FVW) were recorded longitudinally 
      in 41 women with undisturbed pregnancy as well as in 32 women with complicated 
      pregnancy at 4-week intervals from a gestational age of 18 weeks onwards. Of 
      these women, four did not complete the study. In a second group of 76 patients at 
      least one FVW was recorded after admission to the obstetrical department because 
      of complicated pregnancy. The Pulsatility-Index (PI) for normal pregnancy was 
      based on the results of the 41 women with undisturbed pregnancy (Mulders et al. 
      (1988) Early Hum. Dev., 17, 55-70). The complete study group (n = 145) was 
      divided in two groups, based on the value of the last measured uterine artery PI 
      before delivery in the abnormal PI group (PI greater than or equal to 1.02 before 
      32 weeks or PI greater than or equal to 0.91 after 32 weeks, n = 38) 
      hypertension, fetal distress during pregnancy, premature delivery, small for 
      gestational age babies (SGA) and lower placental weight were all significantly 
      increased. In each of the groups of patients with either SGA, fetal distress 
      during pregnancy, pre-existing hypertension with proteinuria and 
      pregnancy-induced hypertension with or without proteinuria the mean PI was 
      significantly increased as compared to the results in normal pregnancy. 
      Sensitivity and specificity of the last uterine artery PI for the detection of 
      SGA and/or fetal distress during pregnancy were 48.8% and 82.7%, respectively. 
      The longitudinally studied women (n = 73) were divided in two groups, based on 
      uterine artery PI before 32 weeks of gestation; in the abnormal PI group (PI 
      greater than or equal to 1.02, n = 12) pregnancy was more complicated by 
      premature delivery and low birth weight. Sensitivity for the early prediction of 
      pathological pregnancies (at least one pathological phenomenon as mentioned 
      above) was 30.4%, whereas specificity was 90.0%.
FAU - Mulders, L G
AU  - Mulders LG
AD  - Department of Obstetrics and Gynaecology, St. Radbound Hospital, Catholic 
      University of Nijmegen, The Netherlands.
FAU - Jongsma, H W
AU  - Jongsma HW
FAU - Wijn, P F
AU  - Wijn PF
FAU - Hein, P R
AU  - Hein PR
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Early Hum Dev
JT  - Early human development
JID - 7708381
SB  - IM
MH  - Arteries
MH  - Blood Flow Velocity
MH  - Female
MH  - Fetal Distress/diagnosis
MH  - Fetal Growth Retardation/diagnosis
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - *Maternal-Fetal Exchange
MH  - Pre-Eclampsia/diagnosis
MH  - Pregnancy
MH  - Pregnancy Complications/*diagnosis
MH  - *Prenatal Diagnosis
MH  - Prognosis
MH  - *Ultrasonography
MH  - Uterus/*blood supply
EDAT- 1988/11/01 00:00
MHDA- 1988/11/01 00:01
CRDT- 1988/11/01 00:00
PHST- 1988/11/01 00:00 [pubmed]
PHST- 1988/11/01 00:01 [medline]
PHST- 1988/11/01 00:00 [entrez]
AID - 0378-3782(88)90042-4 [pii]
AID - 10.1016/0378-3782(88)90042-4 [doi]
PST - ppublish
SO  - Early Hum Dev. 1988 Nov;18(1):45-57. doi: 10.1016/0378-3782(88)90042-4.