PMID- 30702022
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20190613
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 138
IP  - 12
DP  - 2018 Dec
TI  - The correlation of immunologic derangement and juvenile recurrent parotitis: an 
      investigation of the laboratory immunological observation.
PG  - 1112-1116
LID - 10.1080/00016489.2018.1515498 [doi]
AB  - BACKGROUND: Juvenile recurrent parotitis (JRP) is defined as recurrent parotid 
      inflammation, generally associated with nonobstructive sialectasis of the parotid 
      gland. In addition, the etiology remains unclear, probably immunologically 
      mediated. AIM: The purposes of the present study were to report the relationship 
      between JRP and immune function from the measurement of the JRP patients' 
      immunoglobulins and T-lymphocyte subset. METHODS: Immunologic assay from 2014 to 
      2017 of 100 children diagnosed with JRP at Shanghai Ninth Hospital compared with 
      the 100 normal children by age. RESULTS: The CD4 level of JRP children aged 
      >6 years was significant lower than the one of JRP preschool children (p < .05), 
      while the IgG level was significant higher than the one of the JRP preschool 
      children (p < .05). In comparison with the normal children, the value of CD8 T 
      cells, immunoglobulin G (IgG), immunoglobulin E (IgE), immunoglobulin A (IgA) and 
      C3 (p < .01) of JRP children was significant higher, while the value of CD4 T 
      cells was lower (p < .01) in spite of age. What is more, the value of CD8 T cells 
      of JRP preschool children was much significant higher than the one of the normal 
      preschool children (p < .01). CONCLUSION: The immune function of JRP patients may 
      become disorder: the suppression cellular immune function and inadequate humoral 
      immune expression.
FAU - Wu, Shufeng
AU  - Wu S
AD  - a Department of Oral Surgery , Shanghai Jiaotong University School of Medicine , 
      Shanghai , China.
FAU - Shi, Huan
AU  - Shi H
AD  - a Department of Oral Surgery , Shanghai Jiaotong University School of Medicine , 
      Shanghai , China.
FAU - Cao, Ningning
AU  - Cao N
AD  - a Department of Oral Surgery , Shanghai Jiaotong University School of Medicine , 
      Shanghai , China.
FAU - Ye, Lei
AU  - Ye L
AD  - a Department of Oral Surgery , Shanghai Jiaotong University School of Medicine , 
      Shanghai , China.
FAU - Yu, Chuangqi
AU  - Yu C
AD  - a Department of Oral Surgery , Shanghai Jiaotong University School of Medicine , 
      Shanghai , China.
FAU - Zheng, Lingyan
AU  - Zheng L
AD  - a Department of Oral Surgery , Shanghai Jiaotong University School of Medicine , 
      Shanghai , China.
LA  - eng
PT  - Journal Article
DEP - 20190131
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - Parotitis, Juvenile Recurrent
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Analysis of Variance
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Female
MH  - Hospitals, Public
MH  - Humans
MH  - Immunoglobulin A/analysis/immunology
MH  - Immunoglobulin G/analysis/immunology
MH  - Male
MH  - Parotid Gland/immunology
MH  - Parotitis/*diagnosis/*immunology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Sex Factors
OTO - NOTNLM
OT  - Juvenile recurrent parotitis
OT  - immune function
OT  - immunologic derangement
EDAT- 2019/02/01 06:00
MHDA- 2019/06/14 06:00
CRDT- 2019/02/01 06:00
PHST- 2019/02/01 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/02/01 06:00 [entrez]
AID - 10.1080/00016489.2018.1515498 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2018 Dec;138(12):1112-1116. doi: 10.1080/00016489.2018.1515498. 
      Epub 2019 Jan 31.