PMID- 30702596
OWN - NLM
STAT- MEDLINE
DCOM- 20190207
LR  - 20221207
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 5
DP  - 2019 Feb
TI  - Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with type 
      2 diabetes mellitus in Chinese Korean ethnicity population.
PG  - e14288
LID - 10.1097/MD.0000000000014288 [doi]
LID - e14288
AB  - Presently, data on the type 2 diabetes mellitus (T2DM) in Chinese Korean 
      ethnicity are very scarce. This study aimed to explore the relationship between 
      the transcription factor 7-like 2 (TCF7L2) and T2DM in Chinese Korean ethnicity 
      population. This case-control study involved 43 T2DM Chinese Korean ethnicity 
      patients (T2DM group) and 43 healthy Chinese Korean ethnicity normoglycemic 
      subjects as controls (Control group). All included participants aged from 40 to 
      75 years old. Clinical and biological data were collected to determine the 
      phenotypic traits. The restriction fragment length polymorphism-polymerase chain 
      reaction was used to analyze the TCF7L2 by genotyping for rs7903146 (C/T). 
      Spectrophotometer with Chronolab kits was used to conduct the biochemical 
      analyses. TCF7L2 was associated with T2DM in the Chinese Korean ethnicity 
      population (P < .01 for alleles, and P < .05 for genotypes). Significant 
      differences were found 2 groups regarding the T allele (37.2% T2DM patients vs 
      15.1% healthy subjects, P < .01), and G allele (62.8% T2DM patients vs 84.9% 
      healthy subjects, P < .01). The risk genotypes were GG (83.7% T2DM patients, vs 
      44.2% healthy control, P < .01), GT (4.7% T2DM patients, vs 20.9% healthy 
      control, P = .04), and TT (11.6% T2DM patients, vs 34.9% healthy control, 
      P = .01). The results of this study demonstrated that TCF7L2 is associated with 
      T2DM in the Chinese Korean ethnicity population, which is an important risk 
      factor for T2DM in this population.
FAU - Zhou, Kui-Chen
AU  - Zhou KC
AD  - Department of Laboratory.
FAU - Liu, Hong-Wei
AU  - Liu HW
AD  - Department of Ophthalmology.
FAU - Wang, Chen
AU  - Wang C
AD  - Department of Neurology.
FAU - Fu, Yan-Jun
AU  - Fu YJ
AD  - Department of Laboratory.
FAU - Jin, Feng
AU  - Jin F
AD  - Department of Surgery, First Affiliated Hospital of Jiamusi University, Jiamusi, 
      China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/*ethnology/*genetics
MH  - Female
MH  - Humans
MH  - Korea/ethnology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Transcription Factor 7-Like 2 Protein/*genetics
PMC - PMC6380799
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2019/02/01 06:00
MHDA- 2019/02/08 06:00
PMCR- 2019/02/01
CRDT- 2019/02/01 06:00
PHST- 2019/02/01 06:00 [entrez]
PHST- 2019/02/01 06:00 [pubmed]
PHST- 2019/02/08 06:00 [medline]
PHST- 2019/02/01 00:00 [pmc-release]
AID - 00005792-201902010-00045 [pii]
AID - MD-D-18-09121 [pii]
AID - 10.1097/MD.0000000000014288 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Feb;98(5):e14288. doi: 10.1097/MD.0000000000014288.