PMID- 30711436
OWN - NLM
STAT- MEDLINE
DCOM- 20190506
LR  - 20190506
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 149
DP  - 2019 Mar
TI  - Serum lactate levels are associated with serum alanine aminotransferase and total 
      bilirubin levels in patients with type 2 diabetes mellitus: A cross-sectional 
      study.
PG  - 1-8
LID - S0168-8227(18)31655-3 [pii]
LID - 10.1016/j.diabres.2019.01.028 [doi]
AB  - AIMS: It was recently reported that lactate acts as a metabolic mediator and 
      rises in the diabetic state, but the physiological effects are as yet poorly 
      understood. The objective of the current study was to evaluate the significance 
      of serum lactate elevation in type 2 diabetes mellitus (T2DM) patients. METHODS: 
      Fasting serum lactate levels, hematological and inflammatory serum markers and 
      anthropometric parameters, obtained employing bioelectric impedance analysis, 
      were measured in 103 patients with T2DM. RESULTS: Statistically significant 
      correlations of serum lactate levels with C-reactive peptide, insulin, aspartate 
      aminotransferase, alanine aminotransferase (ALT), serum lipids, total bilirubin, 
      adiponectin, homeostasis model assessment-insulin resistance, body weight, body 
      mass index and body fat (weight or percentage of subcutaneous fat, visceral fat 
      or total body fat), but neither fasting plasma glucose nor HbA1c, were detected. 
      Stepwise regression analysis showed ALT to be independently positively associated 
      with total bilirubin, while being negatively associated with serum lactate 
      levels. Furthermore, serum lactate levels were significantly higher in patients 
      with ALT-predominant liver dysfunction. CONCLUSION: We found fasting serum 
      lactate elevation in T2DM patients to be associated with the serum levels of ALT 
      and total bilirubin independently of blood glucose control. TRIAL REGISTRATION: 
      UMIN clinical trials registry (UMIN000029178).
CI  - Copyright (c) 2019 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Ishitobi, Minori
AU  - Ishitobi M
AD  - Third Department of Internal Medicine, Division of Diabetes, Endocrinology and 
      Metabolism, Kyorin University School of Medicine, Tokyo 181-8611, Japan.
FAU - Hosaka, Toshio
AU  - Hosaka T
AD  - Graduate Program in Food and Nutritional Science, Graduate School of Integrated 
      Pharmaceutical and Nutritional Science, The University of Shizuoka, Shizuoka 
      422-8526, Japan. Electronic address: toshio.hosaka@u-shizuoka-ken.ac.jp.
FAU - Morita, Naru
AU  - Morita N
AD  - Third Department of Internal Medicine, Division of Diabetes, Endocrinology and 
      Metabolism, Kyorin University School of Medicine, Tokyo 181-8611, Japan.
FAU - Kondo, Ken
AU  - Kondo K
AD  - Third Department of Internal Medicine, Division of Diabetes, Endocrinology and 
      Metabolism, Kyorin University School of Medicine, Tokyo 181-8611, Japan.
FAU - Murashima, Toshitaka
AU  - Murashima T
AD  - Third Department of Internal Medicine, Division of Diabetes, Endocrinology and 
      Metabolism, Kyorin University School of Medicine, Tokyo 181-8611, Japan.
FAU - Kitahara, Atsuko
AU  - Kitahara A
AD  - Third Department of Internal Medicine, Division of Diabetes, Endocrinology and 
      Metabolism, Kyorin University School of Medicine, Tokyo 181-8611, Japan.
FAU - Takahashi, Kazuto
AU  - Takahashi K
AD  - Third Department of Internal Medicine, Division of Diabetes, Endocrinology and 
      Metabolism, Kyorin University School of Medicine, Tokyo 181-8611, Japan.
FAU - Sumitani, Yoshikazu
AU  - Sumitani Y
AD  - Third Department of Internal Medicine, Division of Diabetes, Endocrinology and 
      Metabolism, Kyorin University School of Medicine, Tokyo 181-8611, Japan.
FAU - Tanaka, Toshiaki
AU  - Tanaka T
AD  - Third Department of Internal Medicine, Division of Diabetes, Endocrinology and 
      Metabolism, Kyorin University School of Medicine, Tokyo 181-8611, Japan.
FAU - Yokoyama, Toshihiko
AU  - Yokoyama T
AD  - Nihon Wellness Chikuhoku High School, Nagano 399-7501, Japan.
FAU - Kondo, Takuma
AU  - Kondo T
AD  - Third Department of Internal Medicine, Division of Diabetes, Endocrinology and 
      Metabolism, Kyorin University School of Medicine, Tokyo 181-8611, Japan.
FAU - Ishida, Hitoshi
AU  - Ishida H
AD  - Third Department of Internal Medicine, Division of Diabetes, Endocrinology and 
      Metabolism, Kyorin University School of Medicine, Tokyo 181-8611, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190131
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Lactates)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Alanine Transaminase/*metabolism
MH  - Bilirubin/*metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Lactates/*metabolism
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Alanine aminotransferase
OT  - Lactate
OT  - Liver steatosis
OT  - Total bilirubin
OT  - Type 2 diabetes mellitus
EDAT- 2019/02/04 06:00
MHDA- 2019/05/07 06:00
CRDT- 2019/02/04 06:00
PHST- 2018/11/01 00:00 [received]
PHST- 2018/12/28 00:00 [revised]
PHST- 2019/01/24 00:00 [accepted]
PHST- 2019/02/04 06:00 [pubmed]
PHST- 2019/05/07 06:00 [medline]
PHST- 2019/02/04 06:00 [entrez]
AID - S0168-8227(18)31655-3 [pii]
AID - 10.1016/j.diabres.2019.01.028 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2019 Mar;149:1-8. doi: 10.1016/j.diabres.2019.01.028. 
      Epub 2019 Jan 31.