PMID- 30706445
OWN - NLM
STAT- MEDLINE
DCOM- 20200109
LR  - 20200401
IS  - 1096-8644 (Electronic)
IS  - 0002-9483 (Print)
IS  - 0002-9483 (Linking)
VI  - 168
IP  - 4
DP  - 2019 Apr
TI  - Age-related decline in urine concentration may not be universal: Comparative 
      study from the U.S. and two small-scale societies.
PG  - 705-716
LID - 10.1002/ajpa.23788 [doi]
AB  - OBJECTIVES: Evidence from industrialized populations suggests that urine 
      concentrating ability declines with age. However, lifestyle factors including 
      episodic protein intake and low hypertension may help explain differences between 
      populations. Whether this age-related decline occurs among small-scale 
      populations with active lifestyles and non-Western diets is unknown. We test the 
      universality of age-related urine concentration decline. MATERIALS AND METHODS: 
      We used urine specific gravity (Usg) and urine osmolality (Uosm) data from 15,055 
      U.S. nonpregnant adults without kidney failure aged 18-80 in 2007-2012 
      participating in the National Health and Nutrition Examination Survey (NHANES). 
      We tested the relationship of age on urine concentration biomarkers with multiple 
      linear regressions using survey commands. We compared results to longitudinal 
      data on Usg from 116 Tsimane' forager-horticulturalists (266 observations) adults 
      aged 18-83 in 2013-2014 from Lowland Bolivia, and to 38 Hadza hunter-gatherers 
      (156 observations) aged 18-75 in 2010-2015 from Tanzania using random-effects 
      panel linear regressions. RESULTS: Among U.S. adults, age was significantly 
      negatively associated with Usg (Adjusted beta [B] = -0.0009 g/mL/10 years; 
      SE = 0.0001; p < 0.001) and Uosm (B = -28.1 mOsm/kg/10 yr; SE = 2.4; p < 0.001). 
      In contrast, among Tsimane' (B = 0.0003 g/mL/10 yr; SE = 0.0002; p = 0.16) and 
      Hadza (B = -0.0004 g/mL/10 yr; SE = 0.0004; p = 0.29) age was not associated with 
      Usg. Older Tsimane' and Hadza exhibited similar within-individual variability in 
      Usg equivalent to younger adults. DISCUSSION: While U.S. adults exhibited 
      age-related declines in urine concentration, Tsimane' and Hadza adults did not 
      exhibit the same statistical decline in Usg. Mismatches between evolved 
      physiology and modern environments in lifestyle may affect kidney physiology and 
      disease risk.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Rosinger, Asher Y
AU  - Rosinger AY
AUID- ORCID: 0000-0001-9587-1447
AD  - Department of Biobehavioral Health, Pennsylvania State University, State College, 
      Pennsylvania.
AD  - Department of Anthropology, Pennsylvania State University, State College, 
      Pennsylvania.
FAU - Pontzer, Herman
AU  - Pontzer H
AD  - Department of Evolutionary Anthropology, Duke University, Durham, North Carolina.
FAU - Raichlen, David A
AU  - Raichlen DA
AD  - School of Anthropology, University of Arizona, Tucson, Arizona.
FAU - Wood, Brian M
AU  - Wood BM
AD  - Department of Anthropology, University of California Los Angeles, Los Angeles, 
      California.
AD  - Department of Human Behavior, Ecology and Culture, Max Planck Institute for 
      Evolutionary Anthropology, Leipzig, Germany.
FAU - Tanner, Susan N
AU  - Tanner SN
AD  - Department of Anthropology, University of Georgia, Athens, Georgia.
FAU - Sands, Jeff M
AU  - Sands JM
AD  - Department of Medicine, Renal Division, Emory University, Atlanta, Georgia.
LA  - eng
GR  - NSF-BCS 1440841/National Science Foundation/International
GR  - NSF-BCS-0850815/National Science Foundation/International
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - R01 DK041707/DK/NIDDK NIH HHS/United States
GR  - #1341161/National Science Foundation/International
GR  - #8718/Wenner-Gren Foundation/International
GR  - NSF-BCS 1440671/National Science Foundation/International
GR  - 8718/Wenner-Gren Foundation/International
GR  - NSF-BCS 1440867/National Science Foundation/International
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20190131
PL  - United States
TA  - Am J Phys Anthropol
JT  - American journal of physical anthropology
JID - 0400654
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Biomarkers/urine
MH  - Bolivia/epidemiology
MH  - Female
MH  - Humans
MH  - Kidney/*physiology
MH  - *Kidney Diseases/epidemiology/physiopathology/urine
MH  - Life Style
MH  - Male
MH  - Middle Aged
MH  - Tanzania/epidemiology
MH  - United States/epidemiology
MH  - Urinalysis/*statistics & numerical data
MH  - Young Adult
PMC - PMC6482828
MID - NIHMS1024059
OTO - NOTNLM
OT  - aging
OT  - kidney physiology
OT  - lifestyle mismatch
OT  - urine concentration
EDAT- 2019/02/02 06:00
MHDA- 2020/01/10 06:00
PMCR- 2020/04/01
CRDT- 2019/02/02 06:00
PHST- 2018/10/04 00:00 [received]
PHST- 2019/01/09 00:00 [revised]
PHST- 2019/01/14 00:00 [accepted]
PHST- 2019/02/02 06:00 [pubmed]
PHST- 2020/01/10 06:00 [medline]
PHST- 2019/02/02 06:00 [entrez]
PHST- 2020/04/01 00:00 [pmc-release]
AID - 10.1002/ajpa.23788 [doi]
PST - ppublish
SO  - Am J Phys Anthropol. 2019 Apr;168(4):705-716. doi: 10.1002/ajpa.23788. Epub 2019 
      Jan 31.