PMID- 30707112
OWN - NLM
STAT- MEDLINE
DCOM- 20210423
LR  - 20210423
IS  - 1536-3724 (Electronic)
IS  - 1050-642X (Linking)
VI  - 30
IP  - 5
DP  - 2020 Sep
TI  - Donor-Specific Human Leukocyte Antigen Antibody Formation After Distal Tibia 
      Allograft and Subsequent Graft Resorption.
PG  - e156-e158
LID - 10.1097/JSM.0000000000000715 [doi]
AB  - The association between donor-specific human leukocyte antigen (HLA) antibody 
      formation and small bone allograft resorption has not been studied. We present 
      the case of a patient treated for glenoid bone loss using a distal tibial 
      allograft with Bankart repair who formed donor-specific HLA antibodies against 
      the allograft and had subsequent graft resorption. X-ray and computed tomography 
      (CT) scans were performed before and after surgery at standard checkpoints. 
      Patient blood and serum samples were collected before and after surgery for HLA 
      typing and HLA antibody testing. Human leukocyte antigen antibodies against the 
      donor-specific HLA-A2 antigens were identified 6 weeks after surgery and were 
      still detected at 5 months after surgery. At 6 months after surgery, a CT 
      arthrogram revealed significant graft resorption. This case shows a temporal 
      correlation between HLA antibody formation and clinical findings, potentially 
      suggesting an association between HLA antibody formation and graft resorption. 
      Further study is required to confirm this.
FAU - Liwski, Christopher R
AU  - Liwski CR
AD  - Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova 
      Scotia, Canada; and the Departments of.
FAU - Dillman, Daryl
AU  - Dillman D
AD  - Surgery, Division of Orthopedics; and.
FAU - Liwski, Robert S
AU  - Liwski RS
AD  - Pathology, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, 
      Canada.
FAU - Wong, Ivan H
AU  - Wong IH
AD  - Surgery, Division of Orthopedics; and.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin J Sport Med
JT  - Clinical journal of sport medicine : official journal of the Canadian Academy of 
      Sport Medicine
JID - 9103300
RN  - 0 (Antibodies)
RN  - 0 (HLA-A2 Antigen)
SB  - IM
MH  - Adolescent
MH  - Allografts/immunology
MH  - Antibodies/*blood/immunology
MH  - Bone Resorption/diagnostic imaging/*immunology
MH  - HLA-A2 Antigen/*immunology
MH  - Host vs Graft Reaction/*immunology
MH  - Humans
MH  - Humeral Head/diagnostic imaging
MH  - Male
MH  - Shoulder Dislocation/diagnostic imaging
MH  - Tibia/*transplantation
MH  - Time Factors
MH  - Transplantation, Homologous
EDAT- 2019/02/02 06:00
MHDA- 2021/04/24 06:00
CRDT- 2019/02/02 06:00
PHST- 2019/02/02 06:00 [pubmed]
PHST- 2021/04/24 06:00 [medline]
PHST- 2019/02/02 06:00 [entrez]
AID - 00042752-202009000-00024 [pii]
AID - 10.1097/JSM.0000000000000715 [doi]
PST - ppublish
SO  - Clin J Sport Med. 2020 Sep;30(5):e156-e158. doi: 10.1097/JSM.0000000000000715.