PMID- 30702560
OWN - NLM
STAT- MEDLINE
DCOM- 20190226
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 5
DP  - 2019 Feb
TI  - Cytokines concentrations in aqueous humor of eyes with uveal melanoma.
PG  - e14030
LID - 10.1097/MD.0000000000014030 [doi]
LID - e14030
AB  - Uveal melanoma (UM) is the major intraocular malignancy in adults, of which the 
      molecular biology is still unknown. Therefore, this study was designed to 
      determine the aqueous concentrations of angiogenic, inflammatory, and chemotactic 
      cytokines in eyes with UM.Aqueous humor samples were collected from 38 patients 
      with UM and 22 patients undergoing cataract surgery. Interleukin 6, 8 (IL-6, 
      IL-8, respectively), interferon-inducible protein-10 (IP-10), placental growth 
      factor1 (PIGF1), regulated on activation, normal T Cell expressed and secreted 
      (RANTES), monocyte chemoattractant protein-1 (MCP-1), nerve growth factor-beta 
      (NGF-beta), epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), 
      and vascular endothelia growth factor A (VEGF-A) were assessed by multiplex bead 
      assay.In the study group, significantly higher concentrations of IL-6 (P = .006), 
      IL-8 (P = .018), IP-10 (P = .004), RANTES (P = .008), MCP-1 (P = .02), NGF-beta 
      (P = .013), EGF (P < .001), PIGF1 (P = .01), bFGF (P = .016), and VEGF (P = .017) 
      were measured, when compared with the control group.Several angiogenic, 
      inflammatory, and chemotactic cytokines are highly expressed in the aqueous humor 
      of the UM eyes, which provides new insights into the pathophysiology of UM and 
      could be potential targets for treatment.
FAU - Cheng, Yong
AU  - Cheng Y
AD  - Department of Ophthalmology, Peking University People's Hospital, Eye Diseases 
      and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of 
      Retinal and Choroid Diseases, College of Optometry, Peking University Health 
      Science Center.
FAU - Feng, Jing
AU  - Feng J
AD  - Department of Ophthalmology, Peking University People's Hospital, Eye Diseases 
      and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of 
      Retinal and Choroid Diseases, College of Optometry, Peking University Health 
      Science Center.
AD  - Department of Ophthalmology, Beijing ChaoYang Hospital, Beijing, China.
FAU - Zhu, Xuemei
AU  - Zhu X
AD  - Department of Ophthalmology, Peking University People's Hospital, Eye Diseases 
      and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of 
      Retinal and Choroid Diseases, College of Optometry, Peking University Health 
      Science Center.
FAU - Liang, Jianhong
AU  - Liang J
AD  - Department of Ophthalmology, Peking University People's Hospital, Eye Diseases 
      and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of 
      Retinal and Choroid Diseases, College of Optometry, Peking University Health 
      Science Center.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - Uveal melanoma
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aqueous Humor/*cytology
MH  - Biomarkers, Tumor
MH  - Cataract Extraction
MH  - Cytokines/*biosynthesis
MH  - Epidermal Growth Factor/biosynthesis
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/metabolism
MH  - Male
MH  - Melanoma/immunology/*pathology
MH  - Middle Aged
MH  - Uveal Neoplasms/immunology/*pathology
MH  - Vascular Endothelial Growth Factor A/biosynthesis
PMC - PMC6380850
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2019/02/01 06:00
MHDA- 2019/02/27 06:00
PMCR- 2019/02/01
CRDT- 2019/02/01 06:00
PHST- 2019/02/01 06:00 [entrez]
PHST- 2019/02/01 06:00 [pubmed]
PHST- 2019/02/27 06:00 [medline]
PHST- 2019/02/01 00:00 [pmc-release]
AID - 00005792-201902010-00009 [pii]
AID - MD-D-18-06822 [pii]
AID - 10.1097/MD.0000000000014030 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Feb;98(5):e14030. doi: 10.1097/MD.0000000000014030.