PMID- 30697396
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 1989-5488 (Print)
IS  - 1989-5488 (Electronic)
IS  - 1989-5488 (Linking)
VI  - 11
IP  - 1
DP  - 2019 Jan
TI  - Actinic cheilitis and lip squamous cell carcinoma: Literature review and new data 
      from Brazil.
PG  - e62-e69
LID - 10.4317/jced.55133 [doi]
AB  - BACKGROUND: To investigate the prevalence of malignant and potentially malignant 
      lesions of the lip in an oral pathology service and to compare these data with a 
      literature review. MATERIAL AND METHODS: A total of 3173 biopsy reports and 
      histopathological records were analyzed. Cases with a histological diagnosis of 
      actinic cheilitis (AC) with or without epithelial dysplasia, in situ carcinoma, 
      or lip squamous cell carcinoma (LSCC) were included. A comprehensive literature 
      review was conducted to investigate the prevalence of AC and/or LSCC. RESULTS: 
      124 cases (3.91%) were included, 75 (60.5%) had some degree of epithelial 
      dysplasia and 31 (25.0%) were LSCC. Clinically, most of the lesions were 
      diagnosed as AC (50.8%); however, eight cases clinically reported as AC were 
      histologically diagnosed as LSCC. Regarding clinical characteristics, most 
      individuals were fair-skinned male, with mean age of 54.3+/-12.3 years, and with a 
      history of long-term solar exposure. Furthermore, 18 articles were selected from 
      the literature, showing that the lower lip was predominantly affected and that 
      most individuals were males, fair-skinned, and older than 40 years. CONCLUSIONS: 
      Since most of the cases diagnosed clinically as AC presented some degree of 
      epithelial dysplasia, it is important to emphasize the value of biopsy and the 
      histological evaluation of this lesion. Key words:Actinic cheilitis, Precancerous 
      conditions, In situ carcinoma, Oral diagnosis, Mouth neoplasms.
FAU - Mello, Fernanda-Weber
AU  - Mello FW
AD  - Postgraduate Program in Dentistry, Federal University of Santa Catarina, 
      Florianopolis, Santa Catarina, Brazil.
FAU - Melo, Gilberto
AU  - Melo G
AD  - Postgraduate Program in Dentistry, Federal University of Santa Catarina, 
      Florianopolis, Santa Catarina, Brazil.
FAU - Modolo, Filipe
AU  - Modolo F
AD  - Department of Pathology, Federal University of Santa Catarina, Florianopolis, 
      Santa Catarina, Brazil.
FAU - Rivero, Elena-Riet-Correa
AU  - Rivero ER
AD  - Department of Pathology, Federal University of Santa Catarina, Florianopolis, 
      Santa Catarina, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190101
PL  - Spain
TA  - J Clin Exp Dent
JT  - Journal of clinical and experimental dentistry
JID - 101603132
PMC - PMC6343992
COIS- Conflict of interest statement: The authors have declared that no conflict of 
      interest exist.
EDAT- 2019/01/31 06:00
MHDA- 2019/01/31 06:01
PMCR- 2019/01/01
CRDT- 2019/01/31 06:00
PHST- 2018/07/10 00:00 [received]
PHST- 2018/12/10 00:00 [accepted]
PHST- 2019/01/31 06:00 [entrez]
PHST- 2019/01/31 06:00 [pubmed]
PHST- 2019/01/31 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 55133 [pii]
AID - 10.4317/jced.55133 [doi]
PST - epublish
SO  - J Clin Exp Dent. 2019 Jan 1;11(1):e62-e69. doi: 10.4317/jced.55133. eCollection 
      2019 Jan.