PMID- 30699847
OWN - NLM
STAT- MEDLINE
DCOM- 20190403
LR  - 20200225
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Print)
IS  - 0165-0327 (Linking)
VI  - 245
DP  - 2019 Feb 15
TI  - Inflammation as a unique marker of suicide ideation distinct from depression 
      syndrome among U.S. adults.
PG  - 1052-1060
LID - S0165-0327(18)31307-7 [pii]
LID - 10.1016/j.jad.2018.11.046 [doi]
AB  - BACKGROUND: Recent evidence suggests that pro-inflammatory states may be 
      independently associated with the risk of suicidality, above and beyond 
      depression. This study assesses whether four indicators of inflammation, 
      circulating levels of C-reactive protein (CRP), white blood cell (WBC) count and 
      immunoglobulin E (IgE), and dietary inflammatory potential, measured using the 
      Dietary Inflammatory Index(R) (DII), distinguish suicidal ideation (SI) from major 
      depression (MD). METHODS: Data come from multiple cycles of the US National 
      Health and Nutrition Examination Survey (N(CRP&WBC)( )= 13,912; 
      N(DII)( )= 17,076; N(IgE)( )= 4,060). MD was measured using the Patient Health 
      Questionnaire-9 (PHQ-9); SI was indicated by the last item of the PHQ-9. To 
      assess SI independent from MD, participants were classified into four categories: 
      SI with MD, SI without MD, MD without SI, and neither MD nor SI. Regression 
      models were used to assess the relationship between indicators of inflammation 
      and SI with and without MD. RESULTS: None of the inflammatory indicators were 
      able to distinguish SI status among MD cases. DII was associated with SI among 
      individuals without MD. CRP, DII, and WBC were associated with MD. No 
      associations were found for IgE. LIMITATIONS: Cross-section data prevent drawing 
      causal conclusions. Underreporting of MD and suicidal ideation and measurement of 
      habitual diet using 24 h dietary recalls are also weaknesses. CONCLUSION: Dietary 
      inflammatory potential was associated with suicide ideation among US adults with 
      and without depression. Diet may play a role in suicide ideation and more 
      empirical evidence is needed to determine whether nutritional protocols could aid 
      in the treatment of suicidal behaviors. Findings did not support inflammatory 
      factors having a relationship with suicide ideation distinct from depression.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Bergmans, Rachel S
AU  - Bergmans RS
AD  - UM SPH Department of Epidemiology, University of Michigan, 1415 Washington 
      Heights, Ann Arbor, MI 48109, United States.
FAU - Kelly, Kristen M
AU  - Kelly KM
AD  - UM SPH Department of Epidemiology, University of Michigan, 1415 Washington 
      Heights, Ann Arbor, MI 48109, United States.
FAU - Mezuk, Briana
AU  - Mezuk B
AD  - UM SPH Department of Epidemiology, University of Michigan, 1415 Washington 
      Heights, Ann Arbor, MI 48109, United States. Electronic address: 
      bmezuk@umich.edu.
LA  - eng
GR  - T32 MH073553/MH/NIMH NIH HHS/United States
GR  - T32 HG000040/HG/NHGRI NIH HHS/United States
GR  - K01 MH093642/MH/NIMH NIH HHS/United States
GR  - P2C HD047873/HD/NICHD NIH HHS/United States
GR  - L30 TR002505/TR/NCATS NIH HHS/United States
GR  - T32 HD007014/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20181106
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Depressive Disorder/blood/*diagnosis/psychology
MH  - Diet
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Inflammation/*complications
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Patient Health Questionnaire
MH  - Regression Analysis
MH  - Risk Factors
MH  - *Suicidal Ideation
MH  - United States
MH  - Young Adult
PMC - PMC6448785
MID - NIHMS1012738
OTO - NOTNLM
OT  - Allergies
OT  - Depression
OT  - Diet
OT  - Inflammation
OT  - Leukocytes
OT  - Suicide
COIS- Conflicts of interest The authors report no biomedical financial interests or 
      potential conflicts of interest.
EDAT- 2019/02/01 06:00
MHDA- 2019/04/04 06:00
PMCR- 2019/04/04
CRDT- 2019/02/01 06:00
PHST- 2018/06/18 00:00 [received]
PHST- 2018/09/19 00:00 [revised]
PHST- 2018/11/03 00:00 [accepted]
PHST- 2019/02/01 06:00 [entrez]
PHST- 2019/02/01 06:00 [pubmed]
PHST- 2019/04/04 06:00 [medline]
PHST- 2019/04/04 00:00 [pmc-release]
AID - S0165-0327(18)31307-7 [pii]
AID - 10.1016/j.jad.2018.11.046 [doi]
PST - ppublish
SO  - J Affect Disord. 2019 Feb 15;245:1052-1060. doi: 10.1016/j.jad.2018.11.046. Epub 
      2018 Nov 6.