PMID- 30701360
OWN - NLM
STAT- MEDLINE
DCOM- 20200228
LR  - 20200309
IS  - 1432-1327 (Electronic)
IS  - 0949-8257 (Linking)
VI  - 24
IP  - 2
DP  - 2019 Mar
TI  - Influence of methionine-ruthenium complex on the fibril formation of human islet 
      amyloid polypeptide.
PG  - 179-189
LID - 10.1007/s00775-019-01637-6 [doi]
AB  - The abnormal aggregation and deposition of human islet amyloid polypeptide 
      (hIAPP) are implicated in the pathogeny of type 2 diabetes mellitus (T2DM). Many 
      aromatic ring-containing Ru complexes inhibit the aggregation of hIAPP. A new Ru 
      complex Ru(bipy)(met)(2).3H(2)O (1), where bipy is 2,2'-bipyridine and met is 
      methionine, was synthesized and employed to resist the fibril formation of hIAPP 
      and to promote the biocompatibility of metal complexes. Two polypyridyl Ru 
      complexes, namely [Ru(bipy)(3)]Cl(2)(2) and Ru(bipy)(2)Cl(2)(3), were used for 
      comparison. Results reveal that the three Ru complexes can inhibit hIAPP 
      aggregation and depolymerize mature hIAPP fibrils. Interaction studies show that 
      Ru complexes bind to hIAPP through metal coordination, hydrophobic interaction, 
      and other intermolecular forces. The binding of the three compounds is 
      spontaneous and exothermic. The compounds also rescue peptide-induced 
      cytotoxicity to some extent. Similar to 3, the novel methionine-Ru complex 1 
      exhibits an enhanced inhibitory effect and binding affinity to hIAPP possibly 
      because of the smaller steric hindrance and more profitable molecular 
      configuration of 1 than those of 2. The newly designed amino acid-Ru complex may 
      provide new insights into the treatment of T2DM and related amyloidosis diseases. 
      Methionine-Ru complex effectively impedes the fibril formation of human islet 
      amyloid polypeptide.
FAU - Gong, Gehui
AU  - Gong G
AD  - Department of Chemistry, Renmin University of China, Beijing, 100872, China.
FAU - Xu, Jufei
AU  - Xu J
AD  - Department of Chemistry, Renmin University of China, Beijing, 100872, China.
FAU - Huang, Xiangyi
AU  - Huang X
AD  - Department of Chemistry, Renmin University of China, Beijing, 100872, China.
FAU - Du, Weihong
AU  - Du W
AD  - Department of Chemistry, Renmin University of China, Beijing, 100872, China. 
      whdu@ruc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190130
PL  - Germany
TA  - J Biol Inorg Chem
JT  - Journal of biological inorganic chemistry : JBIC : a publication of the Society 
      of Biological Inorganic Chemistry
JID - 9616326
RN  - 0 (Coordination Complexes)
RN  - 0 (Islet Amyloid Polypeptide)
RN  - 7UI0TKC3U5 (Ruthenium)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Coordination Complexes/chemical synthesis/chemistry/*pharmacology
MH  - Humans
MH  - Islet Amyloid Polypeptide/*antagonists & inhibitors/metabolism
MH  - Methionine/chemistry/*pharmacology
MH  - Molecular Structure
MH  - Particle Size
MH  - Rats
MH  - Ruthenium/chemistry/*pharmacology
MH  - Surface Properties
OTO - NOTNLM
OT  - Fibril formation
OT  - Inhibition
OT  - Ruthenium complexes
OT  - hIAPP
EDAT- 2019/02/01 06:00
MHDA- 2020/02/29 06:00
CRDT- 2019/02/01 06:00
PHST- 2018/10/19 00:00 [received]
PHST- 2019/01/14 00:00 [accepted]
PHST- 2019/02/01 06:00 [pubmed]
PHST- 2020/02/29 06:00 [medline]
PHST- 2019/02/01 06:00 [entrez]
AID - 10.1007/s00775-019-01637-6 [pii]
AID - 10.1007/s00775-019-01637-6 [doi]
PST - ppublish
SO  - J Biol Inorg Chem. 2019 Mar;24(2):179-189. doi: 10.1007/s00775-019-01637-6. Epub 
      2019 Jan 30.