PMID- 30697285
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 1735-5303 (Print)
IS  - 2345-3656 (Electronic)
IS  - 1735-5303 (Linking)
VI  - 13
IP  - 2
DP  - 2018 Spring
TI  - Association of Sulfur Mustard-Induced Ocular Problems with Serum and Blood 
      Biochemical Parameters Changes.
PG  - 157-166
AB  - BACKGROUND & OBJECTIVE: Many biochemical features of sulfur mustard (SM) 
      intoxication have remained unknown. So far, the direct association between 
      biochemical parameter changes and ocular problems in patients exposed to SM is 
      not evaluated. The current study aimed at evaluating the associations between the 
      ocular findings in patients with SM intoxication and the changes of serum and 
      blood biochemical parameters. METHODS: In the current study, 372 patients exposed 
      to SM and 128 matched controls were compared concerning the association between 
      their ocular problems and biochemical parameters. Ocular problems include 
      photophobia, ocular surface discomfort (OSD), etc. Biochemical parameters include 
      uric acid, creatinine (Cr), hematocrit (HCT), total, direct and indirect 
      bilirubin, high-density lipoproteins (HDL), alanine aminotransferase (ALT), 
      calcium (Ca), fasting blood sugar (FBS), mean corpuscular hemoglobin 
      concentration (MCHC), etc. RESULTS: The SM-exposed group with photophobia, OSD, 
      tearing, blurred vision, abnormal tear status, and slit-lamp findings had 
      significantly higher mean serum and blood levels of uric acid, Cr, HCT, and total 
      and indirect bilirubin than the controls. The SM-exposed group with photophobia, 
      tearing, ocular pain, blurred vision, bulbar conjunctival and limbal 
      abnormalities had significantly higher mean serum and blood levels of HDL, ALT, 
      Ca, FBS, MCHC, and HDL, indirect and total bilirubin, compared to the control 
      group. CONCLUSION: The association of photophobia with uric acid, OSD and tearing 
      with Cr, photophobia with HDL, ocular pain with Ca, and blurred vision with FBS 
      may be explained for their known ocular effects in the SM-exposed subjects. 
      SM-induced biochemical changes may intensify the ocular problems induced by the 
      direct effects of SM.
FAU - Ghasemi, Hassan
AU  - Ghasemi H
AD  - Immunoregulation Research Center, Shahed University, Tehran, Iran.
AD  - Dept.of Ophthalmology, Shahed University, Tehran, Iran.
FAU - Askari, Nayere
AU  - Askari N
AD  - Dept.of Biology, Faculty of Basic Sciences, Shahid Bahonar University, Kerman, 
      Iran.
FAU - Naghizadeh, Mohammad Mehdi
AU  - Naghizadeh MM
AD  - Dept. of Biostatistics, Fasa University of Medical Sciences, Fasa, Fars Province, 
      Iran.
FAU - Kabudanian Ardestani, Susan
AU  - Kabudanian Ardestani S
AD  - Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
FAU - Moaiedmohseni, Sakine
AU  - Moaiedmohseni S
AD  - Immunoregulation Research Center, Shahed University, Tehran, Iran.
FAU - Vaez Mahdavi, Mohammad Reza
AU  - Vaez Mahdavi MR
AD  - Immunoregulation Research Center, Shahed University, Tehran, Iran.
FAU - Ghazanfari, Tooba
AU  - Ghazanfari T
AD  - Immunoregulation Research Center, Shahed University, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20180717
PL  - Iran
TA  - Iran J Pathol
JT  - Iranian journal of pathology
JID - 101515128
PMC - PMC6339492
OTO - NOTNLM
OT  - Blood Biochemical Parameters
OT  - Mustard Gas
OT  - Ocular Surface
OT  - Serum Biochemical Parameters
COIS- The authors declared no conflict of interest.
EDAT- 2019/01/31 06:00
MHDA- 2019/01/31 06:01
PMCR- 2018/03/01
CRDT- 2019/01/31 06:00
PHST- 2016/10/25 00:00 [received]
PHST- 2017/02/05 00:00 [accepted]
PHST- 2019/01/31 06:00 [entrez]
PHST- 2019/01/31 06:00 [pubmed]
PHST- 2019/01/31 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - ijp-13-157 [pii]
PST - ppublish
SO  - Iran J Pathol. 2018 Spring;13(2):157-166. Epub 2018 Jul 17.