PMID- 30703869
OWN - NLM
STAT- MEDLINE
DCOM- 20190422
LR  - 20240204
IS  - 0219-1032 (Electronic)
IS  - 1016-8478 (Print)
IS  - 1016-8478 (Linking)
VI  - 42
IP  - 2
DP  - 2019 Feb 28
TI  - Alleviation of Ultraviolet-B Radiation-Induced Photoaging by a TNFR Antagonistic 
      Peptide, TNFR2-SKE.
PG  - 151-160
LID - 10.14348/molcells.2018.0423 [doi]
AB  - Ultraviolet (UV) radiation of the sunlight, especially UVA and UVB, is the 
      primary environmental cause of skin damage, including topical inflammation, 
      premature skin aging, and skin cancer. Previous reports show that activation of 
      nuclear factor-kappaB (NF-kappaB) in human skin fibroblasts and keratinocytes after UV 
      exposure induces the expression and release of proinflammatory cytokines, such as 
      interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha), and subsequently leads 
      to the production of matrix metalloproteases (MMPs) and growth factor basic 
      fibroblast growth factor (bFGF). Here, we demonstrated that TNFR2-SKEE and 
      TNFR2-SKE, oligopeptides from TNF receptor-associated factor 2 (TRAF2)-binding 
      site of TNF receptor 2 (TNFR2), strongly inhibited the interaction of TNFR1 as 
      well as TNFR2 with TRAF2. In particular, TNFR2-SKE suppressed UVB- or 
      TNF-alpha-induced nuclear translocalization of activated NF-kappaB in mouse fibroblasts. 
      It decreased the expression of bFGF, MMPs, and COX2, which were upregulated by 
      TNF-alpha, and increased procollagen production, which was reduced by TNF-alpha. 
      Furthermore, TNFR2-SKE inhibited the UVB-induced proliferation of keratinocytes 
      and melanocytes in the mouse skin and the infiltration of immune cells into 
      inflamed tissues. These results suggest that TNFR2-SKE may possess the clinical 
      potency to alleviate UV-induced photoaging in human skin.
FAU - Lee, Kyoung-Jin
AU  - Lee KJ
AD  - Department of Anatomy and Cell Biology, School of Medicine, Kangwon National 
      University, Chuncheon 24341, Korea.
FAU - Park, Kyeong Han
AU  - Park KH
AD  - Department of Anatomy and Cell Biology, School of Medicine, Kangwon National 
      University, Chuncheon 24341, Korea.
FAU - Hahn, Jang-Hee
AU  - Hahn JH
AD  - Department of Anatomy and Cell Biology, School of Medicine, Kangwon National 
      University, Chuncheon 24341, Korea.
LA  - eng
PT  - Journal Article
DEP - 20190124
PL  - United States
TA  - Mol Cells
JT  - Molecules and cells
JID - 9610936
RN  - 0 (NF-kappa B)
RN  - 0 (Peptides)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (TNF Receptor-Associated Factor 2)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Cell Proliferation/drug effects
MH  - Fibroblasts/drug effects/metabolism
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Hyperplasia
MH  - Inflammation/pathology
MH  - Lymphocytes/drug effects/metabolism
MH  - Melanocytes/drug effects/metabolism/pathology
MH  - Mice
MH  - NF-kappa B/metabolism
MH  - NIH 3T3 Cells
MH  - Peptides/*pharmacology
MH  - Protein Binding/drug effects
MH  - Receptors, Tumor Necrosis Factor, Type I/antagonists & inhibitors/metabolism
MH  - Receptors, Tumor Necrosis Factor, Type II/*antagonists & inhibitors/metabolism
MH  - Skin/drug effects/pathology/radiation effects
MH  - Skin Aging/*drug effects/*radiation effects
MH  - TNF Receptor-Associated Factor 2/metabolism
MH  - Tumor Necrosis Factor-alpha/pharmacology
MH  - *Ultraviolet Rays
PMC - PMC6399009
OTO - NOTNLM
OT  - NF-kappaB
OT  - TNFR antagonist
OT  - TNFR2-SKE
OT  - inflammation
OT  - photoaging
EDAT- 2019/02/02 06:00
MHDA- 2019/04/23 06:00
PMCR- 2019/02/28
CRDT- 2019/02/02 06:00
PHST- 2018/11/08 00:00 [received]
PHST- 2018/12/13 00:00 [revised]
PHST- 2019/01/01 00:00 [accepted]
PHST- 2019/02/02 06:00 [pubmed]
PHST- 2019/04/23 06:00 [medline]
PHST- 2019/02/02 06:00 [entrez]
PHST- 2019/02/28 00:00 [pmc-release]
AID - S1016-8478(23)00383-7 [pii]
AID - molce-42-2-151 [pii]
AID - 10.14348/molcells.2018.0423 [doi]
PST - ppublish
SO  - Mol Cells. 2019 Feb 28;42(2):151-160. doi: 10.14348/molcells.2018.0423. Epub 2019 
      Jan 24.