PMID- 30705773
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2152-5250 (Print)
IS  - 2152-5250 (Electronic)
IS  - 2152-5250 (Linking)
VI  - 10
IP  - 1
DP  - 2019 Feb
TI  - Snapshot: Implications for mTOR in Aging-related Ischemia/Reperfusion Injury.
PG  - 116-133
LID - 10.14336/AD.2018.0501 [doi]
AB  - Aging may aggravate the damage and dysfunction of different components of 
      multiorgan and thus increasing multiorgan ischemia/reperfusion (IR) injury. IR 
      injury occurs in many organs and tissues, which is a major cause of morbidity and 
      mortality worldwide. The kinase mammalian target of rapamycin (mTOR), an atypical 
      serine/threonine protein kinase, involves in the pathophysiological process of IR 
      injury. In this review, we first briefly introduce the molecular features of 
      mTOR, the association between mTOR and aging, and especially its role on 
      autophagy. Special focus is placed on the roles of mTOR during ischemic and IR 
      injury. We then clarify the association between mTOR and conditioning phenomena. 
      Following this background, we expand our discussion to potential future 
      directions of research in this area. Collectively, information reviewed herein 
      will serve as a comprehensive reference for the actions of mTOR in IR injury and 
      may be significant for the design of future research and increase the potential 
      of mTOR as a therapeutic target.
FAU - Liu, Dong
AU  - Liu D
AD  - 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, 100037, China.
FAU - Xu, Liqun
AU  - Xu L
AD  - 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, 100037, China.
AD  - 2Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical 
      University, 1 Xinsi Road, Xi'an 710038, China.
AD  - 3Cadet group 3, School of Basic Medical Sciences, The Fourth Military Medical 
      University, Xi'an 710032, China.
AD  - 4Laboratory Animal Center, The Fourth Military Medical University, Xi'an 710032, 
      China.
FAU - Zhang, Xiaoyan
AU  - Zhang X
AD  - 2Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical 
      University, 1 Xinsi Road, Xi'an 710038, China.
AD  - 3Cadet group 3, School of Basic Medical Sciences, The Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Shi, Changhong
AU  - Shi C
AD  - 4Laboratory Animal Center, The Fourth Military Medical University, Xi'an 710032, 
      China.
FAU - Qiao, Shubin
AU  - Qiao S
AD  - 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, 100037, China.
FAU - Ma, Zhiqiang
AU  - Ma Z
AD  - 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, 100037, China.
AD  - 2Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical 
      University, 1 Xinsi Road, Xi'an 710038, China.
FAU - Yuan, Jiansong
AU  - Yuan J
AD  - 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing, 100037, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190201
PL  - United States
TA  - Aging Dis
JT  - Aging and disease
JID - 101540533
PMC - PMC6345330
OTO - NOTNLM
OT  - Aging
OT  - Autophagy
OT  - Ischemia/reperfusion injury
OT  - mTOR
COIS- Conflict of interests No conflict of interests.
EDAT- 2019/02/02 06:00
MHDA- 2019/02/02 06:01
PMCR- 2019/02/01
CRDT- 2019/02/02 06:00
PHST- 2017/12/23 00:00 [received]
PHST- 2018/05/01 00:00 [accepted]
PHST- 2019/02/02 06:00 [entrez]
PHST- 2019/02/02 06:00 [pubmed]
PHST- 2019/02/02 06:01 [medline]
PHST- 2019/02/01 00:00 [pmc-release]
AID - ad-10-1-116 [pii]
AID - 10.14336/AD.2018.0501 [doi]
PST - epublish
SO  - Aging Dis. 2019 Feb 1;10(1):116-133. doi: 10.14336/AD.2018.0501. eCollection 2019 
      Feb.