PMID- 30707314
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2110-5820 (Print)
IS  - 2110-5820 (Electronic)
IS  - 2110-5820 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Feb 1
TI  - Impact of levosimendan on weaning from peripheral venoarterial extracorporeal 
      membrane oxygenation in intensive care unit.
PG  - 24
LID - 10.1186/s13613-019-0503-1 [doi]
LID - 24
AB  - BACKGROUND: Few data are available on the impact of levosimendan in refractory 
      cardiogenic shock patients undergoing peripheral venoarterial extracorporeal 
      membrane oxygenation (VA-ECMO). The aim of this study was to evaluate the impact 
      of levosimendan on VA-ECMO weaning in patients hospitalized in intensive care 
      unit (ICU). METHODS: This retrospective cohort study was conducted in a French 
      university hospital from 2010 to 2017. All patients hospitalized in ICU 
      undergoing VA-ECMO were consecutively evaluated. RESULTS: A total of 150 patients 
      undergoing VA-ECMO were eligible for the study. Thirty-eight propensity-matched 
      patients were evaluated in the levosimendan group and 65 in the non-levosimendan 
      group. In patients treated with levosimendan, left ventricular ejection fraction 
      had increased from 21.5 +/- 9.1% to 30.7 +/- 13.5% (P < 0.0001) and aortic 
      velocity-time integral from 8.9 +/- 4 cm to 12.5 +/- 3.8 cm (P = 0.002) 24 h after 
      drug infusion. After propensity score matching, levosimendan was the only factor 
      associated with a significant reduction in VA-ECMO weaning failure rates (hazard 
      ratio = 0.16; 95% confidence interval 0.04-0.7; P = 0.01). Kaplan-Meier survival 
      curves showed that survival rates at 30 days were 78.4% for the levosimendan 
      group and 49.5% for the non-levosimendan group (P = 0.02). After propensity score 
      matching analysis, the difference in 30-day mortality between the two groups was 
      not significant (hazard ratio = 0.55; 95% confidence interval 0.27-1.10; 
      P = 0.09). CONCLUSIONS: Our results suggest that levosimendan was associated with 
      a beneficial effect on VA-ECMO weaning in ICU patients.
FAU - Vally, Shamir
AU  - Vally S
AD  - Reanimation polyvalente, Centre Hospitalier Universitaire Felix Guyon, 97405, 
      Saint-Denis, Allee des Topazes, France.
FAU - Ferdynus, Cyril
AU  - Ferdynus C
AD  - Unite de Soutien Methodologique, CHU de La Reunion, Saint-Denis, France.
AD  - INSERM, CIC 1410, Saint-Pierre, France.
FAU - Persichini, Romain
AU  - Persichini R
AD  - Reanimation polyvalente, Centre Hospitalier Universitaire Felix Guyon, 97405, 
      Saint-Denis, Allee des Topazes, France.
FAU - Bouchet, Bruno
AU  - Bouchet B
AD  - Reanimation polyvalente, Centre Hospitalier Universitaire Felix Guyon, 97405, 
      Saint-Denis, Allee des Topazes, France.
FAU - Braunberger, Eric
AU  - Braunberger E
AD  - Chirurgie cardiaque, Centre Hospitalier Universitaire Felix Guyon, 97405, 
      Saint-Denis, Allee des Topazes, France.
FAU - Lo Pinto, Hugo
AU  - Lo Pinto H
AD  - Reanimation polyvalente, Centre Hospitalier Universitaire Felix Guyon, 97405, 
      Saint-Denis, Allee des Topazes, France.
FAU - Martinet, Olivier
AU  - Martinet O
AD  - Reanimation polyvalente, Centre Hospitalier Universitaire Felix Guyon, 97405, 
      Saint-Denis, Allee des Topazes, France.
FAU - Vandroux, David
AU  - Vandroux D
AD  - Reanimation polyvalente, Centre Hospitalier Universitaire Felix Guyon, 97405, 
      Saint-Denis, Allee des Topazes, France.
FAU - Aujoulat, Thomas
AU  - Aujoulat T
AD  - Reanimation polyvalente, Centre Hospitalier Universitaire Felix Guyon, 97405, 
      Saint-Denis, Allee des Topazes, France.
FAU - Allyn, Jerome
AU  - Allyn J
AD  - Reanimation polyvalente, Centre Hospitalier Universitaire Felix Guyon, 97405, 
      Saint-Denis, Allee des Topazes, France.
FAU - Allou, Nicolas
AU  - Allou N
AD  - Reanimation polyvalente, Centre Hospitalier Universitaire Felix Guyon, 97405, 
      Saint-Denis, Allee des Topazes, France. nicolas.allou@chu-reunion.fr.
AD  - Reanimation polyvalente, Hopital Felix Guyon, Bellepierre, 97405, Saint-Denis, 
      France. nicolas.allou@chu-reunion.fr.
LA  - eng
PT  - Journal Article
DEP - 20190201
PL  - Germany
TA  - Ann Intensive Care
JT  - Annals of intensive care
JID - 101562873
PMC - PMC6358626
OTO - NOTNLM
OT  - Extracorporeal membrane oxygenation
OT  - Levosimendan
OT  - Mortality
OT  - Weaning
EDAT- 2019/02/02 06:00
MHDA- 2019/02/02 06:01
PMCR- 2019/02/01
CRDT- 2019/02/02 06:00
PHST- 2018/11/14 00:00 [received]
PHST- 2019/01/29 00:00 [accepted]
PHST- 2019/02/02 06:00 [entrez]
PHST- 2019/02/02 06:00 [pubmed]
PHST- 2019/02/02 06:01 [medline]
PHST- 2019/02/01 00:00 [pmc-release]
AID - 10.1186/s13613-019-0503-1 [pii]
AID - 503 [pii]
AID - 10.1186/s13613-019-0503-1 [doi]
PST - epublish
SO  - Ann Intensive Care. 2019 Feb 1;9(1):24. doi: 10.1186/s13613-019-0503-1.