PMID- 30706530 OWN - NLM STAT- MEDLINE DCOM- 20190325 LR - 20190325 IS - 1532-950X (Electronic) IS - 0161-3499 (Linking) VI - 48 IP - 2 DP - 2019 Feb TI - Effect of prophylactic treatment with levetiracetam on the incidence of postattenuation seizures in dogs undergoing surgical management of single congenital extrahepatic portosystemic shunts. PG - 164-172 LID - 10.1111/vsu.13141 [doi] AB - OBJECTIVE: To report the incidence of postattenuation seizures (PAS) in dogs that underwent single congenital extrahepatic portosystemic shunt (cEHPSS) attenuation and to compare incidence of PAS in dogs that either did or did not receive prophylactic treatment with levetiracetam (LEV). STUDY DESIGN: Multi-institutional retrospective study. POPULATION: Nine hundred forty dogs. METHODS: Medical records were reviewed to identify dogs that underwent surgical attenuation of a single cEHPSS from January 2005 through July 2017 and developed PAS within 7 days postoperatively. Dogs were divided into 3 groups: no LEV (LEV-); LEV at >/=15 mg/kg every 8 hours for >/=24 hours preoperatively or a 60 mg/kg intravenous loading dose perioperatively, followed by >/=15 mg/kg every 8 hours postoperatively (LEV1); and LEV at <15 mg/kg every 8 hours, for <24 hours preoperatively, or continued at <15 mg/kg every 8 hours postoperatively (LEV2). RESULTS: Seventy-five (8.0%) dogs developed PAS. Incidence of PAS was 35 of 523 (6.7%), 21 of 188 (11.2%), and 19 of 228 (8.3%) in groups LEV-, LEV1, and LEV2, respectively. This difference was not statistically significant (P = .14). No differences between groups of dogs that seized with respect to investigated variables were identified. CONCLUSION: The overall incidence of PAS was low (8%). Prophylactic treatment with LEV according to the protocols that were investigated in our study was not associated with a reduced incidence of PAS. CLINICAL SIGNIFICANCE: Prophylactic treatment with LEV does not afford protection against development of PAS. Surgically treated dogs should continue to be monitored closely during the first 7 days postoperatively for seizures. CI - (c) 2018 The American College of Veterinary Surgeons. FAU - Mullins, Ronan A AU - Mullins RA AUID- ORCID: 0000-0003-1159-2382 AD - Section of Veterinary Clinical Sciences, University College Dublin, Belfield, Dublin, Ireland. FAU - Sanchez Villamil, Carlos AU - Sanchez Villamil C AD - Section of Veterinary Clinical Sciences, University College Dublin, Belfield, Dublin, Ireland. FAU - de Rooster, Hilde AU - de Rooster H AD - Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium. FAU - Kummeling, Anne AU - Kummeling A AD - Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. FAU - White, Robert N AU - White RN AD - Willows Veterinary Centre and Referral Service, Shirley, Solihull, West Midlands, United Kingdom. AD - Abbey House Veterinary Hospital, Morley, Leeds, United Kingdom. AD - School of Veterinary Medicine & Science, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom. FAU - Thieman Mankin, Kelley M AU - Thieman Mankin KM AD - Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas. FAU - Tivers, Michael S AU - Tivers MS AUID- ORCID: 0000-0001-7047-9334 AD - Bristol Veterinary School, University of Bristol, Langford House, Langford, Bristol, United Kingdom. FAU - Yool, Donald A AU - Yool DA AD - The Royal (Dick) School of Veterinary Studies, Easter Bush Campus, Midlothian, Edinburgh, United Kingdom. FAU - Anderson, Davina M AU - Anderson DM AD - Anderson Moores Veterinary Specialists, Hursley, Winchester, United Kingdom. FAU - Pratschke, Kathryn M AU - Pratschke KM AD - North East Veterinary Referrals, Northumberland Business Park West, Cramlington, Northumberland, United Kingdom. AD - University of Glasgow School of Veterinary Medicine, Bearsden, Glasgow, United Kingdom. FAU - Gordo, Ines AU - Gordo I AD - Pride Veterinary Centre, Derby, Derbyshire, United Kingdom. FAU - Brissot, Herve AU - Brissot H AD - Pride Veterinary Centre, Derby, Derbyshire, United Kingdom. FAU - Singh, Ameet AU - Singh A AD - Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. FAU - Olive, Melanie AU - Olive M AD - Centre Hospitalier Veterinaire Atlantia, Nantes, France. FAU - Billet, Jean Phillipe AU - Billet JP AD - Centre Hospitalier Veterinaire Atlantia, Nantes, France. FAU - Selmic, Laura E AU - Selmic LE AD - Department of Veterinary Clinical Sciences, The Ohio State University, 601 Vernon L Tharp St, Columbus, OH 43210. FAU - Kirby, Barbara M AU - Kirby BM AD - Section of Veterinary Clinical Sciences, University College Dublin, Belfield, Dublin, Ireland. LA - eng PT - Journal Article DEP - 20181227 PL - United States TA - Vet Surg JT - Veterinary surgery : VS JID - 8113214 RN - 0 (Anticonvulsants) RN - 44YRR34555 (Levetiracetam) SB - IM MH - Administration, Intravenous MH - Animals MH - Anticonvulsants/therapeutic use MH - Dog Diseases/*congenital/prevention & control/surgery MH - Dogs MH - Female MH - Incidence MH - Levetiracetam/*therapeutic use MH - Male MH - Portal System/*abnormalities MH - Postoperative Complications/prevention & control/*veterinary MH - Postoperative Period MH - Retrospective Studies MH - Seizures/prevention & control/*veterinary MH - Vascular Malformations/surgery/*veterinary EDAT- 2019/02/02 06:00 MHDA- 2019/03/26 06:00 CRDT- 2019/02/02 06:00 PHST- 2018/05/26 00:00 [received] PHST- 2018/10/12 00:00 [revised] PHST- 2018/11/06 00:00 [accepted] PHST- 2019/02/02 06:00 [entrez] PHST- 2019/02/02 06:00 [pubmed] PHST- 2019/03/26 06:00 [medline] AID - 10.1111/vsu.13141 [doi] PST - ppublish SO - Vet Surg. 2019 Feb;48(2):164-172. doi: 10.1111/vsu.13141. Epub 2018 Dec 27.