PMID- 30705244
OWN - NLM
STAT- MEDLINE
DCOM- 20200219
LR  - 20210109
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Jan 30
TI  - Protocol for a multicentre randomised controlled parallel-group trial to compare 
      the effectiveness of remotely delivered cognitive-behavioural and graded exercise 
      interventions with usual care alone to lessen the impact of fatigue in 
      inflammatory rheumatic diseases (LIFT).
PG  - e026793
LID - 10.1136/bmjopen-2018-026793 [doi]
LID - e026793
AB  - INTRODUCTION: Fatigue remains pervasive, disabling and challenging to manage 
      across all inflammatory rheumatic diseases (IRDs). Non-pharmacological 
      interventions, specifically cognitive-behavioural approaches (CBAs) and graded 
      exercise programmes designed to support and increase exercise, are valuable 
      treatments which help patients with IRD to manage their fatigue. Yet, healthcare 
      systems have encountered substantial barriers to the implementation of these 
      therapeutic options. Lessening the Impact of Fatigue in Inflammatory Rheumatic 
      Diseases: a Randomised Trial (LIFT) is designed to give insights into the 
      effectiveness of a remotely delivered standardised intervention for a range of 
      patients with IRD. It will also enable the exploration of putative moderating 
      factors which may allow for the future triage of patients and to investigate the 
      precise mediators of treatment effect in IRD-related fatigue. METHODS AND 
      ANALYSIS: LIFT is a pragmatic, multicentre, three-arm randomised, controlled 
      trial, which will test whether adapted CBA and personalised exercise programme 
      interventions can individually reduce the impact and severity of fatigue. This 
      will be conducted with up to 375 eligible patients diagnosed with IRD and 
      interventions will be delivered by rheumatology healthcare professionals, using 
      the telephone or internet-based audio/video calls. ETHICS APPROVAL AND 
      DISSEMINATION: Ethical approval has been granted by Wales REC 7 (17/WA/0065). 
      Results of this study will be disseminated through presentation at scientific 
      conferences and in scientific journal. A lay summary of the results will be sent 
      to participants. TRIAL REGISTRATION NUMBER: NCT03248518; Pre-results.
CI  - (c) Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published 
      by BMJ.
FAU - Martin, Kathryn R
AU  - Martin KR
AD  - Epidemiology Group, University of Aberdeen, Aberdeen, UK.
AD  - Aberdeen Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, 
      Aberdeen, UK.
FAU - Bachmair, Eva-Maria
AU  - Bachmair EM
AD  - Epidemiology Group, University of Aberdeen, Aberdeen, UK.
AD  - Aberdeen Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, 
      Aberdeen, UK.
FAU - Aucott, Lorna
AU  - Aucott L
AD  - Centre of Healthcare and Randomised Trials (CHaRT), Health Service Research Unit, 
      University of Aberdeen, Aberdeen, UK.
FAU - Dures, Emma
AU  - Dures E
AD  - Department of Nursing and Midwifery, University of the West of England, Academic 
      Rheumatology Unit, Bristol Royal Infirmary, Bristol, UK.
FAU - Emsley, Richard
AU  - Emsley R
AD  - Department of Biostatistics and Health Informatics, Institute of Psychiatry, 
      Psychology and Neuroscience, King's College London, London, UK.
FAU - Gray, Stuart R
AU  - Gray SR
AD  - Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular 
      Research Centre, University of Glasgow, Glasgow, UK.
FAU - Hewlett, Sarah
AU  - Hewlett S
AUID- ORCID: 0000-0001-7851-2039
AD  - Department of Nursing and Midwifery, University of the West of England, Academic 
      Rheumatology Unit, Bristol Royal Infirmary, Bristol, UK.
FAU - Kumar, Vinod
AU  - Kumar V
AD  - Department of Rheumatology, Ninewells Hospital, NHS Tayside, Dundee, UK.
FAU - Lovell, Karina
AU  - Lovell K
AD  - School of Health Sciences, University of Manchester, Manchester, UK.
FAU - Macfarlane, Gary J
AU  - Macfarlane GJ
AD  - Epidemiology Group, University of Aberdeen, Aberdeen, UK.
AD  - Aberdeen Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, 
      Aberdeen, UK.
FAU - MacLennan, Graeme
AU  - MacLennan G
AD  - Centre of Healthcare and Randomised Trials (CHaRT), Health Service Research Unit, 
      University of Aberdeen, Aberdeen, UK.
FAU - McNamee, Paul
AU  - McNamee P
AD  - Health Economics Research Unit, University of Aberdeen, Aberdeen, UK.
FAU - Norrie, John
AU  - Norrie J
AD  - Edinburgh Clinical Trials Unit, University of Edinburgh, Western General 
      Hospital, Edinburgh, UK.
FAU - Paul, Lorna
AU  - Paul L
AD  - School of Health and Life Science, Glasgow Caledonian University, Glasgow, UK.
FAU - Ralston, Stuart
AU  - Ralston S
AD  - Rheumatology and Bone Disease, University of Edinburgh, Western General Hospital, 
      Edinburgh, UK.
FAU - Siebert, Stefan
AU  - Siebert S
AD  - Institute of Infection, Immunity and Inflammation, University of Glasgow, 
      Glasgow, UK.
FAU - Wearden, Alison
AU  - Wearden A
AD  - School of Health Sciences, University of Manchester, Manchester, UK.
FAU - White, Peter D
AU  - White PD
AD  - Department of Psychological Medicine, Queen Mary University of London, 
      Bartholomew's Hospital, London, UK.
FAU - Basu, Neil
AU  - Basu N
AD  - Institute of Infection, Immunity and Inflammation, University of Glasgow, 
      Glasgow, UK.
LA  - eng
SI  - ClinicalTrials.gov/NCT03248518
GR  - HERU1/CSO_/Chief Scientist Office/United Kingdom
GR  - HSRU1/CSO_/Chief Scientist Office/United Kingdom
GR  - 21175/VAC_/Versus Arthritis/United Kingdom
PT  - Clinical Trial Protocol
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190130
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Cognitive Behavioral Therapy/*methods
MH  - Cost-Benefit Analysis
MH  - Exercise Therapy/*methods
MH  - Fatigue/*therapy
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - Quality of Life
MH  - Randomized Controlled Trials as Topic
MH  - Rheumatic Fever/physiopathology/*therapy
MH  - Severity of Illness Index
PMC - PMC6359876
OTO - NOTNLM
OT  - cognitive behavioural
OT  - exercise
OT  - fatigue
OT  - inflammatory rheumatic disease
OT  - lift
OT  - randomised controlled trial
COIS- Competing interests: None declared.
EDAT- 2019/02/02 06:00
MHDA- 2020/02/20 06:00
PMCR- 2019/01/30
CRDT- 2019/02/02 06:00
PHST- 2019/02/02 06:00 [entrez]
PHST- 2019/02/02 06:00 [pubmed]
PHST- 2020/02/20 06:00 [medline]
PHST- 2019/01/30 00:00 [pmc-release]
AID - bmjopen-2018-026793 [pii]
AID - 10.1136/bmjopen-2018-026793 [doi]
PST - epublish
SO  - BMJ Open. 2019 Jan 30;9(1):e026793. doi: 10.1136/bmjopen-2018-026793.