PMID- 30701003
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 1918-3003 (Print)
IS  - 1918-3011 (Electronic)
IS  - 1918-3003 (Linking)
VI  - 11
IP  - 2
DP  - 2019 Feb
TI  - Assessment of Salivary Nitric Oxide Levels in Elite University Athletes in Japan: 
      Findings From a Cross Sectional Study Design.
PG  - 114-120
LID - 10.14740/jocmr3670 [doi]
AB  - BACKGROUND: High-intensity exercise affects the level of salivary nitric oxide 
      (NO) with an impact on oxidative stress such as a reactive nitrogen-oxide 
      species. However, in athletes with high-intensity training, the relationship 
      between salivary NO levels and oxidative stress is yet to be clear. Additionally, 
      the association of salivary NO levels and the common health disorders of athletes 
      is unknown. Thus, the aim of this cross-sectional study was to clarify the 
      relationship between salivary NO levels and oxidative stress, and the 
      health/medical disorders existing in elite class university athletes. METHODS: In 
      250 athletes (males, 151 and females, 99) from undergraduate levels of Japanese 
      University, we investigated the relationship between levels of salivary NO and 
      oxidative stress markers: derived reactive oxygen species (d-ROMs) and biological 
      antioxidant potential (BAP), and also examined that whether salivary NO levels 
      are associated with diseases. RESULTS: There were no significant association 
      between the levels of salivary NO and oxidative stress markers (such as d-ROM and 
      BAP). From the questionnaire, asthma was the most prevalent as evident from 
      medical history of the athletes. Additionally, the salivary NO levels were higher 
      (520 +/- 43 micromol/L vs. 375 +/- 13 micromol/L, P < 0.05) in the asthma group (n = 9) than 
      in the non-asthma group (n = 241). We determined the optimal cut-off value (P = 
      0.019) of the salivary NO levels for asthma was 425 micromol/L, with a sensitivity of 
      88.9% and specificity of 61.8% (area under the curve (AUC), 0.73). CONCLUSIONS: 
      Our results suggest that the high levels of salivary NO in trained university 
      athletes in Japan may potentially predict asthma. And this salivary NO level is 
      not associated with markers of oxidative stress and existing diseases in athletes 
      studied here.
FAU - Sone, Ryota
AU  - Sone R
AD  - Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
FAU - Matsuba, Kai
AU  - Matsuba K
AD  - Tsukuba Sports Medicine and Health Science Center, University of Tsukuba 
      Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki 305-8576, Japan.
FAU - Tahara, Rei
AU  - Tahara R
AD  - Sports Research and Development Core, University of Tsukuba, 1-1-1 Tennodai, 
      Tsukuba, Ibaraki 305-8577, Japan.
FAU - Eda, Nobuhiko
AU  - Eda N
AD  - Faculty of Sports Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, 
      Saitama 359-1192, Japan.
FAU - Kosaki, Keisei
AU  - Kosaki K
AD  - Faculty of Health and Sports Sciences, University of Tsukuba, 1-1-1 Tennodai, 
      Tsukuba, Ibaraki 305-8577, Japan.
FAU - Jesmin, Subrina
AU  - Jesmin S
AD  - Faculty of Health and Sports Sciences, University of Tsukuba, 1-1-1 Tennodai, 
      Tsukuba, Ibaraki 305-8577, Japan.
FAU - Miyakawa, Shumpei
AU  - Miyakawa S
AD  - Faculty of Health and Sports Sciences, University of Tsukuba, 1-1-1 Tennodai, 
      Tsukuba, Ibaraki 305-8577, Japan.
FAU - Watanabe, Koichi
AU  - Watanabe K
AD  - Faculty of Health and Sports Sciences, University of Tsukuba, 1-1-1 Tennodai, 
      Tsukuba, Ibaraki 305-8577, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190105
PL  - Canada
TA  - J Clin Med Res
JT  - Journal of clinical medicine research
JID - 101538301
PMC - PMC6340678
OTO - NOTNLM
OT  - Asthma
OT  - Condition marker
OT  - Japanese athletes
OT  - Nitric oxide
OT  - Oxidative stress
COIS- No potential conflict of interest was disclosed.
EDAT- 2019/02/01 06:00
MHDA- 2019/02/01 06:01
PMCR- 2019/01/05
CRDT- 2019/02/01 06:00
PHST- 2018/10/22 00:00 [received]
PHST- 2018/12/04 00:00 [accepted]
PHST- 2019/02/01 06:00 [entrez]
PHST- 2019/02/01 06:00 [pubmed]
PHST- 2019/02/01 06:01 [medline]
PHST- 2019/01/05 00:00 [pmc-release]
AID - 10.14740/jocmr3670 [doi]
PST - ppublish
SO  - J Clin Med Res. 2019 Feb;11(2):114-120. doi: 10.14740/jocmr3670. Epub 2019 Jan 5.